Histamine receptor H4R-selective ligands influence the STAT6 Transcription Activation Domain (TAD) and the DNA-binding

Inflammation Research

Volumn 57, Issue SUPPL. 1, 2008, Pages

  Michel, I ^a   Borck, H ^a   McElligott, S ^a   Krieg, C ^a   Diel, F ^a  

^a UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 BENZIMIDAZOLYLCARBONYL) 4 METHYLPIPERAZINE; 1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; DNA; HISTAMINE; INTERLEUKIN 2; INTERLEUKIN 4; JNK 10191584; STAT6 PROTEIN; 1 ((5 CHLORO 1H INDOL 2 YL)CARBONYL) 4 METHYLPIPERAZINE; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; ANTIHISTAMINIC AGENT; BENZIMIDAZOLE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, HUMAN; INDOLE DERIVATIVE; LIGAND; PIPERAZINE DERIVATIVE; STAT6 PROTEIN, HUMAN;

ADULT; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; FEMALE; FRIEDMAN TEST; GEL MOBILITY SHIFT ASSAY; GENE INTERACTION; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKEMIA CELL LINE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DOMAIN; STUDENT T TEST; TRANSCRIPTION INITIATION; ARTICLE; GENETICS; METABOLISM; MONONUCLEAR CELL; PROTEIN TERTIARY STRUCTURE; TRANSACTIVATION;

ADULT; BENZIMIDAZOLES; DNA; FEMALE; HISTAMINE ANTAGONISTS; HUMANS; INDOLES; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; LIGANDS; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS);

EID: 43249129070     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-0623-1     Document Type: Conference Paper

References (5)

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2. Horr B, Borck H, Diel J, Wackes C, Nierich K, Thurmond RL et al. The role of histamine H4 receptor in signal transduction of atopic and non-atopic human lymphocytes ex vivo. Inflamm res 2006; 55 Suppl 1: S53-54.
3. Diel F, Horr B, Borck H, Savtchenko H, Mitsche T, Diel E. Pyrethroids and piperony-butoxide affect human T-lymphocytes in vitro. Tox Letters 1999; 107: 65-74.
4. Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung W, Hofstra CL, Jiang W et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther 2004; 309: 404-13.
5. Lim HD, Smits RA, Bakker RA, van Dam CME, de Esch DJE, Leurs R. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazolehistamine H4 receptor agonist. J Med Chem 2006; 49: 6650-1.