Clinical classification of bioengineered skin use and its correlation with healing of diabetic and venous ulcers

Dermatologic Surgery

Volumn 30, Issue 8, 2004, Pages 1095-1100

  Saap, Liliana J ^a   Donohue, Kevin ^a   Falanga, Vincent ^a,b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BIOENGINEERING; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DIABETIC FOOT; EPITHELIZATION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; TREATMENT OUTCOME; ULCER HEALING; WOUND CLOSURE; WOUND HEALING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DIABETIC FOOT; FEMALE; HUMANS; LEG ULCER; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; SEVERITY OF ILLNESS INDEX; SKIN, ARTIFICIAL; WOUND HEALING;

EID: 4344630919     PISSN: 10760512     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2004.30334.x     Document Type: Article

References (24)

1. Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch Dermatol 1998;134:293-300.
2. Falanga V, Sabolinski M. A bilayered living skin construct (Apligraf) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen 1999;7:201-7.
3. Bolivar-Flores YJ, Kuri-Harcuch W. Frozen allogeneic human epidermal cultured sheets for the cure of complicated leg ulcers. Dermatol Surg 1999;25:610-7.
4. Brern H, Balledux J, Sukkarieh T, Carson P, Falanga V. Healing of venous ulcers of long duration with a bilayered living skin substitute: results from a general surgery and a dermatology department. Dermatol Surg 2001;27:915-9.
5. Veves A, Falanga V, Armstrong DG, Sabolinski M; Apligraf Diabetic Foot Ulcer Study. Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. Diabetes Care 2001;24:290-5.
6. Gentzkow GD, Iwasaki SD, Hershorn KS, et al. Use of Dermagrat, a cultured human dermis, to treat diabetic foot ulcers. Diabetes Care 1996;19:350-4.
7. Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Healing of diabteic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing. Arch Surg 2000;135:627-34.
8. Hansen SL, Voigt DW, Wiebelhaus P, Paul CN. Using skin replacement products to treat burns and wounds. Adv Skin Wound Care 2001;14:37-44.
9. Stephens R, Wilson K, Silverstein P. A premature infant with skin injury successfully treated with bilayered cellular matrix. Ostomy Wound Manage 2002;48:34-8.
10. Horn WA. Case report: Graftskin heals an ulcer on an amputation stump. Dernatol Surg 2000;26:946-8.
11. de Imus G, Golomb C, Wilkel C, et al. Accelerated healing of pyoderma gangrenosum treated with bioengineered skin and concomitant immunosuppression. J Am Acad Dermatol 2001;44:61-6.
12. Falabella AF, Schachner LA, Valencia IC, Eaglstein WH. The use of tissue-engineered skin (Apligraf) to treat a newborn with epidermolysis bullosa. Arch Dermatol 1999;135:1219-22.
13. Harding KG, Morris HL, Patel GK. Healing chronic wounds. BMJ 2002;324:160-3.
14. Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen 2000;8:347-52.
15. Falanga V. A classification system for evaluating graft appearance and early clinical outcome of bioengineered skin in human wounds. J Invest Dermatol 2000;114:839.
16. Schonfeld WH, Villa KF, Fastenau JM, Mazonson PD, Falanga V. An economic assessment of Apligraf (Graftskin) for the treatment of hard-to-heal venous ulcers [comment]. Wound Repair Regen 2000;8:251-7.
17. Sibbald RG, Torrance GW, Walker V, Attard C, MacNeil P. Cost-effectiveness of Apligraf in the treatment of venous ulcers. Ostomy Wound Manage 2001;47:36-4.
18. Ennis WJ, Meneses P. Wound healing at the local level: the stunned wound. Ostomy Wound Manage 2000;46(Suppl 1A): 39s-48s.
19. Sabolinski ML, Alvarez O, Auletta M, Mulder G, Parenteau NL. Cultured skin as a "smart material" for healing wounds: experience in venous ulcers. Biomaterials 1996;17:311-20.
20. Falanga V, Isaacs C, Paquette D, et al. Wounding of bioengineered skin: cellular and molecular aspects after injury. J Invest Dermatol 2002;119:653-60.
21. Phillips TJ, Manzoor J, Rojas A, et al. The longevity of a bilayered skin substitute after application to venous ulcers. Arch Dermatol 2002;138:1079-81.
22. Badiavas EV, Paquette D, Carson P, Falanga V. Human chronic wounds treated with bioengineered skin: histologic evidence of host-graft interactions. J Am Acad Dermatol 2002;46:524-30.
23. Saap LJ, Falanga V. Debridement performance index and its correlation with complete closure of diabetic foot ulcers. Wound Repair Regen 2002;10:354-9.
24. Steed DL, Donohue D, Webster M, Lindsey L. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group. J Am Coll Surg 1996;183:61-4.