TP53 deleted cells in de novo glioblastomas using fluorescence in situ hybridization

Pathology International

Volumn 51, Issue 3, 2001, Pages 187-192

  Horiguchi, Hidehisa ^a   Sano, Toshiaki ^a   Hirose, Takanori ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

de novo glioblastoma; Fluorescence in situ hybridization; MIB 1; P53 protein; TP53

Indexed keywords

GENE PRODUCT; KI 67 ANTIGEN; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL SUBPOPULATION; CENTROMERE; CLINICAL ARTICLE; FEMALE; FLUORESCENCE; GENE DELETION; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LABELING INDEX; MALE; PRIORITY JOURNAL;

ADULT; AGED; CELL COUNT; CELL NUCLEUS; CENTROMERE; FEMALE; GENE DELETION; GENES, P53; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KI-67 ANTIGEN; MALE; MIDDLE AGED; MUTATION; NEOPLASM STAGING; SUPRATENTORIAL NEOPLASMS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035060865     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2001.01186.x     Document Type: Article

References (35)

1. A genetic model for colorectal tumorigenesis
2. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
3. Mutations in the p53 gene occur in diverse human tumour types
4. Clonal expansion of p53 mutant cells is associated with brain tumour progression
5. p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma
6. The p53 gene and protein in human brain tumors
7. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression
8. Subsets of glioblastoma multiforme defined by molecular genetic analysis
9. A tiger behind many doors: Multiple genetic pathways to malignant glioma
10. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
11. A molecular genetic model of astrocytoma. Histopathology
12. Pathology and genetics
13. Genetics of glioblastoma progression and the definition of primary and secondary glioblastoma
14. Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas
15. Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma
16. Prognostic implications of p53 overexpression in supratentorial astrocytic tumors
17. Prognostic significance of p53 immunoreactivity in adult patients with supratentorial fibrillary astrocytic neoplasms
18. Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: Relationships and prognostic value
19. A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme
20. Comparative study of p53 gene and protein alterations in human astrocytic tumors
21. Accumulation of wild-type p53 protein in human astrocytomas
22. Pattern of Mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis
23. Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas
24. Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and Sphase fraction using archival paraffin-embedded samples
25. Accumulation of p53 and Ki-67 expression do not predict survival in patients with fibrillary astrocytomas or the response of these tumors to radiotherapy
26. Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression
27. Interphase cytogenesis of glioblastoma and gliosarcoma
28. Detection of structural aberrations of chromosome 17 in malignant gliomas by fluorescence in situ hybridization (FISH)
29. Use of fluorescence in situ hybridization to detect loss of chromosome 10 in astrocytomas
30. Histological typing of tumours of the central nervous system
31. Alteration of TP53 gene in human gliomas
32. Molecular analysis of microdissected de novo glioblastomas and paired astrocytic tumors
33. Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells
34. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
35. p53 integrating the complexity