Association of increased active PTH(1-84) fraction with decreased GFR and serum Ca in predialysis CRF patients: Modulation by serum 25-OH-D

Osteoporosis International

Volumn 19, Issue 5, 2008, Pages 709-716

  Kurajoh, M ^a   Inaba, M ^a   Yamada, S ^a   Imanishi, Y ^a   Tsuchida, T ^a   Ishimura, E ^a   Nishizawa, Y ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone marker; Intact PTH; Predialysis chronic renal failure; PTH (1 84); PTH (7 84) like fragment; Serum 25 OH D; Whole PTH

Indexed keywords

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; AMINO TERMINAL TELOPEPTIDE; CALCIFEDIOL; CALCIUM; PARATHYROID HORMONE;

AGED; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM METABOLISM; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DIALYSIS; FEMALE; GLOMERULUS FILTRATION RATE; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; UREMIA; VITAMIN D DEFICIENCY;

AGED; BIOLOGICAL MARKERS; BONE DENSITY; BONE DISEASES, METABOLIC; BONE REMODELING; CALCIUM; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PARATHYROID HORMONE; REGRESSION ANALYSIS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 43149107434     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-007-0554-2     Document Type: Article

References (33)

1. John MR, Goodman WG, Gao P, Cantor TL, Salusky IB, Juppner H (1999) A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure. J Clin Endocrinol Metab 84:4287-4290
2. Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C, D'Amour P (1998) A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin Chem 44:805-809
3. Brossard JH, Lepage R, Cardinal H, Roy L, Rousseau L, Dorais C, D'Amour P (2000) Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays. Clin Chem 46:697-703
4. Brossard JH, Cloutier M, Roy L, Lepage R, Gascon-Barre M, D'Amour P (1996) Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values. J Clin Endocrinol Metab 81:3923-3929
5. Inaba M, Okuno S, Imanishi Y, Ueda M, Yamakawa T, Ishimura E, Nishizawa Y (2005) Significance of Bio-intact PTH(1-84) assay in hemodialysis patients. Osteoporos Int 16:517-525
6. Kawata T, Imanishi Y, Kobayashi K, Onoda N, Takemoto Y, Tahara H, Okuno S, Ishimura E, Miki T, Ishikawa T, Inaba M, Nishizawa Y (2005) Direct in vitro evidence of extracellular Ca2+-induced amino-terminal truncation of human parathyroid hormone (1-84) by human parathyroid cells. J Clin Endocrinol Metab 90:5774-5778
7. Inaba M, Terada M, Nishizawa Y, Shioi A, Ishimura E, Otani S, Morii H (1999) Protective effect of an aldose reductase inhibitor against bone loss in galactose-fed rats: possible involvement of the polyol pathway in bone metabolism. Metabolismo 48:904-909
8. Ishimura E, Nishizawa Y, Inaba M, Matsumoto N, Emoto M, Kawagishi T, Shoji S, Okuno S, Kim M, Miki T, Morii H (1999) Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney Int 55:1019-1027
9. (1992) The Modification of Diet in Renal Disease Study: design, methods, and results from the feasibility study. Am J Kidney Dis 20:18-33
10. Babazono T, Hanai K, Suzuki K, Kiuchi Y, Inoue A, Tanaka M, Tanaka N, Hase M, Ishii A, Iwamoto Y (2006) Lower haemoglobin level and subsequent decline in kidney function in type 2 diabetic adults without clinical albuminuria. Diabetologia 49:1387-1393
11. Inaba M, Nishizawa Y, Mita K, Kumeda Y, Emoto M, Kawagishi T, Ishimura E, Nakatsuka K, Shioi A, Morii H (1999) Poor glycemic control impairs the response of biochemical parameters of bone formation and resorption to exogenous 1,25-dihydroxyvitamin D3 in patients with type 2 diabetes. Osteoporos Int 9:525-531
12. Kumeda Y, Inaba M, Tahara H, Kurioka Y, Ishikawa T, Morii H, Nishizawa Y (2000) Persistent increase in bone turnover in Graves' patients with subclinical hyperthyroidism. J Clin Endocrinol Metab 85:4157-4161
