C6-peptide serology as diagnostic tool in neuroborreliosis

APMIS

Volumn 116, Issue 5, 2008, Pages 393-399

  Tjernberg, Ivar ^a,b   Schön, Thomas ^a   Ernerudh, Jan ^b   Wistedt, Annika Carlsson ^a   Forsberg, Pia ^b   Eliasson, Ingvar ^c  

^a KALMAR COUNTY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cerebrospinal fluid; Intrathecal antibodies; Lyme neuroborreliosis; Pleocytosis; Serology

Indexed keywords

BACTERIUM ANTIBODY; BORRELIA ANTIBODY; C6 PEPTIDE; PEPTIDE;

ADOLESCENT; ADULT; AGED; ARTICLE; BORRELIA INFECTION; BRAIN INFECTION; CEREBROSPINAL FLUID ANALYSIS; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC KIT; DIAGNOSTIC VALUE; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; HUMAN; LUMBAR PUNCTURE; MALE; PLEOCYTOSIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SWEDEN; SYMPTOM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BORRELIA BURGDORFERI; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INCIDENCE; LIPOPROTEINS; LYME NEUROBORRELIOSIS; MALE; MIDDLE AGED; PEPTIDES; RETROSPECTIVE STUDIES; SEROLOGIC TESTS;

EID: 43049138377     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2008.00842.x     Document Type: Article

References (24)

1. Stanek G, Strle F. Lyme borreliosis. Lancet 2003 362 : 1639 47.
2. Luostarinen L, Heinonen T, Luostarinen M, Salmivaara A. Diagnostic lumbar puncture. Comparative study between 22-gauge pencil point and sharp bevel needle. J Headache Pain 2005 6 : 400 4.
3. Brouqui P, Bacellar F, Baranton G, Birtles RJ, Bjöersdorff A, Blanco JR, et al. Guidelines for the diagnosis of tick-borne bacterial diseases in Europe. Clin Microbiol Infect 2004 10 : 1108 32.
4. Liang FT, Aberer E, Cinco M, Gern L, Hu CM, Lobet YN, et al. Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL. J Infect Dis 2000 182 : 1455 62.
5. Liang FT, Steere AC, Marques AR, Johnson BJ, Miller JN, Philipp MT. Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi VlsE. J Clin Microbiol 1999 37 : 3990 6.
6. Philipp MT, Bowers LC, Fawcett PT, Jacobs MB, Liang FT, Marques AR, et al. Antibody response to IR6, a conserved immunodominant region of the VlsE lipoprotein, wanes rapidly after antibiotic treatment of Borrelia burgdorferi infection in experimental animals and in humans. J Infect Dis 2001 184 : 870 8.
7. Panelius J, Lahdenne P, Saxen H, Carlsson SA, Heikkila T, Peltomaa M, et al. Diagnosis of Lyme neuroborreliosis with antibodies to recombinant proteins DbpA, BBK32, and OspC, and VlsE IR6 peptide. J Neurol 2003 250 : 1318 27.
8. Peltomaa M, McHugh G, Steere AC. The VlsE (IR6) peptide ELISA in the serodiagnosis of lyme facial paralysis. Otol Neurotol 2004 25 : 838 41.
9. Tjernberg I, Krüger G, Eliasson I. C6 peptide ELISA test in the serodiagnosis of Lyme borreliosis in Sweden. Eur J Clin Microbiol Infect Dis 2007 26 : 37 42.
10. Cinco M, Murgia R. Evaluation of the C6 enzyme-linked immunoadsorbent assay for the serodiagnosis of Lyme borreliosis in north-eastern Italy. New Microbiol 2006 29 : 139 41.
11. Smismans A, Goossens VJ, Nulens E, Bruggeman CA. Comparison of five different immunoassays for the detection of Borrelia burgdorferi IgM and IgG antibodies. Clin Microbiol Infect 2006 12 : 648 55.
12. Sillanpää H, Lahdenne P, Sarvas H, Arnez M, Steere A, Peltomaa M, et al. Immune responses to borrelial VlsE IR6 peptide variants. Int J Med Microbiol 2007 297 : 45 52.
13. Skarpaas T, Ljøstad U, Søbye M, Mygland A. Sensitivity and specificity of a commercial C6 peptide enzyme immuno assay in diagnosis of acute Lyme neuroborreliosis. Eur J Clin Microbiol Infect Dis 2007 26 : 675 7.
14. Nyman D, Willén L, Jansson C, Carlsson SA, Granlund H, Wahlberg P. VlsE C6 peptide and IgG ELISA antibody analysis for clinical diagnosis of Lyme borreliosis in an endemic area. Clin Microbiol Infect 2006 12 : 496 7.
15. Schauer U, Stemberg F, Rieger CH, Buttner W, Borte M, Schubert S, et al. Levels of antibodies specific to tetanus toxoid, Haemophilus influenzae type b, and pneumococcal capsular polysaccharide in healthy children and adults. Clin Diagn Lab Immunol 2003 10 : 202 7.
16. Schauer U, Stemberg F, Rieger CH, Borte M, Schubert S, Riedel F, et al. IgG subclass concentrations in certified reference material 470 and reference values for children and adults determined with the binding site reagents. Clin Chem 2003 49 : 1924 9.
17. TM Lyme Neuroborreliosis. DakoCytomation : Cambridgeshire, United Kingdom, 2005.
18. TM C6 Borrelia assay kit. Immunetics Inc. : Cambridge, MA, USA, 2004.
19. Widhe M, Jarefors S, Ekerfelt C, Vrethem M, Bergstrom S, Forsberg P, et al. Borrelia-specific interferon-gamma and interleukin-4 secretion in cerebrospinal fluid and blood during Lyme borreliosis in humans: association with clinical outcome. J Infect Dis 2004 189 : 1881 91.
20. Strle F, Ruzic-Sabljic E, Cimperman J, Lotric-Furlan S, Maraspin V. Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid. Clin Infect Dis 2006 43 : 704 10.
21. Widhe M, Skogman BH, Jarefors S, Eknefelt M, Enestrom G, Nordwall M, et al. Up-regulation of Borrelia-specific IL-4- and IFN-gamma-secreting cells in cerebrospinal fluid from children with Lyme neuroborreliosis. Int Immunol 2005 17 : 1283 91.
22. Berglund J, Stjernberg L, Ornstein K, Tykesson-Joelsson K, Walter H. 5-y Follow-up study of patients with neuroborreliosis. Scand J Infect Dis 2002 34 : 421 5.
23. Göttner G, Schulte-Spechtel U, Wilske B. Heterogeneity of the immunodominant surface protein VlsE among the three genospecies of Borrelia burgdorferi pathogenic for humans. Int J Med Microbiol 2004 37 (Suppl 172 3.
24. Goettner G, Schulte-Spechtel U, Hillermann R, Liegl G, Wilske B, Fingerle V. Improvement of Lyme borreliosis serodiagnosis by a newly developed recombinant immunoglobulin G (IgG) and IgM line immunoblot assay and addition of VlsE and DbpA homologues. J Clin Microbiol 2005 43 : 3602 9.