The need to decide if all estrogens are intrinsically similar

Environmental Health Perspectives

Volumn 112, Issue 11, 2004, Pages 1137-1142

  Moggs, Jonathan G ^a   Ashby, John ^a   Tinwell, Helen ^a   Lim, Fei Ling ^a   Moore, David J ^a   Kimber, Ian ^a   Orphanides, George ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Diethystilbestrol; Estrogen; Gene expression; Genistein; Microarray; Phytoestrogen; Toxicogenomics; Uterus

Indexed keywords

DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN DERIVATIVE; GENISTEIN; PHYTOESTROGEN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GRAVIMETRY; HEALTH HAZARD; HISTOLOGY; HORMONE DETERMINATION; IMMATURITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STANDARD; UNINDEXED SEQUENCE; UTERUS;

ANIMALIA;

EID: 4344567155     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.7028     Document Type: Article

References (39)

1. Aardema MJ, Albertini S, Arni P, Henderson LM, Kirsch-Volders M, Mackay JM, et al. 1998. Aneuploidy: a report of an ECETOC task force. Mutat Res 410:3-79.
2. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, et al. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595.
3. Almstrup K, Fernandez MF, Petersen JH, Olea N, Skakkebaek NE, Leffers H. 2002. Dual effects of phytoestrogens result in U-shaped dose-response curves. Environ Health Perspect 110:743-748.
4. Arora A, Nair MG, Strasburg GM. 1998. Antioxidant activities of isoflavones and their biological metabolites in a liposomal system. Arch Biochem Biophys 356:133-141.
5. Casanova M, You L, Gaido KW, Archibeque-Engle S, Janszen DB, Heck HA. 1999. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors α and β in vitro. Toxicol Sci 51:236-244.
6. Cassidy A, Bingham S, Setchell KDR. 1994. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 60:333-340.
7. Cassidy A, Faughnan M. 2000. Phyto-oestrogens through the life cycle. Proc Nutr Soc 59:489-496.
8. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment. 2003. Phytoestrogens and Health. London:Food Standards Agency. Available: http://www.foodstandards.gov.uk/multimedia/pdfs/phytoreport0503 [accessed 2 June 2004].
9. Dean NM, Kanemitsu M, Boynton AL. 1989. Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells. Biochem Biophys Res Commun 165:795-801.
10. Duarte J, Ocete MA, Perez-Vizcaino F, Zarzuelo A, Tamargo J. 1997. Effect of tyrosine kinase and tyrosine phosphatase inhibitors on aortic contraction and induction of nitric oxide synthase. Eur J Pharmacol 338:25-33.
11. Frasor J, Barnett DH, Danes JM, Hess R, Parlow AF, Katzenellenbogen BS. 2003. Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) α activity by ERβ in the uterus. Endocrinology 144:3159-3166.
12. Genbank. 2004. Bethesda, MD:National Center for Biotechnology Information, National Library of Medicine. Available: http://www.ncbi.nlm.nih.gov/Genbank/GenbankOverview.html [accessed 2 June 2004].
13. GEO. 2004. Gene Expression Omnibus Homepage. Bethesda, MD:National Center for Biotechnology Information, National Library of Medicine. Available: http://www.ncbi.nlm.nih.gov/geo/ [accessed 2 June 2004].
14. Hall JM, Couse JF, Korach KS. 2001. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869-36872.
15. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, et al. 1997. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99:505-512.
16. Hewitt SC, Deroo BJ, Hansen K, Collins J, Grissom S, Afshari CA, et al. 2003. Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol 17:2070-2083.
17. Holm S. 1979. A simple sequentially rejective Bonferroni test procedure. Scand J Stat 6:65-70.
18. Howdeshell KL, Hotchkiss AK, Thayer KA, Vandenbergh JG, vom Saal FS. 1999. Exposure to bisphenol A advances puberty. Nature 401:763-764.
19. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, et al. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263.
20. Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V, et al. 2003. NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res 31:82-86.
21. Lund TD, Munson DJ, Haldy ME, Setchell KD, Lephart ED, Handa RJ. 2004. Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback. Biol Reprod 70:1188-1195.
22. Messina MJ. 1999. Legumes and soybeans: overview of their nutritional profiles and health effects. Am J Clin Nutr 70:439S-450S.
23. Moggs JG, Orphanides G. 2001 Estrogen receptors: orchestrators of pleiotropic cellular responses. EMBO Rep 9:775-781.
24. Naciff JM, Jump ML, Torontali SM, Carr GJ, Tiesman JP, Overmann GJ, et al. 2002. Gene expression profile induced by 17α -ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat. Toxicol Sci 68:184-199.
25. Naciff JM, Overmann GJ, Torontali SM, Carr GJ, Tiesman JP, Richardson BD, et al. 2003. Gene expression profile induced by 17α-ethynyl estradiol in the prepubertal female reproductive system of the rat. Toxicol Sci 72:314-330.
26. Newbold RR, Banks EP, Bullock B, Jefferson WN. 2001. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61:4325-4328.
27. North K, Golding J. 2000. A maternal vegetarian diet in pregnancy is associated with hypospadias. Br J Urol Int 85:107-113.
28. Odum J, Lefevre PA, Tittensor S, Paton D, Routledge ED, Beresford NA, et al. The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul Toxicol Pharmacol 25:176-188.
29. Okura A, Arakawa H, Oka H, Yoshinari T, Monden Y. 1988. Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells. Biochem Biophys Res Commun 157:183-189.
30. Orphanides G, Moggs JG, Spurway T, Tinwell H, Ashby J, Kimber I. 2003. Use of gene expression profiling to understand the transcriptional programme associated with estrogen-induced uterine growth: implications for the use of surrogate molecular markers in toxicology [Abstract]. Toxicol Sci 72:12.
31. Owens JW, Ashby J. 2002. Critical review and evaluation of the uterotrophic bioassay for the identification of possible estrogen agonists and antagonists: in support of the validation of the OECD uterotrophic protocols for the laboratory rodent. Organisation for Economic Co-operation and Development. Crit Rev Toxicol 32:445-520.
32. Paulozzi LJ, Erickson JD, Jackson RJ. 1997. Hypospadias: trends in two US surveillance systems. Pediatrics 100:831-834.
33. Potier B, Rovira C. 1999. Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices. Brain Res 816:587-597.
34. Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. 2002. Problems for risk assessment of endocrine-active estrogenic compounds. Environ Health Perspect 110:925-929.
35. Setchell KDR, Zimmer-Nechemias L, Cai J, Heubi JE. 1997. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 350:23-27.
36. Tinwell H, Ashby J. 2004. Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens. Environ Health Perspect 112:575-582.
37. Watanabe H, Suzuki A, Kobayashi M, Lubahn DB, Handa H, Iguchi T. 2003. Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens. J Mol Endocrinol 3:487-497.
38. Weihua Z, Saji S, Mäkinen S, Cheng G, Jensen EV, Warner M, et al. 2000. Estrogen receptor (ER) β a modulator of ERα in the uterus. Proc Natl Acad Sci USA 97:5936-5941.
39. Williams GM, Iatropoulos M, Cheung R, Radi L, Wang CX. 1993. Diethylstilbestrol liver carcinogenicity and modification of DNA in rats. Cancer Lett 68:193-198.