13. Ohashi T, Igarashi Y, Mochizuki Y, Miura T, Inaba N, Katayama K, Tomonaga T, Nomura F (2007) Development of a novel fragments absorbed immunocapture enzyme assay system for tartrate-resistant acid phosphatase 5b. Clin Chim Acta 376:205-212
14. Gertz BJ, Clemens JD, Holland SD, Yuan W, Greenspan S (1998) Application of a new serum assay for type I collagen cross-linked N-telopeptides: assessment of diurnal changes in bone turnover with and without alendronate treatment. Calcif Tissue Int 63:102-106
15. Clemens JD, Herrick MV, Singer FR, Eyre DR (1997) Evidence that serum NTx (collagen-type I N-telopeptides) can act as an immunochemical marker of bone resorption. Clin Chem 43:2058-2063
16. Gomez B Jr, Ardakani S, Ju J, Jenkins D, Cerelli MJ, Daniloff GY, Kung VT (1995) Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum. Clin Chem 41:1560-1566
17. Gao P, Scheibel S, D'Amour P, John MR, Rao SD, Schmidt-Gayk H, Cantor TL (2001) Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res 16:605-614
18. Souberbielle JC, Boutten A, Carlier MC, Chevenne D, Coumaros G, Lawson-Body E, Massart C, Monge M, Myara J, Parent X, Plouvier E, Houillier P (2006) Inter-method variability in PTH measurement: implication for the care of CKD patients. Kidney Int 70:345-350
19. Inaba M, Nakatsuka K, Imanishi Y, Watanabe M, Mamiya Y, Ishimura E, Nishizawa Y (2004) Technical and clinical characterization of the Bio-PTH (1-84) immunochemiluminometric assay and comparison with a second-generation assay for parathyroid hormone. Clin Chem 50:385-390
20. Reichel H, Esser A, Roth HJ, Schmidt-Gayk H (2003) Influence of PTH assay methodology on differential diagnosis of renal bone disease. Nephrol Dial Transplant 18:759-768
21. Roth HJ (2000) Elecsys parathyroid hormone (PTH) not detecting the large PTH fragment hPTH (7-84)? Clin Lab 46:295-299
22. Hiroyuki Y, Motomiya Y, Uchida K, Akizawa T (2002) Development and clinical application of Whole PTH (PTH1-84) kit. Jpn J Med Pharm Sci 48:243-247
23. Inomata K, Yamashita H, Yamamoto A, Yukishita M, Adachi M (2004) Influence of 25-hydroxyvitamin D concentration on the reference range of intact PTH. Osteoporosis Jpn 12:449-456
24. Harinarayan CV (2005) Prevalence of vitamin D insufficiency in postmenopausal south Indian women. Osteoporos Int 16:397-402
25. Saquib N, von Muhlen D, Garland CF, Barrett-Connor E (2006) Serum 25-hydroxyvitamin D, parathyroid hormone, and bone mineral density in men: the Rancho Bernardo study. Osteoporos Int 17:1734-1741
26. Yamamoto T, Ozono K, Shima M, Yamaoka K, Okada S (1998) 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res 244:71-76
27. Moosgaard B, Vestergaard P, Heickendorff L, Melsen F, Christiansen P, Mosekilde L (2006) Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study. Eur J Endocrinol 155:237-244
28. Eastwood JB, Stamp TC, De Wardener HE, Bordier PJ, Arnaud CD (1977) The effect of 25-hydroxy vitamin D3 in the osteomalacia of chronic renal failure. Clin Sci Mol Med 52:499-508
29. Ghazali A, Fardellone P, Pruna A, Atik A, Achard JM, Oprisiu R, Brazier M, Remond A, Moriniere P, Garabedian M, Eastwood J, Fournier A (1999) Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? Kidney Int 55:2169-2177
30. Tsukamoto Y, Watanabe T, Nakagami T, Morishita K (2003) Effect of treatment with oral calcitriol on calcium metabolism and fasting serum 25(OH)- or 1,25(OH)2-vitamin D level in Japanese postmenopausal women. Endocr J 50:681-687
31. Matsumoto T, Ikeda K, Yamato H, Morita K, Ezawa I, Fukushima M, Nishii Y, Ogata E (1988) Effect of 24,25-dihydroxyvitamin D3 on 1,25-dihydroxyvitamin D3 metabolism in calcium-deficient rats. Biochem J 250:671-677
32. Ritter CS, Armbrecht HJ, Slatopolsky E, Brown AJ (2006) 25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int 70:654-659
33. Kates DM, Sherrard DJ, Andress DL (1997) Evidence that serum phosphate is independently associated with serum PTH in patients with chronic renal failure. Am J Kidney Dis 30:809-813