Increased expression of gluconeogenic enzymes in the liver of IUGR rats and subsequent insulin resistance

Chinese Journal of Contemporary Pediatrics

Volumn 10, Issue 2, 2008, Pages 216-220

  Liu, Xiao Mei ^a   Lu, Yan ^a   Pan, Li Li ^a   Li, Shu Qin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Gluconeogenesis; Insulin resistance; Intrauterine growth retardation; Rats

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN; LIVER ENZYME; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOPYRUVATE CARBOXYLASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAUTERINE GROWTH RETARDATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN MALNUTRITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WEIGHT GAIN; WESTERN BLOTTING;

ANIMALS; FEMALE; FETAL GROWTH RETARDATION; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; INSULIN RESISTANCE; LIVER; MALE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RATS; RATS, WISTAR; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 43249128649     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Hales CN, Barker DJ. The thrifty phenotype hypothesis [J]. Br Med Bull, 2001, 60:5-20.
2. Phillips DI, Barker DJ, Hales CN, Hirst S, Osmond C. Thinness at birth and insulin resistance in adult life [J]. Diabetologia, 1994, 37(2):150-154.
3. Song S, Andrikopoulos S, Filippis C, Thorburn AW, Khan D, Proietto J. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin[J]. Am J Physiol Endocrinol Metab, 2001, 281 (2):275-282.
4. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 [J]. Nature, 2001, 413 (6852): 131-138.
5. Desai M, Gayle D, Babu J, Ross M G. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition[J]. Am J Physiol Regul Integr Comp Physiol, 2005, 288 (2): 91-96.
6. Ibanez L, Ong K, Dunger DB, Francis de Zegher. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children[J]. J Clin Endocrinol Metab, 2006, 91(6): 2153-2158.
7. Bazaes RA, Alegria A, Pittaluga E, Avila A, Iniguez G, Mericq V. Determinants of insulin sensitivity and secretion in very-low-birth-weight children [J]. J Clin Endocrinol Metab, 2004, 89 (3): 1267-1272.
8. Ong K, Ahmed ML, Emmett PM, Michael A, David P, Dunger B. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study [J]. BMJ, 2000, 320 (7240):967-971.
9. Osmand C, Barker DJ. Fetal, infant and childhood growth are predicator of coronary heart disease, diabetes and hypertation in adult man and women [J]. Environ Health Perspect, 2000, 108 (Suppl 3):545-553.
10. Bjorntorp P, Rosmond R. Visceral obesity and diabetes [J]. Drugs, 1999, 58(S1): 13-18.
11. Vuguin P, Raab E, Liu B, Barzilai N, Simmons R. Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation[J]. Diabetes, 2004, 53 (10): 2617-2622.
12. Chen L, Nyomba BL. Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure[J]. J Appl Physiol, 2004, 96(1):167-172.
13. Daitoku H, Yamagata K, Matsuzaki H. Regulation of PGC-1 promoter activity by proteinkinase B and the forkhead transcription factor FKHR[J]. Diabetes, 2003, 52(3):642-649.
14. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, et al. Suppression of beta cell energy metabolism and insulin release by PGC-1 alpha[J]. Dev Cell, 2003, 5(1):73-83.
15. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin regulated hepatic gluconeogenesis through FOXO1 -PGC-1α interaction[J]. Nature, 2003, 423 (6939): 550-555.
16. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, et al. Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis[J]. Proc Natl Acad Sci USA, 2003, 100 (7): 4012-4017.
17. Chinese source.