메뉴 건너뛰기




Volumn 51, Issue 8, 2008, Pages 2580-2584

Isoxazolone based inhibitors of p38 MAP kinases

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 3 (PYRIDIN 4YL) 2 TOSYLISOXAZOL 5 (2H) ONE; 4 [3 (4 FLUOROPHENYL) 5 METHOXYISOXAZOL 4 YL]PYRIDINE; 5 ALKOXYISOXAZOLE; 5 ISOXAZOLONE; IMIDAZOLE; ISOXAZOLE DERIVATIVE; ISOXAZOLONE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N ETHYL 4 (4 FLUOROPHENYL) 5 OXO 3 (PYRIDIN 4 YL)ISOXAZOLE;

EID: 43049090109     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701343f     Document Type: Article
Times cited : (37)

References (22)
  • 1
    • 0033965158 scopus 로고    scopus 로고
    • The p38 signal transduction pathway. Activation and function
    • Ono, K.; Han, J. The p38 signal transduction pathway. Activation and function. Cell. Signalling 2000, 12, 1-13.
    • (2000) Cell. Signalling , vol.12 , pp. 1-13
    • Ono, K.1    Han, J.2
  • 3
    • 9744265656 scopus 로고    scopus 로고
    • Tetrasubstituted imidazole inhibitors of cytokine release: Probing substituents in the N-1 position
    • Laufer, S. A.; Zimmermann, W.; Ruff, K. J. Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position. J. Med. Chem. 2004, 47, 6311-6325.
    • (2004) J. Med. Chem , vol.47 , pp. 6311-6325
    • Laufer, S.A.1    Zimmermann, W.2    Ruff, K.J.3
  • 4
    • 0037057579 scopus 로고    scopus 로고
    • Imidazole inhibitors of cytokine release: Probing substituents in the 2 position
    • Laufer, S. A.; Striegel, H. G.; Wagner, G. K. Imidazole inhibitors of cytokine release: probing substituents in the 2 position. J. Med. Chem. 2002, 45, 4695-1705.
    • (2002) J. Med. Chem , vol.45 , pp. 4695-1705
    • Laufer, S.A.1    Striegel, H.G.2    Wagner, G.K.3
  • 5
    • 43049113269 scopus 로고    scopus 로고
    • Laufer, S.; Striegel, H.-G.; Tollmann, K.; Albrecht, W. Preparation of 2-Methylsulfanyl-3H-imidazoles and Related Compounds as Immunomodulators. 2002-10238045[10238045]. 31; DE. 20-8-2002. 2004; Merckle G.m.b.H.Chem.-Pharm. Fabrik.Germany.
    • Laufer, S.; Striegel, H.-G.; Tollmann, K.; Albrecht, W. Preparation of 2-Methylsulfanyl-3H-imidazoles and Related Compounds as Immunomodulators. 2002-10238045[10238045]. 31; DE. 20-8-2002. 2004; Merckle G.m.b.H.Chem.-Pharm. Fabrik.Germany.
  • 7
    • 33646475722 scopus 로고    scopus 로고
    • Substituted isoxazoles as potent inhibitors of p38 MAP kinase
    • Laufer, S. A.; Margutti, S.; Fritz, M. D. Substituted isoxazoles as potent inhibitors of p38 MAP kinase. ChemMedChem 2006, 1, 197-207.
    • (2006) ChemMedChem , vol.1 , pp. 197-207
    • Laufer, S.A.1    Margutti, S.2    Fritz, M.D.3
  • 8
    • 43049121111 scopus 로고    scopus 로고
    • Clark, M. P.; Djung, J. F.-J.; Laughlin, S. K.; Tullis, J. S.; Naichus, M. G.; De, B. Isoxazolones Useful in Treating Discuses Associated with Unwanted Cytokine Activity. 2002-US15431[2002094266], 69: WO 15-5-2002, 2002: The Procter & Gamble Company.
    • Clark, M. P.; Djung, J. F.-J.; Laughlin, S. K.; Tullis, J. S.; Naichus, M. G.; De, B. Isoxazolones Useful in Treating Discuses Associated with Unwanted Cytokine Activity. 2002-US15431[2002094266], 69: WO 15-5-2002, 2002: The Procter & Gamble Company.
  • 10
    • 0010308298 scopus 로고
    • A new synthesis of 3.4-diaryl-5-oxo-4,5-dihydroisoxazoles and their transformation to 5-[N-(w-aminoalkyl)amino]isoxazoles and 5-(2-aminoethylthio)isoxazoles
    • Dannhardt, G.; Laufer, S.; Obergrusberger, I. A new synthesis of 3.4-diaryl-5-oxo-4,5-dihydroisoxazoles and their transformation to 5-[N-(w-aminoalkyl)amino]isoxazoles and 5-(2-aminoethylthio)isoxazoles. Synthesis 1989, 27, 5-280.
    • (1989) Synthesis , vol.27 , pp. 5-280
    • Dannhardt, G.1    Laufer, S.2    Obergrusberger, I.3
  • 13
    • 0000660698 scopus 로고
