Is asthma in childhood different from asthma in adults? Why do we need special approaches to asthma in children?

Allergy and Asthma Proceedings

Volumn 29, Issue 2, 2008, Pages 99-102

  Gelfand, Erwin W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Adult asthma; Aeroallergen sensitization; Childhood asthma; Corticosteroid; Lung function; Manifestations; Therapeutic

Indexed keywords

ALLERGEN; ANTIASTHMATIC AGENT; CORTICOSTEROID; CYTOKINE;

ADULT; AGING; ANIMAL; ASTHMA; CHILD; CONFERENCE PAPER; HUMAN; IMMUNOLOGY; INFANT; PATHOPHYSIOLOGY; PRESCHOOL CHILD;

ADRENAL CORTEX HORMONES; ADULT; AGING; ALLERGENS; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; CYTOKINES; HUMANS; INFANT;

EID: 43149117049     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: 10.2500/aap.2008.29.3090     Document Type: Conference Paper

References (30)

1. Kraft M, Djukanovic R, Wilson S, et al. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 154:1505-1510, 1996.
2. Kraft M, Djukanovic R, Wilson S, et al. Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma. Am J Respir Crit Care Med 159:228-234, 1999.
3. Wenzel SE, Szefler SJ, Leung DYM, et al. Bronchoscopic evaluation of severe asthma: Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 156:737-743, 1997.
4. Elias JA, Zhu Z, Chupp G, et al. Airway remodeling in asthma. J Clin Invest 104:1001-1006, 2000.
5. Hegele RG, and Hogg JC. The pathology of asthma: An inflammatory disorder. In Severe Asthma: Pathogenesis and Clinical Management, Vol. 86. Szefler SJ, and Leung DYM (Eds). New York: Marcel Dekker, 61-76, 1996.
6. Jenkins HA, Cherniack R, Szefler SJ, et al. A comparison of the clinical characteristics of children and adults with severe asthma. Chest 124:1318-1324, 2003.
7. Spahn JD, CovarRA, Jain N, et al. Effect of montelukast on peripheral airflow obstruction in children with asthma. Ann Allergy Asthma Immunol 96:541-549, 2006.
8. Spahn JD, Cherniack R, Paull K, and Gelfand EW. Is the forced expiratory volume in one second the best measure of asthma severity in childhood asthma? Am J Respir Crit Care Med 169:784-786, 2004.
9. Fuhlbrigge AL, Kitch BT, Paltiel AD, et al. FEV1 is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol 107:61-67, 2001.
10. Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 343:1054-1063, 2000.
11. Bacharier LB, Strunk RC, Mauger D, et al. Classifying asthma severity in children: Mismatch between symptoms, medication use, and lung function. Am J Respir Crit Care Med 170:426-432, 2004.
12. Hogg JC, Macklem PT, and Thurlbeck WM. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 278:1355-1360, 1968.
13. Paull K, Covar R, Jain N, et al. Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center 1999-2000. Pediatr Pulm 39:311-317, 2005.
14. Jenkins HA, Cool C, Szefler SJ, et al. Histopathology of severe childhood asthma: A case series. Chest 124:32-41, 2003.
15. Busse WW, Banks-Schlegal S, and Wenzel SE. Pathophysiology of severe asthma. J Clin Immunol 106:1033-1042, 2000.
16. Editorial: A plea to abandon asthma as a disease concept. Lancet 368:705, 2006.
17. Yunginger J, Reed CE, O'Connell EJ, et al. A community-based study of the epidemiology of asthma: Incidence rates 1964-1983. Am Rev Respir Dis 146:888-894, 1992.
18. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 349:1414-1422, 2003.
19. Taube C, Dakhama A, and Gelfand EW. Insights into the pathogenesis of asthma utilizing murine models. Int Arch Allergy Immunol 135:173-186, 2004.
20. Gelfand EW, Joetham A, Cui Z-H, et al. Induction and maintenance of airway responsiveness to allergen challenge is determined at the age of initial sensitization. J Immunol 173:1298-1306, 2004.
21. Dakhama A, Park JW, Taube C, et al. The enhancement or prevention of airway hyperresponsiveness during re-infection with respiratory syncytial virus is critically dependent on the age at first infection and interleukin-13 production. J Immunol 175:1876-1883, 2005.
22. Morgan WJ, Stern DA, Sherrill DL, et al. Outcome of asthma and wheezing in the first 6 years of life: Follow-up through adolescence. Am J Respir Crit Care Med 172:1253-1258, 2005.
23. Illi S, von Mutius E, Lau S, et al. Perennial allergen sensitization early in life and chronic asthma in children: A birth cohort study. Lancet 368:763-770, 2006.
24. Woodcock A, Lowe LA, Murray CS, et al. Early life environmental control: Effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med 170:433-439, 2004.
25. Koopman LP, van Strien RT, Kerkhof M, et al. Placebo-controlled trial of house dust mite-impermeable mattress covers: Effect on symptoms in early childhood. Am J Respir Crit Care Med 166:307-313, 2002.
26. Murray CS, Woodcock A, Langley SJ, and the IFWIN Study Team. Secondary prevention of asthma by the use of inhaled fluticasone propionate in wheezy infants (IFWIN): Double-blind, randomized, controlled study. Lancet 368:754-762, 2006.
27. Guilbert W, Morgan WJ, Zeiger RS, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 354:1985-1997, 2006.
28. Bisgaard H, Hermansen MN, Loland L, et al. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 354:1998-2005, 2006.
29. The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 343:1054-1063, 2000.
30. Covar RA, Spahn JD, Murphy JR, and Szefler SJ. Progression of asthma measured by lung function in the Childhood Asthma Management Program. Am J Respir Crit Care Med 170:234-241, 2004.