Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infants

Jornal de Pediatria

Volumn 84, Issue 2, 2008, Pages 141-146

  Aycicek, Ali ^a   Kocyigit, Abdurrahim ^a   Erel, Ozcan ^a   Senturk, Hakan ^b  

^a HARRAN UNIVERSITY   (Turkey)

^b Children's Hospital at Sanliurfa   (Turkey)

Author keywords

Comet assay; DNA damage; Hyperbilirubinemia; Oxidative stress; Phototherapy

Indexed keywords

ANTIOXIDANT; BILIRUBIN; DNA; OXIDIZING AGENT;

ARTICLE; BILIRUBIN BLOOD LEVEL; CHILD CARE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; NEWBORN; NEWBORN JAUNDICE; OXIDATIVE STRESS; PHOTOTHERAPY; SCORING SYSTEM;

CASE-CONTROL STUDIES; COMET ASSAY; DNA DAMAGE; FEMALE; HUMANS; INFANT, NEWBORN; JAUNDICE, NEONATAL; LEUKOCYTES, MONONUCLEAR; MALE; OXIDATIVE STRESS; PHOTOTHERAPY; TIME FACTORS;

EID: 43049106864     PISSN: 00217557     EISSN: None     Source Type: Journal    
DOI: 10.2223/JPED.1765     Document Type: Article

References (33)

1. Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002;65:599-606.
2. Tan KL. Phototherapy for neonatal jaundice. Acta Paediatr. 1996;85:277-9.
3. Lamola AA, Blumberg WE, McClead R, Fanaroff A. Photoisomerized bilirubin in blood from infants receiving phototherapy. Proc Natl Acad Sci U S A. 1981;78:1882-6.
4. Babara JS, Robert MK. Jaundice and hyperbilirubinemia in the newborn. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics. 17th ed. Philadelphia, PA: Saunders; 2004. p. 592 7.
5. Brennan ML, Wu W, Fu X, Shen Z, Song W, Frost H, et al. A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. J Biol Chem. 2002;277:17415-27.
6. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 2004;266:37-56.
7. Gathwala G, Sharma S. Oxidative stress, phototherapy and the neonate. Indian J Pediatr. 2000;67:805-8.
8. Turgut M, Basaran O, Cekmen M, Karatas F, Kurt A, Aygun AD. Oxidant and antioxidant levels in preterm newborns with idiopathic hyperbilirubinaemia. J Paediatr Child Health. 2004;40:633-7.
9. Akisu M, Yilmaz D, Tuzun S, Kultursay N. Antioxidant defense systems in newborns undergoing phototherapy. Indian J Pediatr. 1999;66:651-5.
10. McDonagh AF. The role of singlet oxygen in bilirubin photo-oxidation. Biochem Biophys Res Commun. 1971;44:1306-11.
11. Aycicek A, Erel O. Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy. J Pediatr (Rio J). 2007;83:319-22.
12. Newman TB, Maisels MJ. Evaluation and treatment of jaundice in the term newborn: A kinder, gentler approach. Pediatrics. 1992;89:809-18.
13. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988;175:184-91.
14. Kocyigit A, Keles H, Selek S, Guzel S, Celik H, Erel O. Increased DNA damage and oxidative stress in patients with cutaneous leishmaniasis. Mutat Res. 2005;585:71-8.
15. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37:277-85.
16. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38:1103-11.
17. Aycicek A, Erel O, Kocyigit A. Increased oxidative stress in infants exposed to passive smoking. Eur J Pediatr. 2005;164:775-8.
18. Harma M, Harma M, Erel O. Oxidative stress in women with preeclampsia. Am J Obstet Gynecol. 2005;192:656-7.
19. Cole J, Skopek TR. International Commission for Protection Against Environmental Mutagens and Carcinogens. Working paper no. 3. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutat Res. 1994;304:33-105.
20. Moller P, Knudsen LE, Loft S, Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev. 2000;9:1005-15.
21. Garcia O, Mandina T, Lamadrid AI, Diaz A, Remigio A, Gonzalez Y, et al. Sensitivity and variability of visual scoring in the comet assay. Results of an inter-laboratory scoring exercise with the use of silver staining. Mutat Res. 2004;556:25-34.
22. Rojas E, Lopez MC, Valverde M. Single cell gel electrophoresis assay: methodology and applications. J Chromotogr B Biomed Sci Appl. 1999;722:225-54.
23. Sparrow JR, Zhou J, Cai B. DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination. Invest Ophthalmol Vis Sci. 2003;44:2245-51.
24. Arlett CF, Lowe JE, Harcourt SA, Waugh AP, Cole J, Roza L, et al. Hypersensitivity of human lymphocytes to UV-B and solar irradiation. Cancer Res. 1993;53:609-14.
25. Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol. 2004;195:298-308.
26. Tornaletti S, Pfeifer GP. UV damage and repair mechanisms in mammalian cells. Bioessays 1996;18:221-8.
27. Meulemans CC, Werner M. Skin penetration depth optical radiation. http://www.solarcsystems.com/pdfs/philips_light_sources_for_phototherapy.pdf. Access: 19/9/2007.
28. Warner BB, Wispe JR Free radical mediated diseases in pediatrics. Semin Perinatol. 1992;16:47-57.
29. Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet. 1994;344:721-4.
30. Stocker R, Ames BN. Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc Natl Acad Sci USA. 1987; 84:8130-4.
31. Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin bound bilirubin. Proc Natl Acad Sci USA. 1987;84:5918-22.
32. Bohles H, Schnall B. The effect of phototherapy on serum uric acid. Klin Padiatr. 1981;193:308-10.
33. Tan KL. Phototherapy for neonatal jaundice. Clin Perinatol. 1991;18:423-39.