Autologous platelet-rich plasma for wound and osseous healing: A review of the literature and commercially available products

Advances in Therapy

Volumn 23, Issue 2, 2006, Pages 218-237

  Roukis, Thomas S ^a   Zgonis, Thomas ^b   Tiernan, Breck ^c,d  

^a MADIGAN ARMY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c DES MOINES UNIVERSITY   (United States)

^d Norwegian American Hospital   (United States)

Author keywords

Autologous platelet poor plasma; Autologous platelet rich plasma; Bone graft; Ulceration; Wound coverage

Indexed keywords

ANTICOAGULANT AGENT; BIOMATERIAL; CALCIUM CHLORIDE; CALCIUM PHOSPHATE; CITRATE CALCIUM; THROMBIN; TOPICAL BOVINE THROMBIN; UNCLASSIFIED DRUG;

AUTOLOGOUS THROMBOCYTE POOR PLASMA; AUTOLOGOUS THROMBOCYTE RICH PLASMA; BLOOD SAMPLING; BONE GRAFT; CELL SEPARATOR DEVICE; CLINICAL TRIAL; DEVICE; FRACTURE HEALING; HUMAN; IMPLANT; INTERMETHOD COMPARISON; MAXILLOFACIAL SURGERY; NONHUMAN; ORAL SURGERY; ORTHOPEDIC SURGERY; PLASTIC SURGERY; REVIEW; SOFT TISSUE INJURY; SPINE SURGERY; TECHNIQUE; THROMBOCYTE POOR PLASMA; THROMBOCYTE RICH PLASMA; THROMBOCYTOPHERESIS; VETERINARY MEDICINE; WOUND HEALING;

BLOOD PLATELETS; BLOOD TRANSFUSION, AUTOLOGOUS; BONE REGENERATION; HUMANS; PLATELET TRANSFUSION; WOUND HEALING;

EID: 33745033389     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02850128     Document Type: Review

References (55)

