Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data

Cancer Genetics and Cytogenetics

Volumn 183, Issue 1, 2008, Pages 21-27

  Rouzier, Cécile ^a   Haudebourg, Juliette ^b   Carpentier, Xavier ^b   Valério, Laure ^c   Amiel, Jean ^b   Michiels, Jean François ^b   Pedeutour, Florence ^a  

^a UNIVERSITY HOSPITAL OF NICE   (France)

^b PASTEUR HOSPITAL   (France)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CONTROLLED STUDY; ETS GENE; FUSION GENE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TMPRSS2 GENE;

ADENOCARCINOMA; ADENOVIRUS E1A PROTEINS; AGED; AGED, 80 AND OVER; DNA-BINDING PROTEINS; FEASIBILITY STUDIES; FIXATIVES; FORMALDEHYDE; HUMANS; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PARAFFIN EMBEDDING; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERINE ENDOPEPTIDASES; TRANSCRIPTION FACTORS;

EID: 43049152935     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.01.021     Document Type: Article

References (29)

1. Mitelman F. Recurrent chromosome aberrations in cancer. Mutat Res 462 (2000) 247-253
2. Kroll T.G., Sarraf P., Pecciarini L., Chen C.J., Mueller E., Spiegelman B.M., and Fletcher J.A. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma. [corrected]. Science 289 (2000) 1357-1360
3. Sidhar S.K., Clark J., Gill S., Hamoudi R., Crew A.J., Gwilliam R., Ross M., Linehan W.M., Birdsall S., Shipley J., and Cooper C.S. The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. Hum Mol Genet 5 (1996) 1333-1338
4. Argani P., Lui M.Y., Couturier J., Bouvier R., Fournet J.C., and Ladanyi M. A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23). Oncogene 22 (2003) 5374-5378
5. Tognon C., Knezevich S.R., Huntsman D., Roskelley C.D., Melnyk N., Mathers J.A., Becker L., Carneiro F., MacPherson N., Horsman D., Poremba C., and Sorensen P.H. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2 (2002) 367-376
6. Mitelman F., Johansson B., and Mertens F. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet 36 (2004) 331-334
7. Tomlins S.A., Rhodes D.R., Perner S., Dhanasekaran S.M., Mehra R., Sun X.W., Varambally S., Cao X., Tchinda J., Kuefer R., Lee C., Montie J.E., Shah R.B., Pienta K.J., Rubin M.A., and Chinnaiyan A.M. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310 (2005) 644-648
8. Soller M.J., Isaksson M., Elfving P., Soller W., Lundgren R., and Panagopoulos I. Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer. Genes Chromosomes Cancer 45 (2006) 717-719
9. Yoshimoto M., Joshua A.M., Chilton-Macneill S., Bayani J., Selvarajah S., Evans A.J., Zielenska M., and Squire J.A. Three-Color FISH Analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. Neoplasia 8 (2006) 465-469
10. Wang J., Cai Y., Ren C., and Ittmann M. Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer. Cancer Res 66 (2006) 8347-8351
11. Tomlins S.A., Mehra R., Rhodes D.R., Smith L.R., Roulston D., Helgeson B.E., Cao X., Wei J.T., Rubin M.A., Shah R.B., and Chinnaiyan A.M. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res 66 (2006) 3396-3400
12. TNM Classification of Malignant Tumours. 6th edition (2002), John Wiley & Sons, Hoboken, New Jersey
13. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs (2004), IARC Press, Lyon
14. Clark J., Merson S., Jhavar S., Flohr P., Edwards S., Foster C.S., Eeles R., Martin F.L., Phillips D.H., Crundwell M., Christmas T., Thompson A., Fisher C., Kovacs G., and Cooper C.S. Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene 26 (April 19, 2007) 2667-2673
