Platelet gel supplementation in long bone nonunions treated by external fixation

Journal of Orthopaedic Trauma

Volumn 22, Issue 5, 2008, Pages 342-345

  Mariconda, Massimo ^a,b   Cozzolino, Francesco ^a   Cozzolino, Andrea ^a   D'Agostino, Elio ^a   Bove, Antonio ^a   Milano, Carlo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b FEDERICO II UNIVERSITY HOSPITAL   (Italy)

Author keywords

Growth factors; Long bone nonunions surgery; Platelet gel; Platelet rich plasma

Indexed keywords

ADULT; ARTICLE; CALLUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOREARM FRACTURE; FRACTURE EXTERNAL FIXATION; FRACTURE HEALING; HUMAN; HUMERUS FRACTURE; LONG BONE; MALE; PRIORITY JOURNAL; THROMBOCYTE; TIBIA FRACTURE;

ADULT; COHORT STUDIES; EXTERNAL FIXATORS; FEMALE; FOREARM INJURIES; FRACTURE FIXATION; FRACTURE HEALING; FRACTURES, UNUNITED; HUMANS; HUMERAL FRACTURES; MALE; MIDDLE AGED; PLATELET-RICH PLASMA; TIBIAL FRACTURES; TIME FACTORS; TREATMENT OUTCOME;

EID: 43049121740     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOT.0b013e318172cea5     Document Type: Article

References (33)

1. Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am. 2002;84:1032-1044.
2. Andrew JG, Hoyland JA, Freemont AJ, et al. Platelet-derived growth factor expression in normally healing human fractures. Bone. 1995;16: 455-460.
3. Gandhi A, Doumas C, O'Connor JP, et al. The effects of local platelet rich plasma delivery on diabetic fracture healing. Bone. 2006;38:540-546.
4. Marx RE. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg. 2004;62:489-496.
5. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endo. 1998;85:638-646.
6. Hee HT, Majd ME, Holt RT, et al. Do autologous growth factors enhance transforaminal lumbar interbody fusion? Eur Spine J. 2003;12:400-407.
7. Lowery GL, Kulkarni S, Pennisi AE. Use of autologous growth factors in lumbar spinal fusion. Bone. 1999;25:S47-50.
8. Weiner BK, Walker M. Efficacy of autologous growth factors in lumbar intertransverse fusions. Spine. 2003;28:1968-1970.
9. Rodriguez-Merchan EC, Forriol F. Nonunion: general principles and experimental data. Clin Orthop. 2004;419:4-12.
10. Hierholzer B, Sama B, Toro JB, et al. Plate fixation of ununited humeral shaft fractures: effect of type of bone graft on healing. J Bone Joint Surg Am. 2006;88:1442-1447.
11. Friedlander GE, Perry CR, Cole JD, et al. Osteogenic Protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions: A prospective, randomized clinical trial comparing rhOP-1 with fresh bone autograft. J Bone Joint Surg Am. 2001;83:S151-158.
12. Kloen P, Doty SB, Gordon E, et al. Expression and activation of the BMP-signaling components in human fracture nonunions. J Bone Joint Surg Am. 2002;84:1909-1918.
13. Resnick D, Goevgen T, Niwayama G. Diagnosis of bone joint disorders. Philadelphia: WB Saunders; 1988.
14. Soucacos PN, Dailiana Z, Beris AE, et al. Vascularised bone grafts for the management of non-union. Injury. 2006;37:S41-50.
15. Einhorn TA. The cell and molecular biology of fracture healing. Clin Orthop. 1998;355:S7-21.
16. Carlson ER. Bone grafting the jaws in the 21st century: The use of platelet-rich plasma and bone morphogenetic protein. Alpha Omegan. 2000;93:26-30.
17. Marx RE. Platelet-rich plasma (PRP): What is PRP and what is not PRP? Implant Dent. 2001;10:225-228.
18. Calori GM, D'Avino M, Tagliabue L, et al. An ongoing research for evaluation of treatment with BMPs or AGFs in long bone non-union: Protocol description and preliminary results. Injury. 2006;37:S43-50.
19. Tsay RC, Vo J, Burke A, et al. Differential growth factor retention by platelet-rich plasma composites. J Oral Maxillofac Surg. 2005;63: 521-528.
20. Einhorn TA, Majeska RJ, Mohaideen A, et al. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J Bone Joint Surg Am. 2003;85:1425-1435.
21. Hernigou P, Mathieu G, Poignard A, et al. Percutaneous autologous bone marrow grafting for nonunions. Surgical technique. J Bone Joint Surg Am. 2006;88:S322-327.
22. Zimmermann R, Arnold D, Strasser E, et al. Sample preparation technique and white cell content influence the detectable levels of growth factors in platelet concentrates. Vox Sang. 2003;85:283-289.
23. Kawase T, Okuda K, Saito Y, et al. Platelet-rich plasma provides nucleus for mineralization in cultures of partially differentiated periodontal ligament cells. In Vitro Cell Dev Biol Anim. 2005;41:171-176.
24. Pietramaggiori G, Kaipainen A, Czeczuga JM, et al. Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds. Wound Repair Regen. 2006;14:573-580.
25. Sum R, Hager S, Pietramaggiori G, et al. Wound-healing properties of trehalose-stabilized freeze-dried outdated platelets. Transfusion. 2007;47: 672-679.
26. Siebrecht MA, De Rooij PP, Arm DM, et al. Platelet concentrate increases bone ingrowth into porous hydroxyapatite. Orthopedics. 2002;25: 169-172.
27. Jensen TB, Rahbek O, Overgaard S, et al. No effect of platelet-rich plasma with frozen or processed bone allograft around noncemented implants. Int Orthop. 2005;29:67-72.
28. Ranly DM, McMillan J, Keller T, et al. Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice. J Bone Joint Surg Am. 2005;87:2052-2064.
29. Bibbo C, Bono CM, Lin SS. Union rates using autologous platelet concentrate alone and with bone graft in high-risk foot and ankle surgery patients. J Surg Orthop Adv. 2005;14:17-22.
30. Carreon LY, Glassman SD, Anekstein Y, et al. Platelet gel (AGF) fails to increase fusion rates in instrumented posterolateral fusions. Spine. 2005; 30:E243-246.
31. Roukis TS, Zgonis T, Tiernan B. Autologous platelet-rich plasma for wound and osseous healing: a review of the literature and commercially available products. Adv Ther. 2006;23:218-237.
32. Rai B, Oest ME, Dupont KM, et al. Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. J Biomed Mater Res A. 2007;81:888-899.
33. Lochner HV, Bhandari M, Tornetta P 3rd. Type-II error rates (beta errors) of randomized trials in orthopaedic trauma. J Bone Joint Surg Am. 2001; 83:1650-1655.