The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H 1-receptor-PKC-MAPK signalling pathway

Inflammation Research

Volumn 57, Issue SUPPL. 1, 2008, Pages

  Ales K ^a   Wraber, B ^b   Lipnik Stangelj M ^a  

^a Department of Pharmacology and Experimental Toxicology ^*  (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; HISTAMINE; HISTAMINE H1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MEPYRAMINE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ASTROCYTE; CELL CULTURE; CONFERENCE PAPER; CYTOKINE RELEASE; DRUG MECHANISM; INCUBATION TIME; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; ASTROCYTES; CELLS, CULTURED; ENZYME INHIBITORS; HISTAMINE; HISTAMINE ANTAGONISTS; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; PROTEIN KINASE C; PYRILAMINE; RATS; RATS, WISTAR; RECEPTORS, HISTAMINE H1;

EID: 43249083376     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-0617-z     Document Type: Conference Paper

References (8)

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3. Lipnik-Stangelj M, Carman-Krzan M. Histamine-stimulated nerve growth factor secretion from cultured astrocytes is blocked by protein kinase C inhibitors. Inflamm Res 2004; 53: S57-8.
4. Lipnik-Stangelj M, Carman-Krzan M. Effects of histamine and IL-1beta on PKC-stimulated nerve growth factor secretion from glial cells. Inflamm Res 2006; 55: S34-5.
5. Lipnik-Stangelj M, Carman-Krzan M. Histamine and IL-6 interaction in the stimulation of nerve growth factor secretion from cultured astrocytes. Inflamm Res 2005; 54: S36-7.
6. Lipnik-Stangelj M, Carman-Krzan M. The effects of histamine and interleukin-6 on NGF release from cortical astrocytes in primary culture. Pflugers Arch 2000; 440 (Suppl): R99-100.
7. Falus A, Grosman N, Darvas Z. Histamine: Biology and Medical Aspects. Basel: Karger & Budapest: SpringMed Publishing, 2004.
8. Carman-Kržan M, Vige X, Wise BC. Regulation by interleukin-1 of nerve growth factor secretion and nerve growth factor mRNA expression in rat primary astroglial cultures. J Neurochem 1991; 56: 636-43.