15. Mehra R., Tomlins S.A., Shen R., Nadeem O., Wang L., Wei J.T., Pienta K.J., Ghosh D., Rubin M.A., Chinnaiyan A.M., and Shah R.B. Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. Mod Pathol 20 (2007) 538-544
16. Tu J.J., Rohan S., Kao J., Kitabayashi N., Mathew S., and Chen Y.T. Gene fusions between TMPRSS2 and ETS family genes in prostate cancer. Frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. Mod Pathol 20 (2007) 921-928
17. Bianchini L., Maire G., and Pedeutour F. From cytogenetics to cytogenomics of dermatofibrosarcoma protuberans family of tumors. Bull Cancer 94 (2007) 179-189
18. Cook J.R., Hartke M., Pettay J., and Tubbs R.R. Fluorescence in situ hybridization analysis of immunoglobulin heavy chain translocations in plasma cell myeloma using intact paraffin sections and simultaneous CD138 immunofluorescence. J Mol Diagn 8 (2006) 459-465
19. Dhanasekaran S.M., Barrette T.R., Ghosh D., Shah R., Varambally S., Kurachi K., Pienta K.J., Rubin M.A., and Chinnaiyan A.M. Delineation of prognostic biomarkers in prostate cancer. Nature 412 (2001) 822-826
20. Singh D., Febbo P.G., Ross K., Jackson D.G., Manola J., Ladd C., Tamayo P., Renshaw A.A., D'Amico A.V., Richie J.P., Lander E.S., Loda M., Kantoff P.W., Golub T.R., and Sellers W.R. Gene expression correlates of clinical prostate cancer behavior. Cancer Cell 1 (2002) 203-209
21. Quinn D.I., Henshall S.M., and Sutherland R.L. Molecular markers of prostate cancer outcome. Eur J Cancer 41 (2005) 858-887
22. Dong J.T., Chen C., Stultz B.G., Isaacs J.T., and Frierson Jr. H.F. Deletion at 13q21 is associated with aggressive prostate cancers. Cancer Res 60 (2000) 3880-3883
23. Harkonen P., Kyllonen A.P., Nordling S., and Vihko P. Loss of heterozygosity in chromosomal region 16q24.3 associated with progression of prostate cancer. Prostate 62 (2005) 267-274
24. Takahashi S., Shan A.L., Ritland S.R., Delacey K.A., Bostwick D.G., Lieber M.M., Thibodeau S.N., and Jenkins R.B. Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression. Cancer Res 55 (1995) 4114-4119
25. Petrovics G., Liu A., Shaheduzzaman S., Furasato B., Sun C., Chen Y., Nau M., Ravindranath L., Chen Y., Dobi A., Srikantan V., Sesterhenn I.A., McLeod D.G., Vahey M., Moul J.W., and Srivastava S. Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome. Oncogene 24 (2005) 3847-3852
26. Kibel AS. TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort Demichelis F, Fall K, Perner S, Andren O, Schmidt F, Setlur SR, Hoshida Y, Mosquera JM, Pawitan Y, Lee C, Adami HO, Mucci LA, Kantoff PW, Andersson SO, Chinnaiyan AM, Johansson JE, Rubin MA, Department of Pathology, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; and Bioinformatics Group, SRA, ITC-irst, Trento, Italy. Urol Oncol 2007;25:448-9.
27. Perner S., Demichelis F., Beroukhim R., Schmidt F.H., Mosquera J.M., Setlur S., Tchinda J., Tomlins S.A., Hofer M.D., Pienta K.G., Kuefer R., Vessella R., Sun X.W., Meyerson M., Lee C., Sellers W.R., Chinnaiyan A.M., and Rubin M.A. TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res 66 (2006) 8337-8341
28. Lapointe J., Kim Y.H., Miller M.A., Li C., Kaygusuz G., van de Rijn M., Huntsman D.G., Brooks J.D., and Pollack J.R. A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. Mod Pathol 20 (2007) 467-473
29. Cerveira N., Ribeiro F.R., Peixoto A., Costa V., Henrique R., Jeronimo C., and Teixeira M.R. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia 8 (2006) 826-832