Dramatic reduction of erythrocyte glucose-6-phosphate dehydrogenase activity in athletes participating in the ultradistance foot race "Spartathlon"

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 3, 2008, Pages 228-232

  Schulpis, K H ^a   Tsironi, M ^b   Skenderi, K ^c   Lazaropoulou, C ^d   Parthimos, N ^e   Reclos, G ^f   Goussetis, E ^d   Tsakiris, S ^e   Papassotiriou, I ^d  

^a Institute of Child Health   (Greece)

^b UNIVERSITY OF PELOPONNESE   (Greece)

^c HAROKOPIO UNIVERSITY   (Greece)

^d AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^e UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^f R and D Diagnostics   (Greece)

Author keywords

Exercise; G6PD; Glutathione; NADP NADPH; Oxidation

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; HEXOSE PHOSPHATE; MALONALDEHYDE; OXIDE;

ADULT; ANALYZER; ANTIOXIDANT ACTIVITY; ARTICLE; ATHLETE; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CHEMICAL ANALYSIS; CLINICAL CHEMISTRY; CONTROLLED STUDY; ENDURANCE SPORT; ENZYME ACTIVITY; ENZYME REGULATION; ERYTHROCYTE; EXERCISE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REDUCTION; RUNNING;

ADULT; ATHLETIC PERFORMANCE; ERYTHROCYTES; GLUCOSEPHOSPHATE DEHYDROGENASE; HUMANS; LIPID PEROXIDATION; MALE; MIDDLE AGED; PHYSICAL ENDURANCE; RUNNING;

ELAGATIS;

EID: 43049119972     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510701604610     Document Type: Article

References (20)

1. Luzzatto L, Mehta A, Vulliami T. Glucose-6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill. 2000. p. 4517-4553.
2. Kirkman HN, Gaetani CD, Clemons EH, Mareni C. Red cell NADP and NADPH in Glucose-6-Phosphate Dehydrogenase deficiency. J Clin Invest 1975;55:875-8.
3. Schulpis KH, Reclos GJ, Parthimos T, Parthimos N, Gavriilidis A, Tsakiris S. L-cysteine supplementation protects the erythrocyte clusose-6-phosphate dehydrogenase activity from reduction induced by forced training. Clin Biochem 2006;39:1002-6.
4. Tsakiris S, Reclos GJ, Parthimos T, Parthimos N, Tsakiris T, Schulpis KH. alpha-tocopherol supplementation restores the reduction of erythrocyte glucose-6-phosphate dehydrogenase activity induced by forced training. Pharmacol Res 2006;54:373-9.
5. C. Pitsavos, D. Panagiotakos, N. Tzima, C. Chrysohoou, M. Economou, A. Zampelas, C. Stefanadis. Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Am J Clin Nutr 2005;82:694-699.
6. Kondo T. Impaired glutathione metabolism in hemolytic anemia. Rinsho Byori 1990;38:355-9.
7. Child RB, Wilkinson DM, Fallowfield JL, Donnelly AE. Elevated serum antioxidant capacity and plasma malondialdehyde concentration in response to a simulated half-marathon run. Med Sci Sports Exerc 1998;30:1603-7.
8. Reclos GJ, Hatzidakis CJ, Schulpis KH. Glucose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficiency female neonates are missed during routine screening. J Med Screen 2000;7:46-51.
9. Nikolaidis M, Jamurtas A, Paschalis V, Kostaropoulos I, Kladi-Skandali A, Balamitsi V, Koutedakis Y, Kouretas D. Exercise-Induced Oxidative Stress in G6PD-Deficient Individuals. Med Sci Sports Exerc 2006;38:1443-1450.
10. Jamurtas A, Fatouros J, Koukosias N, Manthou E, Tofas T, Yfanti C, Nikolaidis M, Koutedakis Y. Effect of exercise on oxidative stress in individuals with glucose-6-phosphate dehydrogenase deficiency. In Vivo 2006;20:875-80.
11. Y. Michailidis, A. Jamurtas, M. Nikolaidis, I. Fatouros, Y. Koutedakis, I. Papassotiriou, D. Kouretas. Sampling time is crucial for measurement of aerobic exercise-induced oxidative stress. Med Scin Spor Exerc 2007;39:1107-1113.
12. Chevion S, Moran DS, Heled Y, Shani Y, Regev G, Abbou B, Berenshtein E, Stadtman ER, Epstein Y. Plasma antioxidant status and cell injury after severe physical exercise. Proc Natl Acad Sci U S A 2003;100:5119-23.
13. Das SK, Hinds JE, Hardy RE, Collins JC, Mukherjce S. Effects of physical stress on peroxide scavengers in normal and sickle cell treait erythrocytes. Free Radic Biol Med 1993;14:139-47.
14. Fallon KE, Sivyer G, Sivyer K, Dare A. The biochemistry of runners in a 1600 km ultramarathon. Br J Sports Med 1999;33:264-9.
15. Pialoux V, Mounier R, Ponsot E, Rock E, Mazur A, Dufour S, Richard R, Richalet JP, Coudert J, Fellmann N. Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. Eur J Clin Nutr 2006;60:1345-54.
16. Fukuratari T, Shibata K, Ishihara K, Fushiki T, Sugimoto E. Elevation of blood NAD level after moderate exercise in young women and mice. J Nutr Sci Vitaminol 2001;47:177-9.
17. Prfybytkowski E, Averil-Bates DA. Correlation between glutathione and stimulation of the pentose phosphate cycle inc situ Chinese hamster ovary cells exposed to hydrogen peroxide. Arch Biochem Biophys 1996;326:91-8.
18. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.
19. Sastre J, Asen si M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J. Exhausive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration. Am J Physiol 1992;263:R992-5.
20. Mariotti F, Simbelie KL, Makarios-Lahham L, Huneau JF, Laplaize B, Tome D, Even PC. Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr 2004;134:128-31.