1. Behnke O, Forer A. From megakaryocytes to platelets: platelet morphogenesis takes place in the bloodstream. Eur J Haematol Suppl. 1998;61:3-23.
2. Diegelman RF, Evans MC. Wound healing: an overview of acute fibrotic and delayed healing. Front Biosci. 2004;9:283.
3. Pierce GF, Mustoe TA, Lingelbach J, et al. Platelet-derived growth factor and transforming growth factor-β enhance tissue repair by unique mechanisms. J Cell Biol 1989;109:429-440.
4. Pierce GF, Mustoe TA, Altrock BW, et al. Role of platelet-derived growth factor in wound healing. J Cell Biochem. 1991;45:319-326.
5. Pfeilschifter J, Öechsner M, Naumann A, et al. Stimulation of bone matrix apposition in vitro by local growth factors: a comparison between insulin-like growth factor-1, platelet derived growth factor, and transforming growth factor beta. Endocrinology. 1990;127:69-75.
6. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114:1502-1508.
7. Lowery GL, Kulkarni S, Pennisi AE. Use of autologous growth factors in lumbar spinal surgery. Bone. 1999;25:47S-50S.
8. Kevy S, Jacobson M. Comparison of methods for point of care preparation of autologous platelet gel. J Extra Corpor Technol. 2004;36:28-35.
9. Dennis JE, Haynesworth SE, Young RG, et al. Osteogenesis in marrow-derived mesenchymal cell porous ceramic composites transplanted subcutaneously: effect of fibronectin and laminin on cell retention and rate of osteogenic expression. Cell Transplant. 1992;1:23-32.
10. Blokhuis TJ, Termaat MF, Den Boer FC, et al. Properties of calcium phosphate ceramics in relation to their in vivo behavior. J Trauma. 2000;48:179-186.
11. Bhanot S, Alex JC. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg. 2002;18:27-33.
12. Kirsner RS, Eaglstein WH. The wound healing process. Dermatol Clin. 1993;11:629-640.
13. Duff R, Newman D. The correlation of chronic wound healing to growth factor levels in platelet extracts. Presented at: 3rd International Symposium on Tissue Repair; January 10-14, 1990; Miami, Fla.
14. Carter CA, Jolly DG, Worden CE, et al. Platelet-rich plasma promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol. 2003;74:244-255.
15. Man D, Plosker H, Winland-Brown JE, et al. The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plast Reconstr Surg. 2001;107:229-237.
16. Welsh WJ. Autologous platelet gel: clinical function and usage in plastic surgery. Cosmet Dermatol. 2000;13:13-18.
17. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62:489-496.
18. Doucette MM, Fylling C, Knighton DR. Amputation prevention in a high-risk population through a comprehensive wound-healing protocol. Arch Phys Med Rehabil. 1989;70:780-785.
19. Knighton DR, Fylling CP, Doucette MM. Wound healing and amputation in a high-risk diabetic population. Wounds. 1989;2:107-114.
20. Knighton DR, Fylling CP, Fiegel VD, Cerra F. Amputation prevention in an independently reviewed at-risk diabetic population using a comprehensive wound care protocol. Am J Surg. 1990;160:466-471.
21. Glover JL, Weingarten MS, Buchbinder DS, Poucher RL, Deitrick GA 3rd, Fylling CP. A 4-year outcome-based retrospective study of wound healing and limb salvage in patients with chronic wounds. Adv Wound Care. 1997;10:33-38.
22. Fylling CP, Mc Keown PC. Cost and healing efficacy of treating diabetic foot ulcers in a comprehensive wound management program with growth factor technology. Diabetes. 1990;39:18S.
23. Bentkover JD, Champion AH. Economic evaluation of alternative methods of treatment for diabetic foot ulcer patients: cost effectiveness of platelet releasate and wound care clinics. Wounds. 1993;5:207-215.
24. Knighton DR, Ciresi KF, Fiegel VD, et al. Classification and treatment of chronic nonhealing wounds: successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986;204:322-330.
25. Atri SC, Misra J, Bisht D, et al. Use of homologous platelet factors in achieving total healing of recalcitrant skin ulcers. Surgery. 1990;108:508-512.
26. Knighton DR, Ciresi K, Fiegel VD, et al. Stimulation of repair in chronic non-healing cutaneous ulcers: a prospective randomized blinded trial using platelet-derived wound healing formula. Surg Gynecol Obstet. 1990;170:56-60.
27. Steed DL, Goslen JB, Holloway GA, et al. Randomized, double blind trial in healing of chronic diabetic foot ulcers: CT-102 activated platelet supernatant, topical versus placebo. Diabetes Care. 1992;15:1598-1604.
28. Holloway GA, Steed DL, Demarco MJ, et al. A randomized, controlled dose response trial of activated platelet supernatant, topical CT-102 in chronic, non-healing diabetic wounds. Wounds. 1993;5:160-168.
