Hypoxia-inducible factor-1 alpha regulates the role of vascular endothelial growth factor on pulmonary arteries of rats with hypoxia-induced pulmonary hypertension

Chinese Medical Journal

Volumn 117, Issue 7, 2004, Pages 1023-1028

  Li, Qi Fang ^a   Dai, Ai Guo ^b  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b Hunan Province Geriatric Hospital   (China)

Author keywords

Hypertension; Hypoxia inducible factor 1; Vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; EXPOSURE; HEART INDEX; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG ARTERY PRESSURE; LUNG INFLATION; MALE; MEAN ARTERIAL PRESSURE; MORPHOMETRICS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; RAT STRAIN; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE;

ANIMALS; ANOXIA; BLOOD PRESSURE; CHRONIC DISEASE; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; PULMONARY ARTERY; RATS; RATS, WISTAR; RNA, MESSENGER; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 4344575742     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Helen CH, Astushi Y, Victoria A, et al. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia induced pulmonary hypotension. Am J Respir Cell Mol Biol 1998;18:768-776.
2. Forsythe JA, Jiang BH, Iyer NV et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-4613.
3. Dai AG, Zhang ZX, Niu RJ et al. Attenuation of nitric oxide synthase gene expression in rat lung induced by hypoxia. J Tongji Med Univ ( Chin ) 1996;16:148-151.
4. Xu P, Dai AG, Zhou HD. Expression of adrenomedullion and its receptor in lungs of rats with hypoxia-induced pulmonary hypertension. Chin J Tuberc Respir Dis (Chin) 2002;25: 465-469.
5. Deborah MS, Tobias B, Isebelle D, et al. HIF-1 is expressed in normoxic tissue and displays an organ-speciffic regulation under systemic hypoxia. FASEB J 2001;15:2445-2453.
6. Zhong X, Liang G, He I. The roles of vascular endothelial growth factor and endothelin-1 on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension. Chin J Intern Med (Chin) 2001;40:525-528.
7. Judith AN. Physiological and genomic consequences of intermittent hypoxia: physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol 2001;90: 1593-1599.
8. Wood SM, Gleadle J M, Pugh CW, et al. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: studies in ARNT-deficient cells. J Biol Chem 1996;271:15117-15123.
9. Shima DT, Kuroki M, Deutsch U, et al. The mouse gene for vascular endothelial growth factor: genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J Biol Chem 1996;271:3877-3883.
10. Yamazaki Y, Egawa K, Nose K, et al. HIF-1 dependent VEGF receptor gene assay by a stable transformant of CHO cells. Biol Pharm Bull 2003;26:417-420.
11. David P, Reid L. Hypoxic remodeling of the rat pulmonary arterial microcirculation assessed by microdissection. J Appl Physiol 1991;71:1886-1891.
12. Mecham RP, Whitehouse LA, Wrenn DS, et al. Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. Science 1987;237:423-426.