Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth

Nuclear Medicine and Biology

Volumn 32, Issue 7, 2005, Pages 695-700

  Dadachova, Ekaterina ^a   Nguyen, Andrew ^a   Lin, Elaine Y ^a   Gnatovskiy, Leo ^a   Lu, Ping ^a   Pollard, Jeffrey W ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer; Iodine 131; NIS; PyMT mouse model; Rhenium 188; Therapy

Indexed keywords

IODINE 131; RHENIUM 188;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; BREAST TUMOR; CONTROLLED STUDY; MAMMARY GLAND; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; SCINTIGRAPHY; THYROID FUNCTION; TUMOR GROWTH;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FEMALE; IODINE RADIOISOTOPES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; RADIOISOTOPES; RADIOPHARMACEUTICALS; RHENIUM; SYMPORTERS; TREATMENT OUTCOME;

EID: 27144519982     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.05.007     Document Type: Article

References (15)

1. U.H. Tazebay, I.L. Wapnir, O. Levy, O. Dohan, L.S. Zuckier, and Q.H. Zhao The mammary gland iodide transporter is expressed during lactation and in breast cancer Nat Med 6 2000 871 878
2. M.T. Kilbane, R.A. Ajjan, A.P. Weetman, R. Dwyer, E.W. McDermott, and N.J. O'Higgins Tissue iodine content and serum-mediated 125-I uptake-blocking activity in breast cancer J Clin Endocrinol Metab 85 2000 1245 1250
3. I.L. Wapnir, M. van de Rijn, K. Nowels, P.S. Amenta, K. Walton, and K. Montgomery Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections J Clin Endocrinol Metab 88 2003 1880 1888
4. O. Dohan, A. De La Vieja, V. Paroder, C. Riedel, M. Artani, and M. Reed The sodium/iodide symporter (NIS): characterization, regulation, and medical significance Endocr Rev 24 2003 48 77
5. 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues Nucl Med Biol 28 2001 829 834
6. - symporter Clin Cancer Res 10 2004 4294 4302
7. J. Van Sande, C. Massart, R. Beauwens, A. Schoutens, S. Costagliola, and J.E. Dumont Anion selectivity by the sodium iodide symporter Endocrinology 144 2003 247 252
8. L.S. Zuckier, O. Dohan, Y. Li, N. Carrasco, and E. Dadachova Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate and iodide by NIS-expressing tissues in vivo J Nucl Med 45 2004 500 507
9. E. Dadachova, B. Bouzahzah, L.S. Zuckier, and R.G. Pestell Rhenium-188 as an alternative to iodine-131 for treatment of breast tumors expressing the sodium/iodide symporter (NIS) Nucl Med Biol 29 2002 13 18
10. 188Re generator for biomedical applications Radiochim Acta 65 1994 39 46
11. E.Y. Lin, J.G. Jones, P. Li, L. Zhu, K.D. Whitney, and W.J. Muller Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases Am J Pathol 163 2003 2113 2126
12. K.A. Knostman, J.Y. Cho, K.Y. Ryu, X. Lin, J.A. McCubrey, and T. Hla Signaling through 3′,5′-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer J Clin Endocrinol Metab 89 2004 5196 5203
13. H. Gullberg, M. Rudling, D. Forrest, B. Angelin, and B. Vennstrom Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol Mol Endocrinol 14 2000 1739 1749
14. E. Dadachova, and N. Carrasco The Na/I symporter (NIS): imaging and therapeutic applications Semin Nucl Med 34 2004 23 31
15. J.A. O'Donoghue, M. Bardiès, and T.E. Wheldon Relationship between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides J Nucl Med 36 1995 1902 1909