A directly stackable microsystem onto the cultured cells for cytotoxicity tests

Microsystem Technologies

Volumn 14, Issue 6, 2008, Pages 719-724

  Bang, Hyunwoo ^a   Lee, Won Gu ^a   Yun, Hoyoung ^a   Chung, Chanil ^b   Chang, Jun Keun ^b   Han, Dong Chul ^a  

^a Seoul National University   (South Korea)

^b Digital Bio Technology Co   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG PRODUCTS PLANTS; MICROSYSTEMS; REDUCTION;

MICROCHAMBERS; PHARMACEUTICAL INDUSTRY;

CYTOTOXICITY;

EID: 43049133212     PISSN: 09467076     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00542-007-0518-7     Document Type: Article

References (15)

1. Bang H, Lim SH, Lee YK, Chung S, Chung C, Han D-C, Chang JK (2004) Serial dilution microchip for cytotoxicity test. J Micromech Microeng 14:1165-1170
2. Bang H, Lee WG, Park J, Yun H, Lee J, Chung S, Cho K, Chung C, Han D-C, Chang JK (2006) Active sealing for soft polymer microchips: method and practical applications. J Micromech Microeng 16:708-714
3. Cantin AM, North SL, Fells GA, Hubbard RC, Crystal RG (1987) Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis. J Clin Invest 79:1665-1673
4. Chang JK, Heo YS, Bang H, Cho K, Chung S, Chung C, Han D-C (2003a) Functional integration of serial dilution and capillary electrophoresis on a PDMS microchip. Biotech Bioprocess Eng 8:33-239
5. Chang JK, Bang H, Park S-J, Chung S, Chung C, Han D-C (2003b) Fabrication of the PDMS microchip for serially diluting sample with buffer. Microsyst Technol 9:555-558
6. Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE (1997) Geometric control of cell life and death. Science 276:1425-1428
7. Dittrich PS, Schwille P (2003) An integrated microfluidic system for reaction, high-sensitivity detection, and sorting of fluorescent cells and particles. Anal Chem 75:5767-5774
8. Freshney I (2001) Application of cell cultures to toxicology. Cell Biol Toxicol 17:213-230
9. Jeon NL, Dertinger SKW, Chiu DT, Choi IS, Stroock AD, Whitesides GM (2000) Generation of solution and surface gradients using microfluidic systems. Langmuir 16:8311-8316
10. Ng MKJ, Gitlin I, Strook AD, Whitesides GM (2002) Components for integrated poly (dimethylsiloxane) microfluidic systems. Electrophoresis 23:3461-3473
11. Slater K (2001) Cytotoxicity tests for high-throughput drug discovery. Curr Opin Biotechnol 12:70-74
12. Suttorp N, Simon LM (1982) Lung cell oxidant injury: enhancement of polymorphonuclear leukocyte-mediated cytotoxicity in lung cells exposed to sustained in vitro hyperoxia. J Clin Invest 70:342-350
13. Thomas CH, Lhoest JB, Castner DG, McFarland CD, Healy KE (1999) Surfaces designed to control the projected area and shape of individual cells. J Biomech Eng 121:40-48
14. Weiss SJ, Young J, Lobuglio AF, Slivka A, Nimeh NF (1981) Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest 68:714-721
15. Xia Y, Whitesides GM (1998) Soft Lithography. Annu Rev Mater Sci 28:153-184