Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory

PLoS ONE

Volumn 2, Issue 11, 2007, Pages

  Pavard, Samuel ^a,b   Metcalf, C Jessica E ^a,c  

^a MAX PLANCK INSTITUTE FOR DEMOGRAPHIC RESEARCH   (Germany)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN;

AGING; ALLELE; ALZHEIMER DISEASE; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FAMILIAL CANCER; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; MENOPAUSE; ONSET AGE; OVARY CANCER; PLEIOTROPY; POPULATION GENETICS; DEMOGRAPHY; GENETIC PREDISPOSITION; MUTATION; THEORETICAL MODEL; TUMOR SUPPRESSOR GENE;

AGE OF ONSET; DEMOGRAPHY; FEMALE; GENES, BRCA1; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HUMANS; MODELS, THEORETICAL; MUTATION;

EID: 43149121837     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001206     Document Type: Article

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