Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus

Epilepsia

Volumn 49, Issue 5, 2008, Pages 914-920

  Kanter, Ines C ^a   Huttner, Hagen B ^a   Staykov, Dimitre ^a   Biermann, Teresa ^a   Struffert, Tobias ^a   Kerling, Frank ^a   Hilz, Max Josef ^a   Schellinger, Peter D ^a   Schwab, Stefan ^a   Bardutzky, Jürgen ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Anti GAD antibodies; Cyclophosphamide; Epilepsy; Intrathecal GAD Ab synthesis

Indexed keywords

4 AMINOBUTYRIC ACID; CYCLOPHOSPHAMIDE; GLUTAMATE DECARBOXYLASE ANTIBODY; LAMOTRIGINE; PHENYTOIN; TOPIRAMATE; VALPROIC ACID;

ADULT; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CASE REPORT; CATALYSIS; CENTRAL NERVOUS SYSTEM; DISEASE ASSOCIATION; EPILEPTIC STATE; FEMALE; HUMAN; IMMUNOMODULATION; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; ANTICONVULSANTS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BRAIN; CYCLOPHOSPHAMIDE; DRUG RESISTANCE; EPILEPSY, COMPLEX PARTIAL; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, SPINAL; MAGNETIC RESONANCE IMAGING; STATUS EPILEPTICUS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 43249095163     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01500.x     Document Type: Article

References (16)

1. Crom WR, Glynn-Barnhart AM, Rodman JH, Teresi ME, Kavanagh RE, Christensen ML, Relling MV, Evans WE 1987) Pharmacokinetics of anticancer drugs in children. Clin Pharmacokinet 12 : 168 213.
2. Dalakas MC, Li M, Fujii M, Jacobowitz DM 2001) Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 57 : 780 784.
3. Dinkel K, Meinck HM, Jury KM, Karges W, Richter W 1998) Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome. Ann Neurol 44 : 194 201.
4. Giometto B, Nicolao P, Macucci M, Tavolato B, Foxon R, Bottazzo GF 1998) Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies. Lancet 352 : 457.
5. Hsu CC, Davis KM, Jin H, Foos T, Floor E, Chen W, Tyburski JB, Yang CY, Schloss JV, Wu JY 2000) Association of L-glutamic acid decarboxylase to the 70-kDa heat shock protein as a potential anchoring mechanism to synaptic vesicles. J Biol Chem 275 : 20822 20828.
6. Kwan P, Sills GJ, Kelly K, Butler E, Brodie MJ 2000) Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Res 42 : 191 195.
7. Levy LM, Dalakas MC, Floeter MK 1999) The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann Intern Med 131 : 522 530.
8. McKnight K, Jiang Y, Hart Y, Cavey A, Wroe S, Blank M, Shoenfeld Y, Vincent A, Palace J, Lang B 2005) Serum antibodies in epilepsy and seizure-associated disorders. Neurology 65 : 1730 1736.
9. Mitoma H, Song SY, Ishida K, Yamakuni T, Kobayashi T, Mizusawa H 2000) Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. J Neurol Sci 175 : 40 44.
10. Nemni R, Braghi S, Natali-Sora MG, Lampasona V, Bonifacio E, Comi G, Canal N 1994) Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy. Ann Neurol 36 : 665 667.
11. Peltola J, Kulmala P, Isojarvi J, Saiz A, Latvala K, Palmio J, Savola K, Knip M, Keranen T, Graus F 2000) Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurology 55 : 46 50.
12. Sokol DK, McIntyre JA, Wagenknecht DR, Dropcho EJ, Patel H, Salanova V, da Costa G 2004) Antiphospholipid and glutamic acid decarboxylase antibodies in patients with focal epilepsy. Neurology 62 : 517 518.
13. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P 1990) Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 322 : 1555 1560.
14. Vianello M, Tavolato B, Armani M, Giometto B 2003) Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies. Cerebellum 2 : 77 79.
15. Vulliemoz S, Vanini G, Truffert A, Chizzolini C, Seeck M 2007) Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies. J Neurol Neurosurg Psychiatry 78 : 187 189.
16. Yoshimoto T, Doi M, Fukai N, Izumiyama H, Wago T, Minami I, Uchimura I, Hirata Y 2005) Type 1 diabetes mellitus and drug-resistant epilepsy: presence of high titer of anti-glutamic acid decarboxylase autoantibodies in serum and cerebrospinal fluid. Intern Med 44 : 1174 1177.