    • Mechanisms of heterocyclic ring formations. 4. A carbon-13 NMR study of the reaction of b-keto esters with hvdroxylamine
    • Katritzky, A. R.; Barezynski, P.; Ostercamp, D. L.; Yousaf, T. I. Mechanisms of heterocyclic ring formations. 4. A carbon-13 NMR study of the reaction of b-keto esters with hvdroxylamine. J. Org. Chem. 1986, 51, 4037-4042.
    • (1986) J. Org. Chem , vol.51 , pp. 4037-4042
    • Katritzky, A.R.1    Barezynski, P.2    Ostercamp, D.L.3    Yousaf, T.I.4
  • 14
    • 0001873191 scopus 로고
    • Tautomerism of heteroaromatic compounds with five-membered rings. I. 5-Hydroxyisoxazoles-5-isoxaxolones
    • Boulton, A. J.; Katritzky, A. R. Tautomerism of heteroaromatic compounds with five-membered rings. I. 5-Hydroxyisoxazoles-5-isoxaxolones. Tetrahedron 1961, 12, 41-50.
    • (1961) Tetrahedron , vol.12 , pp. 41-50
    • Boulton, A.J.1    Katritzky, A.R.2
  • 15
    • 43049120397 scopus 로고    scopus 로고
    • Franchini, P. F. Dipole moments and tautomerism of isoxazolin-5-ones. Corsie Semin. Chim. 1968, 14, 23-25.
    • Franchini, P. F. Dipole moments and tautomerism of isoxazolin-5-ones. Corsie Semin. Chim. 1968, 14, 23-25.
  • 16
    • 43049148102 scopus 로고
    • Dipole moments of 5-substituted isoxazoles. 1. Dipole moments and tautomerism of isoxazolin-5-ones
    • Cencioni, R.; Franchini, P. F.; Orienti, M. Dipole moments of 5-substituted isoxazoles. 1. Dipole moments and tautomerism of isoxazolin-5-ones. Tetrahedron 1968, 24, 151-166.
    • (1968) Tetrahedron , vol.24 , pp. 151-166
    • Cencioni, R.1    Franchini, P.F.2    Orienti, M.3
  • 17
    • 43049087872 scopus 로고
    • Azoles. LXXII. Unequivocal synthesis and tautomerism of 3-isoxazolones
    • Jacquier, R.; Petrus, C.; Petrus, F.; Verducci, J. Azoles. LXXII. Unequivocal synthesis and tautomerism of 3-isoxazolones. Bull. Soc. Chim. Fr. 1970, 197, 8-1985.
    • (1970) Bull. Soc. Chim. Fr , vol.197 , pp. 8-1985
    • Jacquier, R.1    Petrus, C.2    Petrus, F.3    Verducci, J.4
  • 19
    • 0008752661 scopus 로고    scopus 로고
    • Chan, A. W. K.; Crow, W. D.; Gosney, I. Isothiazole chemistry. X. Acylation, alkylation, and tautomerism in 3-hydroxyisothiazole. Tetrahedron 1970, 26, 2497-2506.
    • Chan, A. W. K.; Crow, W. D.; Gosney, I. Isothiazole chemistry. X. Acylation, alkylation, and tautomerism in 3-hydroxyisothiazole. Tetrahedron 1970, 26, 2497-2506.
  • 20
    • 27644589566 scopus 로고    scopus 로고
    • An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays
    • Laufer, S.; Thuma, S.; Peifer, C.: Greim, C.; Herweh, Y.; Albrecht, A.; Dehner, F. An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays. Anal. Biochem. 2005, 344, 135-137.
    • (2005) Anal. Biochem , vol.344 , pp. 135-137
    • Laufer, S.1    Thuma, S.2    Peifer, C.3    Greim, C.4    Herweh, Y.5    Albrecht, A.6    Dehner, F.7
  • 21
    • 0000826617 scopus 로고    scopus 로고
    • Hydrogen bonding properties of oxygen and nitrogen acceptors in aromatic heterocycles
    • Nobeli, I.; Price, S. L.; Lommerse, J. P. M.; Taylor, R. Hydrogen bonding properties of oxygen and nitrogen acceptors in aromatic heterocycles. J. Comput. Chem. 1997, 18, 2060-2074.
    • (1997) J. Comput. Chem , vol.18 , pp. 2060-2074
    • Nobeli, I.1    Price, S.L.2    Lommerse, J.P.M.3    Taylor, R.4
  • 22
    • 0011639217 scopus 로고    scopus 로고
    • Oxygen and nitrogen in competitive situations: Which is the hydrogen-bond acceptor?
    • Boehm, H. J.; Brode, S.; Hesse, U.; Klebe, G. Oxygen and nitrogen in competitive situations: which is the hydrogen-bond acceptor? Chem.-Eur. J. 1996, 2, 1509-1513.
    • (1996) Chem.-Eur. J , vol.2 , pp. 1509-1513
    • Boehm, H.J.1    Brode, S.2    Hesse, U.3    Klebe, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.