Acid and non-acid reflux patterns in patients with erosive esophagitis and non-erosive reflux disease (NERD): A study using intraluminal impedance monitoring

Digestive Diseases and Sciences

Volumn 53, Issue 6, 2008, Pages 1506-1512

  Conchillo, José M ^a   Schwartz, Matthijs P ^a   Selimah, Mohamed ^a   Samsom, Melvin ^a   Sifrim, Daniel ^b   Smout, André J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Acid reflux; Erosive esophagitis; Gastroesophageal reflux disease; Impedance monitoring; Non acid reflux; Non erosive reflux disease

Indexed keywords

ADULT; AGED; ARTICLE; CHEMICAL COMPOSITION; CLINICAL ARTICLE; ESOPHAGUS MANOMETRY; FEMALE; GAS; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL ENDOSCOPY; HUMAN; IMPEDANCE; INCIDENCE; LIQUID; MALE; NON EROSIVE REFLUX DISEASE; PH MEASUREMENT; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; STATISTICAL SIGNIFICANCE; SUPINE POSITION;

ADULT; AGED; ESOPHAGEAL PH MONITORING; ESOPHAGITIS, PEPTIC; ESOPHAGOSCOPY; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MANOMETRY; MIDDLE AGED; POSTURE; STATISTICS, NONPARAMETRIC;

EID: 43049122783     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-0059-z     Document Type: Article

References (25)

1. Fass S (2007) Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics. J Clin Gastroenterol 41:131-137
2. Dent J, Brun J, Fendrick AM, Fennerty MB, Janssens J, Kahrilas PJ et al (1999) An evidence-based appraisal of reflux disease management. The Genval workshop report. Gut 44:S1-S16
3. Fass R, Fennerty MB, Vakil N (2001) Nonerosive reflux disease: current concepts and dilemmas. Am J Gastroenterol 96:303-314
4. Fass R (2003) Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease. Am J Gastroenterol 98:S2-S7
5. Quigley EM (1997) Gastroesophageal reflux disease: spectrum or continuum? QJM 90:75-78
6. Adachi K, Hashimoto T, Hamamoto N, Hirakawa K, Niigaki M, Miyake T et al (2003) Symptom relief in patients with reflux esophagitis: comparative study of omeprazole, lansoprazole and rabeprazole. J Gastroenterol Hepatol 18:1392-1398
7. Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R (2003) Non-erosive reflux disease (NERD): acid reflux and symptom patterns. Aliment Pharmacol Ther 17:537-545
8. Dickman R, Bautista JM, Wong WM, Bhatt R, Beeler JN, Malagon I et al (2006) Comparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groups. Am J Gastroenterol 101:2463-2469
9. Silny J (1991) Intraluminal multiple impedance procedure for measurement of gastrointestinal motility. J Gastrointest Mot 3:151-162
10. Bredenoord AJ, Weusten BL, Sifrim D, Timmer R, Smout AJ (2005) Reproductivity of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol 100:265-269
11. Sifrim D, Castell D, Dent J, Kahrilas PJ (2004) Gastroesophageal reflux monitoring: review and consensus report on detention and definitions of acid, non-acid and gas reflux. Gut 53:1024-1031
12. Hila A, Agrawal A, Castell DO (2007) Combined multichannel intraluminal impedance testing compared to pH alone for diagnosing both acid and weakly acidic gastroesophageal reflux. Clin Gastroenterol Hepatol 5:172-177
13. Weusten BL, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ (1994) The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 107:1741-1745
14. Sifrim D, Silny J, Holloway RH, Janssens JJ (1999) Patterns of gas and liquid reflux during transient lower esophageal sphincter relaxation: a study using intraluminal electrical impedance. Gut 44:47-54
15. Frazzoni M, De Micheli E, Savarino V (2003) Different patterns of esophageal acid exposure distinguish complicated reflux disease from either erosive reflux esophagitis or non-erosive reflux disease. Aliment Pharmacol Ther 18:1091-1098
16. DeVault KR (2006) Review article: the role of acid suppression in patients with non-erosive reflux disease or functional heartburn. Aliment Pharmacol Ther 23 Suppl 1:33-9
17. Sifrim D, Holloway R, Silny J, Xin Z, Tack J, Lerut A et al (2001) Acid, non-acid and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings. Gastroenterology 120:1588-1598
18. Vela MF, Camacho-Lobato L, Srinivasan R, Tutuian R, Katz PO, Castell DO (2001) Simultaneous intraesophageal impedance and pH measurement of acid and non-acid gastroesophageal reflux: effect of omeprazole. Gastroenterology 120:1599-1606
19. Mainie I, Tutuian R, Shay S, Vela M, Zhang X, Sifrim D et al (2006) Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 55:1398-1402
20. Frazzoni M, De Micheli E, Zentilin P, Savarino V (2004) Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn. Aliment Pharmacol Ther 20:81-88
21. Cicala M, Emerenziani S, Caviglia R, Guarino MP, Vavassori P, Ribolsi M et al (2003) Intra-esophageal distribution and perception of acid reflux in patients with non-erosive gastroesophageal reflux disease. Aliment Pharmacol Ther 18:605-613
22. Niemantsverdriet EC, Timmer R, Breumelhof R (1997) Segmental acid sensitivity of the esophagus in patients with endoscopy-negative GERD. Gastroenterology 112:A237, (Abstract)
23. Fass R, Naliboff B, Higa L, Johnson C, Kodner A, Munakata J et al (1998) Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 115:1363-1373
24. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG (2000) Contribution of central sensitisation to the development of non-cardiac chest-pain. Lancet 356:1154-1159
25. Bredenoord AJ, Weusten BL, Timmer R, Smout AJ (2006) Characteristics of gastroesophageal reflux in symptomatic patients with and without excessive esophageal acid exposure. Am J Gastroenterol 101:2470-2475