Synthesis and biological evaluation of a series of A,B-ring modified 16,17-secoandrostane derivatives

Bioorganic Chemistry

Volumn 36, Issue 3, 2008, Pages 128-132

  Sakač, Marija ^a   Gaković, Andrea ^a   Stojanović, Srdjan ^a   Djurendić, Evgenija ^a   Kojić, Vesna ^b   Bogdanović, Gordana ^b   Gaši, Katarina Penov ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b ONCOLOGY INSTITUTE OF VOJVODINA   (Serbia)

Author keywords

16,17 Secosteroids; Androstane derivatives; Aromatase inhibitors; In vitro cytotoxicity

Indexed keywords

16,17 SECOANDROSTANE DERIVATIVE; 17 METHYL 16,17 SECOANDROSTA 1,4 DIEN 3,17 DIONE 16 NITRILE; 17 METHYL 16,17 SECOANDROSTA 1,4,6 TRIEN 3,17 DIONE 16 NITRILE; 17 METHYL 16,17 SECOANDROSTA 4,6 DIEN 3,17 DIONE 16 NITRILE; 4 HYDROXY 17 METHYL 16,17 SECOANDROST 4 EN 3,17 DIONE 16 NITRILE; 4A,5A EPOXY 17 METHYL 16,17 SECOANDROSTA 3,17 DIONE 16 NITRILE; 4B,5B EPOXY 17 METHYL 16,17 SECOANDROSTA 3,17 DIONE 16 NITRILE; ANDROSTANE DERIVATIVE; AROMATASE; AROMATASE INHIBITOR; EXEMESTANE; FORMESTANE;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; CELL STRAIN MRC 5; CELL STRAIN PC 3; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; RAT;

ANDROSTANES; ANTINEOPLASTIC AGENTS; AROMATASE; AROMATASE INHIBITORS; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; FEMALE; HUMANS; MALE; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43349097373     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2008.01.002     Document Type: Article

References (14)

1. Miller W.R. Minerva Endocrinol. 31 (2006) 27-46
2. Brodie A. J. Steroid Biochem. Mol. Biol. 37 (1990) 327-333
3. Bulun S.E., Zeitoun K., Takayama K., Noble L., Michael D., Simpson E., Johns A., Putman M., and Sasano H. Endocr. Relat. Cancer 6 (1999) 293-301
4. Miller W.R., and Jackson J. Expert Opin. Investig. Drugs 12 (2003) 337-352
5. Coombes R.C., Hughes S.W., and Dowsett M. Eur. J. Cancer 28A (1992) 1941-1945
6. Lonning P.E. Expert Opin. Investig. Drugs 9 (2000) 1897-1905
7. Jovanović-Šanta S., Petrović J., Andrić S., Kovačević R., Sakač M., Lazar D., and Stanković S. Bioorg. Chem. 31 (2003) 475-484
8. Sakač M., Miljković D., Penov Gaši K., Popsavin M., Klisurić O., Stanković S., Andrić S., and Kovačević R. Collect. Czech. Chem. Commun. 70 (2005) 63-71
9. Penov Gaši K., Stanković S., Csanadi J., D{combining short stroke overlay}urendić E., Sakač M., Medić-Mijačević Lj., Arcson O., Stojanović S., Andrić S., Molnar Gabor D., and Kovačević R. Steroids 66 (2001) 645-653
10. Penov Gaši K., Stojanović S., Sakač M., {Eth}urendić E., Jovanović-Šanta S., Stanković S., Andrić N., and Popsavin M. J. Serb. Chem. Soc. 68 (2003) 707-714
11. Plourde P.V., Dyroff M., and Dukes M. Breast Cancer Res. Treat. 30 (1994) 103-111
12. Bhatnagar A.S., Häusler A., Schieweck K., Lang M., and Bowman R. J. Steroid Biochem. Mol. Biol. 37 (1990) 1021-1027
13. Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren T.J., Bokesch H., Kenney S., and Boyd R.M. J. Natl. Cancer Inst. 82 (1990) 1107-1112
14. E. Djurendić, M. Sakač, M. Zaviš, A. Gaković, J. Čanadi, S. Andrić, O. Klisurić, V. Kojić, G. Bogdanović, K. Penov Gaši, in press.