Up-regulation of vimentin expression in low-density malignant glioma cells as immediate and late effects under irradiation and temozolomide treatment

Amino Acids

Volumn 34, Issue 4, 2008, Pages 539-545

  Trog, Daniela ^a   Yeghiazaryan, Kristina ^a   Schild, Hans H ^a   Golubnitschaja, Olga ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Human malignant gliomas; Pro invasive molecular marker; Simulation of clinical glioma treatment; Temozolomide therapy; Vimentin expression patterns

Indexed keywords

PROTEIN P53; TEMOZOLOMIDE; TUMOR MARKER; VIMENTIN;

ARTICLE; CANCER INVASION; CANCER RADIOTHERAPY; CELL DENSITY; CELL SURVIVAL; CHEMOTHERAPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOTHERAPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMULATION; TREATMENT RESPONSE; TUMOR CELL CULTURE; TUMOR LOCALIZATION; UPREGULATION;

ALGORITHMS; CELL COUNT; GENE EXPRESSION REGULATION; GLIOMA; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TIME FACTORS; TUMOR CELLS, CULTURED; UP-REGULATION; VIMENTIN; X-RAYS;

EID: 43149120651     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-007-0007-4     Document Type: Article

References (15)

1. Arab S, Rutka J, Lingwood C (1999) Verotoxin induces apoptosis and the complete, rapid, long-term elimination of human astrocytoma xenografts in nude mice. Oncol Res 11:33-39
2. Dehghani F, Schachenmayr W, Laun A, Korf HW (1998) Prognostic implication of histopathological, immunohistochemical and clinical features of oligodendrogliomas: a study of 89 cases. Acta Neuropathol 95:493-504
3. Hegedus B, Zach J, Czirok A, Lovey J, Vicsek T (2004) Irradiation and Taxol treatment result in non-monotonous, dose-dependent changes in the motility of glioblastoma cells. J Neurooncol 67:147-157
4. Heid CA, Stevens J, Livak KJ, Williams PM (1996) Real time quantitative PCR. Genome Res 6:986-994
5. Horiguchi H, Sano T, Hirose T (2001) TP53 deleted cells in de novo glioblastomas using fluorescence in situ hybridization. Pathol Int 51:187-192
6. Mahesparan R, Read T A, Lund-Johansen M, Skaftnesmo KO, Bjerkvig R, Engebraaten O (2003) Expression of extracellular matrix components in a highly infiltrative in vivo glioma model. Acta Neuropathol 105:49-57
7. Provenzale JM, York G, Moya MG, Parks L, Choma M, Kealey S, Cole P, Serajuddin H (2006) Correlation of relative permeability and relative cerebral blood volume in high-grade cerebral neoplasms. AJR Am J Roentgenol 187:1036-1042
8. Rutka JT, Ivanchuk S, Mondal S, Taylor M, Sakai K, Dirks P, Jun P, Jung S, Becker LE, Ackerley C (1999) Co-expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells. Int J Dev Neurosci 17:503-515
9. Sallinen SL, Sallinen PK, Haapasalo HK, Helin HJ, Helen PT, Schraml P, Kallioniemi OP, Kononen J (2000) Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res 60:6617-6622
10. Trog D, Yeghiazaryan K, Fountoulakis M, Friedlein A, Moenkemann H, Haertel N, Schueller H, Breipohl W, Schild H, Leppert D, Golubnitschaja O (2006a) Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells. Eur J Pharmacol 542:8-15
11. Trog D, Fountoulakis M, Friedlein A, Golubnitschaja O (2006b) Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions. Proteomics 6:2924-2930
12. Trog D, Moenkemann H, Breipohl W, Schueller H, Schild H, Golubnitschaja O (2007a) Non-sufficient cell cycle control as possible clue for the resistance of human malignant glioma cells to clinically relevant treatment conditions. Amino Acids 32:373-379
13. Trog D, Yeghiazaryan K, Schild H, Golubnitschaja O (2007b) Pro-invasive molecular events in human malignant glioma cells strongly depend on algorithm of chemo/radio treatment, cellular density, and drug delivery. Eur J Pharmacol (accepted)
14. van Meter T, Dumur C, Hafez N, Garrett C, Fillmore H, Broaddus WC (2006) Microarray analysis of MRI-defined tissue samples in glioblastoma reveals differences in regional expression of therapeutic targets. Diagn Mol Pathol 15:195-205
15. Wild-Bode C, Weller M, Rimner A, Dichgans J, Wick W (2001) Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res 61:2744-2750