Effects of oral hygiene products containing lactoperoxidase, lysozyme, and lactoferrin on the composition of whole saliva and on subjective oral symptoms in patients with xerostomia

Acta Odontologica Scandinavica

Volumn 54, Issue 6, 1996, Pages 391-397

  Kirstilä, Varpuleena ^a   Lenander Lumikari, Marianne ^a   Söderling, Eva ^a   Tenovuo, Jorma ^a,b  

^a Turku University   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

antimicrobial agents; mouthrinse; saliva; toothpaste; xerostomia

Indexed keywords

BIOTENE; LACTOFERRIN; LACTOPEROXIDASE; LYSOZYME; TOOTHPASTE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BACTERIAL FLORA; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFECT; FEMALE; HUMAN; MALE; MOUTH HYGIENE; SALIVA; SYMPTOMATOLOGY; TOPICAL DRUG ADMINISTRATION; XEROSTOMIA;

EID: 0029749147     PISSN: 00016357     EISSN: None     Source Type: Journal    
DOI: 10.3109/00016359609003557     Document Type: Article

References (47)

1. Baum BJ. Salivary gland function during aging. Gerodontics 1986;2:61-4.
2. Herrera JL, Lyons MF, Johnson LF. Saliva: its role in health and disease. J Clin Gastroenterol 1988;10:569-78.
3. Mandel ID. The functions of saliva. J Dent Res 1987;66:623-7.
4. Brandtzaeg P. Salivary immunoglobulins. In: Tenovuo J, editor. Human saliva: clinical chemistry and microbiology. Vol II. Boca Raton (FL): CRC Press, 1989:1-54.
5. Mandel ID. Oral defenses and disease: salivary gland function. Gerodontology 1984;3:47-54.
6. Tenovuo J, Gråhn E, Lehtonen O-P, Hyyppa T, Karhuvaara L, Vilja P. Antimicrobial factors in saliva: ontogeny and relation to oral health. J Dent Res 1987;66:475-9.
7. Atkinson JC, Wu AJ. Salivary gland dysfunction: causes, symptoms, treatment. J Am Dent Assoc 1994;125:409-16.
8. Närhi TO. Prevalence of subjective feelings of dry mouth in the elderly. J Dent Res 1994;73:20-5.
9. Sreebny LM, Valdini A. Xerostomia. I. Relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol 1988;66:451-8.
10. Sreebny LM, Valdini A. Xerostomia. II. Relationship to nonoral symptoms, drugs, and diseases. Oral Surg Oral Med Oral Pathol 1989;68:419-27.
11. Fox PC, van der Ven PF, Sonies BC, Weiffenbach JM, Baum BJ. Xerostomia: evaluation of a symptom with increasing significance. J Am Dent Assoc 1985;110:519-25.
12. Fox PC, Busch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc 1987;115:581-4.
13. Nederfors T, Isaksson R, Mörnstad H, Dahlöf C. Prevalence of dry mouth and dry eyes in an adult Swedish population. J Dent Res 1994;73:420.
14. Sreebny LM. Recognition and treatment of salivary induced conditions. Int Dent J 1989;39:197-204.
15. Jenkins GN, Edgar W. The effect of daily gum-chewing on salivary flow rates in man. J Dent Res 1989;68:786-90.
16. Levine MJ. Development of artificial salivas. Crit Rev Oral Biol Med 1993;4:279-86.
17. Tenovuo J, Söderling E. Chemical aids in the prevention of dental diseases in the elderly. Int Dent J 1992;42:355-64.
18. Tenovuo J, Lumikari M, Soukka T. Salivary lysozyme, lactoferrin and peroxidases: antibacterial effects on cariogenic bacteria and clinical applications in preventive dentistry. Proc Finn Dent Soc 1991;87:197-208.
19. Thomas EL. Lactoperoxidase-catalyzed oxidation of thiocyanate: equilibria between oxidized forms of thiocyanate. Biochemistry 1981;20:3273-80.
20. Månsson-Rahemtulla B, Baldone DC, Pruitt KM, Rahcmtulla F. Effects of variations in pH and hypothiocyanite concentrations on S. mutans glucose metabolism. J Dent Res 1987;66:486-91.
21. Lumikari M, Soukka T, Nurmio S, Tenovuo J. Inhibition of the growth of Streptococcus mutans, Streptococcus sobrinus and Lactobacillus casei by oral peroxidase systems in human saliva. Arch Oral Biol 1991;36:155-60.
22. Pruitt KM, Tenovuo J, Fleming W, Adamson M. Limiting factors for the generation of hypothiocyanite ion, an antimicrobial agent, in human saliva. Caries Res 1982;16:315-23.
