Effects of an extra X chromosome on language lateralization: An fMRI study with Klinefelter men (47,XXY)

Schizophrenia Research

Volumn 101, Issue 1-3, 2008, Pages 17-25

  van Rijn, Sophie ^a,b,d   Aleman, André ^c   Swaab, Hanna ^b,d   Vink, Matthijs ^b   Sommer, Iris ^b   Kahn, René S ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Asymmetry; Schizophrenia; Sex chromosomes; Superior temporal gyrus; Thought disorder; XXY karyotype

Indexed keywords

ADULT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DISORIENTATION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMISPHERIC DOMINANCE; HUMAN; INTERVIEW; KARYOTYPE 47,XXY; KLINEFELTER SYNDROME; LANGUAGE; LANGUAGE DISABILITY; MALE; MENTAL FUNCTION; PRIORITY JOURNAL; QUESTIONNAIRE; SUPERIOR TEMPORAL GYRUS; SUPERNUMERARY CHROMOSOME; SUPRAMARGINAL GYRUS; THOUGHT DISORDER; X CHROMOSOME;

ADULT; BRAIN; BRAIN MAPPING; CHROMOSOMES, HUMAN, X; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KLINEFELTER SYNDROME; LANGUAGE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXYGEN; PERSONALITY INVENTORY; SCHIZOPHRENIC PSYCHOLOGY;

EID: 43049146124     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2008.02.001     Document Type: Article

References (39)