29. Crovetti G, Martinelli G, Issi M, et al. Platelet gel for healing chronic wounds. Transfus Apheresis Sci. 2004;30:145-151.
30. Slater M, Patava J, Kingham K, et al. Involvement of platelets in stimulating osteogenic activity. J Orthop Res. 1995;13:655-663.
31. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638-646.
32. Dugrillon A, Eichler H, Kern S, et al. Autologous concentrated platelet-rich plasma (CPRP) for local application in bone regeneration. Int J Oral Maxillofac Surg. 2002;31:615-619.
33. Weibrich G, Kleis WK, Hafner G, et al. Comparison of platelet, leukocyte, and growth factor levels in point-of-care platelet-enriched plasma, prepared using a modified curasan kit, with preparations received from a local blood bank. Clin Oral Implants Res. 2003;14:357-362.
34. Choi BH, Im CJ, Huh JY, et al. Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. Int J Oral Maxillofac Surg. 2004;33:56-59.
35. Soffer E, Ouhayoun JP, Dosquet C, et al. Effects of platelet lysates on select bone cell functions. Clin Oral Implants Res. 2004;15:581-588.
36. Luboshitz J, Berger U, Yaari O, et al. Platelet rich plasma (PRP) as an adjuvant tool for bone augmentation. Refuat Hapeh Vehashinayim. 2004;21:63-70,103.
37. Yazawa M, Ogata H, Kimura A, et al. Basic studies on bone formation ability by platelet rich plasma in rabbits. J Craniofac Surg. 2004;15:439-446.
38. Siebrecht MA, De Rooij PP, Arm DM, et al. Platelet concentrate increases bone ingrowth into porous hydroxyapatite. Orthopedics. 2002;25:169-172.
39. Fennis JP, Stoelinga PJ, Jansen JA. Mandibular reconstruction: a clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasma. Int J Oral Maxillofac Surg. 2002;31:281-286.
40. Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study. J Oral Maxillofac Surg. 2002;60:1176-1181.
41. Luo QF, Wang X, Wang XX, et al. The effect of platelet-rich plasma on distraction osteogenesis. Zhonghua Zheng Xing Wai Ke Za Zhi. 2004;20:376-379.
42. Robiony M, Polini F, Costa F, et al. Osteogenesis distraction and platelet-rich plasma for bone restoration of the severely atrophic mandible: preliminary results. J Oral Maxillofac Surg. 2002;60:630-635.
43. Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis: a preliminary result of three cases. Bone. 2004;35:892-898.
44. Fontana S, Olmedo DG, Linares JA, et al. Effect of platelet-rich plasma on the peri-implant bone response: an experimental study. Implant Dent. 2004;13:73-78.
45. Zechner W, Tangl S, Tepper G, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18:15-22.
46. Kim SG, Kim WK, Pack JC, et al. A comparative study of osseointegration of avana implants in demineralized freeze-dried bone alone or with platelet-rich plasma. J Oral Maxillofac Surg. 2002;60:1018-1025.
47. Kassolis JD, Rosen PS, Reynolds MA. Alveolar ridge and sinus augmentation utilizing platelet rich plasma in combination with freeze-dried bone allograft: case series. J Periodontol. 2000;71:1654-1661.
48. Jakse N, Tangl S, Gilli R, et al. Influence of platelet rich plasma on autogenous sinus grafts: an experimental study on sheep. Clin Oral Implant Res. 2003;14:578-583.
49. Butterfield KJ, Bennett J, Gronowicz G, et al. Effect of platelet-rich plasma with autogenous bone grafts for sinus augmentation in a rabbit model. J Oral Maxillofac Surg. 2005;63:370-376.
50. Rodriguez A, Anastassov GE, Lee H, et al. Maxillary sinus augmentation with deproteinated bovine bone and platelet rich plasma with simultaneous insertion of endosseous implants. J Oral Maxillofac Surg. 2003;61:157-163.
51. Maiorana C, Sommariva L, Brivio P, et al. Maxillary sinus augmentation with an organic bovine bone (Bio-Oss) and autologous platelet-rich plasma: preliminary clinical and histologic evaluations. Int J Periodont Restor Dent. 2003;23:227-235.
52. Wiltfang J, Schlegel KA, Schultze-Mosgau S, et al. Sinus floor augmentation with β-tricalcium-phosphate (β-TCP): does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Implant Res. 2003;14:213-218.
53. Sweeney JD, Holme S, Heaton A. Quality of platelet concentrates. Immunol Invest. 1995;24:353-370.
54. Weibrich G, Kleis WK, Hafner G, et al. Growth factor level in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Craniomaxillofac Surg. 2002;30:97-102.
55. Waters JH, Roberts KC. Database review of possible factors influencing point-of-care platelet gel manufacture. J Extra Corpor Technol. 2004;36:250-254.