Receptor expression is essential for proliferation induced by dimerized Jak kinases

Biochemical and Biophysical Research Communications

Volumn 370, Issue 4, 2008, Pages 557-560

  Fujii, Hodaka ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemical dimerizer; Coumermycin; IL 2; IL 2R; Internal ligand; Jak kinases

Indexed keywords

COUMAMYCIN; CYTOKINE RECEPTOR; CYTOKINE RECEPTOR GAMMA CHAIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; JANUS KINASE 1; JANUS KINASE 3;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REACTION ANALYSIS; SIGNAL TRANSDUCTION;

AMINOCOUMARINS; ANIMALS; CELL PROLIFERATION; DIMERIZATION; HUMANS; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; JANUS KINASE 1; JANUS KINASE 3; MICE;

EID: 43049130282     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.095     Document Type: Article

References (20)

1. Russell S.M., Johnston J.A., Noguchi M., Kawamura M., Bacon C.M., Friedmann M., Berg M., McVicar D.W., Witthuhn B.A., Silvennoinen O., Goldman A.S., Schmalstieg F.C., Ihle J.N., O'Shea J.J., and Leonard W.J. Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266 (1994) 1042-1045
2. Miyazaki T., Kawahara A., Fujii H., Nakagawa Y., Minami Y., Liu Z.-J., Oishi I., Silvennoinen O., Witthuhn B.A., Ihle J.N., and Taniguchi T. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266 (1994) 1045-1047
3. Boussiotis V.A., Barber D.L., Nakarai T., Freeman G.J., Gribben J.G., Bernstein G.M., D'Andrea A.D., Ritz J., and Nadler L.M. Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor. Science 266 (1994) 1039-1042
4. Ihle J.N. STATs: signal transducers and activators of transcription. Cell 84 (1996) 331-334
5. Stark G.R., Kerr I.M., Williams B.R.G., Silverman R.H., and Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67 (1998) 227-264
6. Levy D.E., and Darnell Jr. J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3 (2002) 651-662
7. Kawahara A., Minami Y., Miyazaki T., Ihle J.N., and Taniguchi T. Critical role of the interleukin 2 (IL-2) receptor γ-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Proc. Natl. Acad. Sci. USA 92 (1995) 8724-8728
8. Tsujino S., Di Santo J.P., Takaoka A., McKernan T.L., Noguchi S., Taya C., Yonekawa H., Saito T., Taniguchi T., and Fujii H. Differential requirement of the cytoplasmic subregions of γc chain in T cell development and function. Proc. Natl. Acad. Sci. USA 97 (2000) 10514-10519
9. Tsujino S., Miyazaki T., Kawahara A., Maeda M., Taniguchi T., and Fujii H. Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor γc chain in the Jak3-independent signal transduction. Genes Cells 4 (1999) 363-373
10. Spencer D.M., Wandless T.J., Schreiber S.L., and Crabtree G.R. Controlling signal transduction with synthetic ligands. Science 262 (1993) 1019-1024
11. Farrar M.A., Alberol-Ila J., and Perlmutter R.M. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature 383 (1996) 178-181
12. Mizuguchi R., and Hatakeyama M. Conditional activation of Janus Kinase (JAK) confers factor independence upon interleukin-3-dependent cells. J. Biol. Chem. 273 (1998) 32297-32303
13. Mizuguchi R., Noto S., Yamada M., Ashizawa S., Higashi H., and Hatakeyama M. Ras and signal transducer and activator of transcription (STAT) are essential and sufficient downstream components of Janus kinases in cell proliferation. Jpn. J. Cancer Res. 91 (2000) 527-533
14. Hatakeyama M., Mori H., Doi T., and Taniguchi T. A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59 (1989) 837-845
15. Fujii H., Nakagawa Y., Schindler U., Kawahara A., Mori H., Gouilleux F., Groner B., Ihle J.N., Minami Y., Miyazaki T., and Taniguchi T. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92 (1995) 5482-5486
16. Hoshino A., Hirst J.A., and Fujii H. Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. J. Biol. Chem. 282 (2007) 17706-17711
17. Hoshino A., Matsumura S., Kondo K., Hirst J.A., and Fujii H. Inducible translocation trap: a system for detecting inducible nuclear translocation. Mol. Cell 15 (2004) 153-159
18. Hoshino A., Saint Fleur S., and Fujii H. Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain. Biochem. Biophys. Res. Commun. 346 (2006) 1062-1066
19. Hoshino A., and Fujii H. Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. FEBS Lett. 581 (2007) 975-980
20. Kawahara A., Minami Y., and Taniguchi T. Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor γ chain in IL-2, IL-4, and IL-7 signalling. Mol. Cell. Biol. 14 (1994) 5433-5440