1. Beeman M.J., and Chiarello C. Complementary right- and left-hemisphere language comprehension. Curr. Dir. Psychol. Sci. 7 1 (1998) 2-8
2. Bojesen A., Juul S., Birkebaek N.H., and Gravholt C.H. Morbidity in klinefelter syndrome; a danish register study based on hospital discharge diagnoses. J. Clin. Endocrinol. Metab. 91 4 (2006) 1254-1260
3. Boks M.P.M., de Vette M.H.T., Sommer I.E., van Rijn S., Giltay J.C., Swaab H., and Kahn R.S. Psychiatric morbidity and x-chromosomal origin in a klinefelter sample. Schizophr. Res. 93 1-3 (2007) 399-402
4. Crow T.J. Cerebral asymmetry and the lateralization of language: Core deficits in schizophrenia as pointers to the gene. Curr. Opin. Psychiatry 17 2 (2004) 97-106
5. Davies W., and Wilkinson L.S. It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Res. 1126 1 (2006) 36-45
6. DeLisi L.E., Friedrich U., Wahlstrom J., Boccio-Smith A., Forsman A., Eklund K., and Crow T.J. Schizophrenia and sex chromosome anomalies. Schizophr. Bull. 20 3 (1994) 495-505
7. DeLisi L.E., Maurizio A.M., Svetina C., Ardekani B., Szulc K., Nierenberg J., Leonard J., and Harvey P.D. Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders. Am. J. Med. Genet. B Neuropsychiatr. Genet. 135 1 (2005) 15-23
8. Dewing P., Shi T., Horvath S., and Vilain E. Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Mol. Brain Res. 118 1-2 (2003) 82-90
9. Dollfus S., Razafimandimby A., Delamillieure P., Brazo P., Joliot M., Mazoyer B., and Tzourio-Mazoyer N. Atypical hemispheric specialization for language in right-handed schizophrenia patients. Biol. Psychiatry 57 9 (2005) 1020-1028
10. Geschwind D.H., Gregg J., Boone K., Karrim J., Pawlikowska Haddal A., Rao E., Ellison J., Ciccodicola A., D_Urso M., Woods R., Rappold G.A., Swerdloff R., and Nelson S.F. Klinefelter's syndrome as a model of anomalous cerebral laterality: Testing gene dosage in the x chromosome pseudoautosomal region using a DNA microarray. Dev. Genet. 23 3 (1998) 215-229
11. Geschwind D.H., Boone K.B., Miller B.L., and Swerdloff R.S. Neurobehavioral phenotype of klinefelter syndrome. Ment. Retard. Dev. Disabil. Res. Rev. 6 2 (2000) 107-116
12. Itti E., Gaw Gonzalo I.T., Boone K.B., Geschwind D.H., Berman N., Pawlikowska-Haddal A., Itti L., Mishkin F.S., and Swerdloff R.S. Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with klinefelter's syndrome. Ann. Neurol. 54 5 (2003) 669-673
13. Itti E., Gaw Gonzalo I.T., Pawlikowska-Haddal A., Boone K.B., Mlikotic A., Itti L., Mishkin F.S., and Swerdloff R.S. The structural brain correlates of cognitive deficits in adults with klinefelter's syndrome. J. Clin. Endocrinol. Metab. 91 4 (2006) 1423-1427
14. Kay S.R., Fiszbein A., and Opler L.A. The positive and negative syndrome rating scale (panss) for schizophrenia. Schizophr. Bull. 13 (1987) 261-276
15. Kircher T.T.J., Liddle P.F., Brammer M.J., Williams S.C.R., Murray R.M., and McGuire P.K. Reversed lateralization of temporal activation during speech production in thought disordered patients with schizophrenia. Psychol. Med. 32 3 (2002) 439-449
16. Li X., Branch C.A., Ardekani B.A., Bertisch H., Hicks C., and DeLisi L.E. Fmri study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk. Schizophr. Res. 96 1-3 (2007) 14-24
17. Maldjian J.A., Laurienti P.J., Kraft R.A., and Burdette J.H. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fmri data sets. Neuroimage 19 3 (2003) 1233-1239
18. Matsumoto H., Simmons A., Williams S., Hadjulis M., Pipe R., Murray R., and Frangou S. Superior temporal gyrus abnormalities in early-onset schizophrenia: Similarities and differences with adult-onset schizophrenia. Am. J. Psychiatr. 158 8 (2001) 1299-1304
19. Menon R.R., Barta P.E., Aylward E.H., Richards S.S., Vaughn D.D., Tien A.Y., Harris G.J., and Pearlson G.D. Posterior superior temporal gyrus in schizophrenia: Grey matter changes and clinical correlates. Schizophr. Res. 16 2 (1995) 127-135
20. Mitchell R.L.C., and Crow T.J. Right hemisphere language functions and schizophrenia: The forgotten hemisphere?. Brain 128 5 (2005) 963-978
21. Netley C., and Rovet J. Hemispheric lateralization in 47,xxy klinefelter's syndrome boys. Brain Cogn. 3 1 (1984) 10-18
22. Oldfield R.C. The assessment and analysis of handedness: The edinburgh inventory. Neuropsychologia 9 1 (1971) 97-113
23. Patwardhan A.J., Eliez S., Bender B., Linden M.G., and Reiss A.L. Brain morphology in klinefelter syndrome: Extra X chromosome and testosterone supplementation. Neurology 54 12 (2000) 2218-2223
24. Raine A. The spq: A scale for the assessment of schizotypal personality based on dsm-iii-r criteria. Schizophr. Bull. 17 4 (1991) 555-564
25. Rajarethinam R.P., DeQuardo J.R., Nalepa R., and Tandon R. Superior temporal gyrus in schizophrenia: A volumetric magnetic resonance imaging study. Schizophr. Res. 41 2 (2000) 303-312
26. Ramsey N.F., Van Den Brink J.S., Van Muiswinkel A.M.C., Folkers P.J.M., Moonen C.T.W., Jansma J.M., and Kahn R.S. Phase navigator correction in 3d fmri improves detection of brain activation: Quantitative assessment with a graded motor activation procedure. Neuroimage 8 3 (1998) 240-248
27. Ramsey N.F., Sommer I.E., Rutten G.J., and Kahn R.S. Combined analysis of language tasks in fmri improves assessment of hemispheric dominance for language functions in individual subjects. Neuroimage 13 4 (2001) 719-733
28. Rossi A., Serio A., Stratta P., Petruzzi C., Schiazza G., Mancini F., and Casacchia M. Planum temporale asymmetry and thought disorder in schizophrenia. Schizophr. Res. 12 1 (1994) 1-7
29. Samango-Sprouse C. Mental development in polysomy x klinefelter syndrome (47,xxy; 48,xxxy): Effects of incomplete x inactivation. Semin. Reprod. Med. 19 2 (2001) 193-202
30. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., and Dunbar G.C. The mini-international neuropsychiatric interview (m.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for dsm-iv and icd-10. J. Clin. Psychiatry 59 Suppl 20 (1998) 22-33 quiz 34-57
31. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., Hokama H., Martin J., Metcalf D., and Coleman M. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med. 327 9 (1992) 604-612
32. Sommer I., Aleman A., Ramsey N., Bouma A., and Kahn R. Handedness, language lateralisation and anatomical asymmetry in schizophrenia: Meta-analysis. Br. J. Psychiatry 178 (2001) 344-351 (APR.)
33. Sommer I.E., Ramsey N.F., and Kahn R.S. Language lateralization in schizophrenia, an fmri study. Schizophr. Res. 52 1-2 (2001) 57-67
34. Sommer I.E.C., Cohen-Kettenis P.T., Van Raalten T., van der Veer A.J., Gooren L.J.G., Kahn R.S., and Ramsey N.F. No effects of cross-sex hormones on cerebral lateralization: An fmri study in transsexuals. Eur. Neuropsychopharmacol. 18 3 (2008) 215-221
35. Van Rijn S., Aleman A., Swaab H., and Kahn R. Klinefelter's syndrome (karyotype 47,xxy) and schizophrenia-spectrum pathology. Br. J. Psychiatry 189 5 (2006) 459-461
36. Van Rijn S., Swaab H., Aleman A., and Kahn R.S. X chromosomal effects on social cognitive processing and emotion regulation: A study with klinefelter men (47,xxy). Schizophr. Res. 84 2-3 (2006) 194-203
37. Van Rijn S., Aleman A., Swaab H., Krijn T., Vingerhoets G., and Khan R. What is said versus how it is said: comprehension of affective prosody in men with Klinefelter (47,XXY) syndrome. J. Int. Neuropsychol. Soc. 13 6 (2007) 1065-1070
38. Vollema M.G., and Hoijtink H. The multidimensionality of self-report schizotypy in a psychiatric population: An analysis using multidimensional rasch models. Schizophr. Bull. 26 3 (2000) 565-575
39. Wisniewski A.B., Prendeville M.T., and Dobs A.S. Handedness, functional cerebral hemispheric lateralization, and cognition in male-to-female transsexuals receiving cross-sex hormone treatment. Arch. Sex Behav. 34 2 (2005) 167-172