Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme and lactoferrin in elderly patients with dry mouth - A pilot study

Gerodontology

Volumn 25, Issue 1, 2008, Pages 3-9

  Gil Montoya, Jose Antonio ^a   Guardia López, Inmaculada ^a   González Moles, Miguel Angel ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Antimicrobial proteins; Elderly; Xerostomia

Indexed keywords

ANTIINFECTIVE AGENT; BIOTENE; GLUCOSE OXIDASE; LACTOFERRIN; LACTOPEROXIDASE; LYSOZYME; ORAL BALANCE; POLYMER; SALIVA SUBSTITUTE;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DENTAL CARE; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; FEMALE; HUMAN; MALE; PILOT STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SICKNESS IMPACT PROFILE; XEROSTOMIA;

AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; CROSS-OVER STUDIES; DENTAL CARE FOR AGED; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; GLUCOSE OXIDASE; HUMANS; LACTOFERRIN; LACTOPEROXIDASE; MALE; MURAMIDASE; PILOT PROJECTS; POLYMERS; QUALITY OF LIFE; SALIVA, ARTIFICIAL; SICKNESS IMPACT PROFILE; XEROSTOMIA;

EID: 43249118931     PISSN: 07340664     EISSN: 17412358     Source Type: Journal    
DOI: 10.1111/j.1741-2358.2007.00197.x     Document Type: Article

References (28)

1. Ship JA, Pillemer SR, Baum BJ. Xerostomia and the geriatric patient. J Am Geriatr Soc 2002 50 : 535 543.
2. Thompson WM. Issues in the epidemiological investigation of dry mouth. Gerodontology 2005 22 : 65 76.
3. Ship J, Baum BJ. Is reduced salivary floor normal in old people? Lancet 1990 336 : 1507.
4. Nederfors T, Isaksson R, Mornstad H et al. Prevalence of perceived symptoms of dry mouth in an adult Swedish population: relation to age, sex and pharmacotherapy. Community Dent Oral Epidemiol 1997 25 : 211 216.
5. Daniels TE, Wu AJ. Xerostomia: clinical evaluation and treatment in general practice. J Calif Dent Assoc 2000 28 : 933 941.
6. Schein OD, Hochberg MC, Munoz B et al. Dry eye and dry mouth in the elderly: a population-based assessment. Arch Intern Med 1999 159 : 1359 1363.
7. Bergdahl M, Bergdahl J. Low unstimulated salivary flow and subjective oral dryness: association with medication, anxiety, depression, and stress. J Dent Res 2000 79 : 1652 1658.
8. Nederfors T, Ericsson T, Twetman S et al. Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human parotid and submandibular-sublingual salivary secretion. J Dent Res 1994 73 : 5 10.
9. Cannon RD, Chaffin WL. Oral colonization by Candida albicans. Crit Rev Oral Biol Med 1999 10 : 359 383.
10. Greenspan B. Xerostomia: diagnosis and management. Oncology 1996 10 (Suppl. 7 11.
11. Scully C, Felix DH. Oral medicine update for the dental practitioner. Dry mouth and disorders of salivation. Br Dent J 2005 199 : 423 427.
12. Alves MB, Motta AC, Messina WC et al. Saliva substitute in xerostomic patients with primary Sjögren's syndrome: a single-blind trial. Quintessence Int 2004 35 : 392 396.
13. Tenovuo J. Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safety. Oral Dis 2002 8 : 23 29.
14. Bánóczy JB, Dombi C, Czegledly A et al. A clinical study with lactoperoxidase-containing gel and toothpaste in patients with dry mouth syndrome. J Clin Dent 1994 5 : 65 69.
15. Van Steenberghe D, Van den Eynde E, Jacobs R et al. Effect of a lactoperoxidase containing toothpaste in radiation-induced xerostomia. Int Dent J 1994 44 : 133 138.
16. Kirstila V, Lenander-Lumikari M, Soderling E et al. Effects of oral hygiene products containing lactoperoxidase, lysozyme, and lactoferrin on the composition of whole saliva and on subjective oral symptoms in patients with xerostomia. Acta Odontol Scand 1996 54 : 391 397.
17. Lenander-Lumikari M, Mikola H, Tenovuo J. Effects of a lactoperoxidase system-containing toothpaste on levels of hypothiocyanite and bacteria in saliva. Caries Res 1993 27 : 285 291.
18. Kirstila V, Lenander-Lumikari M, Tenovuo J. Effects of a lactoperoxidase system-containing toothpaste on dental plaque and whole saliva in vivo. Acta Odontol Scand 1994 52 : 346 353.
19. Epstein JB, Emerton S, Le ND et al. A double-blind crossover trial of Oral Balance gel and Biotene toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncol 1999 35 : 132 137.
20. Warde P, Kroll B, O'Sullivan B et al. A phase II study of Biotene in the treatment of postradiation xerostomia in patients with head and neck cancer. Support Care Cancer 2000 8 : 203 208.
21. Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil 2007 34 : 724 732.
22. Gresham GE, Philips TS, Labi MLC. ADL status in stroke: relative merits of three standard indexes. Arch Phys Med Rehabil 1980 61 : 355 358.
23. Locker D, Allen PF. Developing short-form measures of oral health-related quality of life. J Public Health Dent 2002 62 : 13 20.
24. Webb BC, Thomas CJ, Whittle T. A two-year study of Candida-associated denture stomatitis treatment in aged care subjects. Gerodontology 2005 22 : 168 176.
25. Thomson WM, Spencer AJ, Slade GD et al. Is medication a risk factor for dental caries among older people? Community Dent Oral Epidemiol 2002 30 : 224 232.
26. Hunter KD, Wilson WS. The effects of antidepressant drugs on salivary flow and content of sodium and potassium ions in human parotid saliva. Arch Oral Biol 1995 40 : 983 989.
27. Trindade E, Menon D, Topfer LA et al. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. CMAJ 1998 159 : 1245 1252.
28. Jacobsen FM, Comas-Diaz L. Donezepil for psychotropic-induced memory loss. J Clin Psychiatry 1999 60 : 698 704.