Effects of estradiol and norethisterone on lipids, insulin resistance and carotid flow

Maturitas

Volumn 59, Issue 3, 2008, Pages 249-258

  Fernandes, Cesar E ^a   Pompei, Luciano M ^a   Machado, Rogério B ^b   Ferreira, José Arnaldo S ^a   Melo, Nilson R ^c   Peixoto, Sergio ^a,c  

^a FACULDADE DE MEDICINA DO ABC   (Brazil)

^b Faculty of Medicine of Jundiai   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cardiovascular risk; Diabetes; Estradiol; Hormone therapy; Menopause; Norethisterone

Indexed keywords

ESTRADIOL; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; NORETHISTERONE; PLACEBO;

ADULT; ARTICLE; CAROTID ARTERY FLOW; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; FEMALE; HORMONAL THERAPY; HOT FLUSH; HUMAN; INSULIN RESISTANCE; INTERNAL CAROTID ARTERY; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MASTALGIA; MENOPAUSAL SYNDROME; MONOTHERAPY; POSTMENOPAUSE; PULSATILE FLOW; RANDOMIZED CONTROLLED TRIAL; VAGINA BLEEDING; VASOCONSTRICTION; VASODILATATION;

CAROTID ARTERIES; CORONARY ARTERY DISEASE; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; INSULIN RESISTANCE; LIPIDS; MIDDLE AGED; NORETHINDRONE; PULSATILE FLOW;

EID: 43049123060     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2008.02.001     Document Type: Article

References (31)

1. ESHRE Capri Workshop Group. Hormones and cardiovascular health in women. Hum Reprod Update 12 (2006) 483-497
2. Dubey R.K., Imthurn B., Barton M., and Jackson E.K. Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen. Cardiovasc Res 66 (2005) 295-306
3. Carr M.C. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 88 (2003) 2404-2411
4. Schneider J.G., Tompkins C., Blumenthal R.S., and Mora S. The metabolic syndrome in women. Cardiol Rev 14 (2006) 286-291
5. Godsland I.F., Crook D., Simpson R., et al. The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. N Engl J Med 323 (1990) 1375-1381
6. Lau T.K., Wan D., Yim S.F., Sanderson J.E., and Haines C.J. Prospective, randomized, controlled study of the effect of hormone replacement therapy on peripheral blood flow velocity in postmenopausal women. Fertil Steril 70 (1998) 284-288
7. Friedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972) 499-502
8. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
9. Braun B., Rock P.B., Zamudio S., et al. Women at altitude: short-term exposure to hypoxia and/or α1-adrenergic blockade reduces insulin sensitivity. J Appl Physiol 91 (2001) 623-631
10. Stampfer M.J., Colditz G.A., Willett W.C., et al. Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med 325 (1991) 756-762
11. Manson J.E., Hsia J., Johnson K.C., et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349 (2003) 523-534
12. Salpeter S.R., Walsh J.M., Ormiston T.M., et al. Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women. Diab Obes Metab 8 5 (2006) 538-554
13. Slopien R., Junik R., Meczekalski B., et al. Influence of hormonal replacement therapy on the regional cerebral blood flow in postmenopausal women. Maturitas 46 4 (2003) 255-262
14. Lopez-Jaramillo P., Diaz L.A., Pardo A., et al. Estrogen therapy increases plasma concentrations of nitric oxide metabolites in postmenopausal women but increases flow-mediated vasodilation only in younger women. Fertil Steril 82 6 (2004) 1550-1555
15. Guo X., Razandi M., Pedram A., Kassab G., and Levin E.R. Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta. J Biol Chem 280 (2005) 19704-19710
16. Balci H., Altunyurt S., Acar B., Fadiloglu M., Kirkali G., and Onvural B. Effects of transdermal estrogen replacement therapy on plasma levels of nitric oxide and plasma lipids in postmenopausal women. Maturitas 50 (2005) 289-293
17. De Leo V., la Marca A., Orlandi R., Crippa D., Setacci C., and Petraglia F. Effects of estradiol alone or in combination with cyproterone acetate on carotid artery pulsatility index in postmenopausal women. Maturitas 46 (2003) 219-224
18. Atalay E., Karaali K., Akar M., et al. Early impact of hormone replacement therapy on vascular hemodynamics detected via ocular colour Doppler analysis. Maturitas 50 (2005) 282-288
19. Luckas M.J., Gleeve T., Biljan M.M., et al. The effect of progestagens on the carotid artery pulsatility index in postmenopausal women on oestrogen replacement therapy. Eur J Obstet Gynecol Reprod Biol 76 (1998) 221-224
20. Hsia J., Langer R.D., Manson J.E., et al. Conjugated equine estrogens and coronary heart disease: the women's health initiative. Arch Intern Med 166 (2006) 357-365
21. Spellacy W., McLeod A., Buhi W., and Birk S. Depot medroxyprogesterone acetate and carbohydrate metabolism: measurement of glucose, insulin and growth hormone after twelve months' use. Fertil Steril 23 (1972) 239-244
22. Lobo R.A., Bush T., Carr B.R., and Pickar J.H. Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism. Fertil Steril 76 (2001) 13-24
23. Arruda C.G., Aldrighi J.M., Bortolotto L.A., Alecrin I.N., and Ramires J.A. Effects of estradiol alone and combined with norethisterone acetate on pulse-wave velocity in hypertensive postmenopausal women. Gynecol Endocrinol 22 (2006) 557-563
24. Lazar Jr. F., Costa-Paiva L., Pinto-Neto A.M., and Martinez E.Z. Carotid and uterine vascular resistance in short-term hormone replacement therapy postmenopausal users. Maturitas 48 (2004) 472-478
25. Godsland I.F. Oestrogens and insulin secretion. Diabetologia 48 11 (2005) 2213-2220
26. Sites C.K., L'Hommedieu G.D., Toth M.J., Brochu M., Cooper B.C., and Fairhurst P.A. The effect of hormone replacement therapy on body composition, body fat distribution, and insulin sensitivity in menopausal women: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 90 (2005) 2701-2707
27. Elkind-Hirsch K.E., Sherman L.D., and Malinak R. Hormone replacement therapy alters insulin sensitivity in young women with premature ovarian failure. J Clin Endocrinol Metab 76 (1993) 472-475
28. Lindheim S.R., Duffy D.M., Kojima T., Vijod M.A., Stanczyk F.Z., and Lobo R.A. The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women. Fertil Steril 62 (1994) 1176-1180
29. Dansuk R., Unal O., Karsidag Y.K., and Turan C. Evaluation of the effects of various gestagens on insulin sensitivity, using homeostatic model assessment, in postmenopausal women on hormone replacement therapy. Gynecol Endocrinol 20 (2005) 1-5
30. Sumino H., Ichikawa S., Itoh H., et al. Hormone replacement therapy decreases insulin resistance and lipid metabolism in Japanese postmenopausal women with impaired and normal glucose tolerance. Horm Res 60 (2003) 134-142
31. Ishida Y., Mine T., and Taguchi T. Effect of progestins with different glucocorticoid activity on bone metabolism. Clin Endocrinol (Oxf) 68 3 (2008) 423-428