23. Månsson-Rahemtulla B, Pruitt KM, Tenovuo J, Le TM. A mouthrinse which optimizes in vivo generation of hypothiocyanite. J Dent Res 1983;62:1062-6.
24. Lenander-Lumikari M, Mikola H, Tenovuo J. Effects of a lactoperoxidase system-containing toothpaste on levels of hypothiocyanite and bacteria in saliva. Caries Res 1993;27: 285-91.
25. Kirstila V, Lenander-Lumikari M, Tenovuo J. Effects of a lactoperoxidase-system-containing toothpaste on dental plaque and whole saliva in vivo. Acta Odontol Scand 1994;52:346-53.
26. van Steenberghe D, Van den Eynde E, Jacobs R, Quirynen M. Effect of a lactoperoxidase containing toothpaste in radiation-induced xerostomia. Int Dent J 1994;44:133-8.
27. Banoczy JB, Dombi C, Czegledly A, Sari K. A clinical study with lactoperoxidase-containing gel and toothpaste in patients with dry mouth syndrome. J Clin Dent 1994;5:65-9.
28. Scully C Sjögren's syndrome: clinical and laboratory features, immunopathogenesis, and management. Oral Surg Oral Med Oral Pathol 1986;62:510-23.
29. Pruitt KM, Tenovuo J, Månsson-Rahemtulla B, Harrington P, Baldone DC. Is thiocyanate peroxidation at equilibrium in vivo? Biochim Biophys Acta 1986;870:385-91.
30. Betts RH, Dainton FS. Electron transfer and other processes involved in the spontaneous bleaching of acidified solutions of ferric thiocyanate. J Am Chem Soc 1953;73:5721-7.
31. Vilja P, Krohn K. Tuohimaa P. A rapid and sensitive non-competitive avidin-biotin assay for lactoferrin. J Immunol Methods 1982;76:73-83.
32. Wever R, Kast WM, Kasinoedin JH, Boelens R. The peroxidation of thiocyanate catalysed by myeloperoxidase and lactoperoxidase. Biochim Biophys Acta 1982;709:212-9.
33. Månsson-Rahemtulla B, Baldone DC, Pruitt KM, Rahemtulla F. Specific assays for peroxidases in human saliva. Arch Oral Biol 1986;31:661-8.
34. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:263-75.
35. Spielman AI. Interaction of saliva and taste. J Dent Res 1990;69:838-43.
36. Papas AS, Joshi A, MacDonald SL, Maravelis-Spagounais L, Pretara-Spanedda P, Curro FA. Caries prevalence in xerostomic individuals. J Can Dent Assoc 1993;59:171-9.
37. Gråhn E, Tenovuo J, Lehtonen O-P, Eerola E, Vilja P. Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults. Acta Odontol Scand 1988;46:67-74.
38. Tenovuo J. Oral defense factors in the elderly. Endod Dent Traumatol 1992;8:93-8.
39. Herlofson BB, Barkvoll P. Sodium lauryl sulfate and recurrent aphtous ulcers. A preliminary study. Acta Odontol Scand 1994; 52:257-9.
40. Mulligan R, Navazesh M, Slots J. Antibacterial activity of an alcohol-free mouthwash with enzymes [abstract]. J Dent Res 1992;71:156.
41. Pruitt KM, Reiter B. Biochemistry of peroxidase system: antimicrobial effects. In: Pruitt KM, Tenovuo J, editors. The lactoperoxidase system, chemistry and biological significance. New York: Marcel Dekker Inc , 1985:143-78.
42. Courtois P, Van Beeres D, De Foor M, Mandelbaum IM, Pourtois M. Abolition of Herpes simplex cytopathic effect after treatment with peroxidase generated hypothiocyanite. J Biol Buccale 1990;18:71-4.
43. Mikola H, Waris M, Tenovuo J. Inhibition of herpes simplex virus type 1, respiratory syncytial virus and echovirus type 11 by peroxidase-generated hypothiocyanite. Antiviral Res 1995; 26: 161-71.
44. Pourtois M, Binet C, Van Tieghem N, Vandenabbeele A, Thiry L. Inhibition of HIV infectivity by lactoperoxidase-produced hypothiocyanite. J Biol Buccale 1990;18:251-3.
45. Hanstrom L, Johansson A, Carlsson J. Lactoperoxidase and thiocyanate protect cultured mammalian cells against hydrogen peroxide toxicity. Med Biol 1983;61:268-74.
46. 3H-thymidine by human gingival fibroblasts cultured in vitro. Arch Oral Biol 1984;29:445-51.
47. Carlsson J, Iwami Y, Yamada T. Hydrogen peroxide excretion by oral streptococci and effect of lactoperoxidase-thiocyanate-hydrogen peroxide. Infect Immun 1983;40:70-80.