-
1
-
-
0033965158
-
The p38 signal transduction pathway. Activation and function
-
Ono, K.; Han, J. The p38 signal transduction pathway. Activation and function. Cell. Signalling 2000, 12, 1-13.
-
(2000)
Cell. Signalling
, vol.12
, pp. 1-13
-
-
Ono, K.1
Han, J.2
-
2
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J. C.; Uydon, J. T.; McDonnell, P. C.; Gallagher, T. F.; Kumar, S.; Green, D.; McNulty, D.; Blumenthal, M. J.; Heyes, J. R. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372, 739-746.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Uydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heyes, J.R.9
-
3
-
-
9744265656
-
Tetrasubstituted imidazole inhibitors of cytokine release: Probing substituents in the N-1 position
-
Laufer, S. A.; Zimmermann, W.; Ruff, K. J. Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position. J. Med. Chem. 2004, 47, 6311-6325.
-
(2004)
J. Med. Chem
, vol.47
, pp. 6311-6325
-
-
Laufer, S.A.1
Zimmermann, W.2
Ruff, K.J.3
-
4
-
-
0037057579
-
Imidazole inhibitors of cytokine release: Probing substituents in the 2 position
-
Laufer, S. A.; Striegel, H. G.; Wagner, G. K. Imidazole inhibitors of cytokine release: probing substituents in the 2 position. J. Med. Chem. 2002, 45, 4695-1705.
-
(2002)
J. Med. Chem
, vol.45
, pp. 4695-1705
-
-
Laufer, S.A.1
Striegel, H.G.2
Wagner, G.K.3
-
5
-
-
43049113269
-
-
Laufer, S.; Striegel, H.-G.; Tollmann, K.; Albrecht, W. Preparation of 2-Methylsulfanyl-3H-imidazoles and Related Compounds as Immunomodulators. 2002-10238045[10238045]. 31; DE. 20-8-2002. 2004; Merckle G.m.b.H.Chem.-Pharm. Fabrik.Germany.
-
Laufer, S.; Striegel, H.-G.; Tollmann, K.; Albrecht, W. Preparation of 2-Methylsulfanyl-3H-imidazoles and Related Compounds as Immunomodulators. 2002-10238045[10238045]. 31; DE. 20-8-2002. 2004; Merckle G.m.b.H.Chem.-Pharm. Fabrik.Germany.
-
-
-
-
6
-
-
0032541986
-
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes
-
Adams, J. L.; Boehm, J. C.; Kassis, S.; Goryeki, P. D.; Webb, E. F.; Hall, R.; Sorenson, M.; Lee, J. C.; Ayrton, A.; Griswold, D. E.; Gallagher, T. F. Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. Bioorg. Med. Chem. Lett. 1998, 8, 3111-3116.
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, pp. 3111-3116
-
-
Adams, J.L.1
Boehm, J.C.2
Kassis, S.3
Goryeki, P.D.4
Webb, E.F.5
Hall, R.6
Sorenson, M.7
Lee, J.C.8
Ayrton, A.9
Griswold, D.E.10
Gallagher, T.F.11
-
7
-
-
33646475722
-
Substituted isoxazoles as potent inhibitors of p38 MAP kinase
-
Laufer, S. A.; Margutti, S.; Fritz, M. D. Substituted isoxazoles as potent inhibitors of p38 MAP kinase. ChemMedChem 2006, 1, 197-207.
-
(2006)
ChemMedChem
, vol.1
, pp. 197-207
-
-
Laufer, S.A.1
Margutti, S.2
Fritz, M.D.3
-
8
-
-
43049121111
-
-
Clark, M. P.; Djung, J. F.-J.; Laughlin, S. K.; Tullis, J. S.; Naichus, M. G.; De, B. Isoxazolones Useful in Treating Discuses Associated with Unwanted Cytokine Activity. 2002-US15431[2002094266], 69: WO 15-5-2002, 2002: The Procter & Gamble Company.
-
Clark, M. P.; Djung, J. F.-J.; Laughlin, S. K.; Tullis, J. S.; Naichus, M. G.; De, B. Isoxazolones Useful in Treating Discuses Associated with Unwanted Cytokine Activity. 2002-US15431[2002094266], 69: WO 15-5-2002, 2002: The Procter & Gamble Company.
-
-
-
-
9
-
-
20244380323
-
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production
-
Laughlin, S. K.; Clark, M. P.; Djung, J. F.; Golebiowski, A.; Brugel, T. A.; Sabat, M.; Bookland, R. G.; Laufersweiler, M. J.; VanRens, J. C.; Townes, J. A.; De, B.; Hsieh, L. C.; Xu, S. C.; Walter, R. L.; Mekel, M. J.; Janusz, M. J. The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production. Bioorg. Med. Chem. Lett. 2005, 15, 2399-2403.
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 2399-2403
-
-
Laughlin, S.K.1
Clark, M.P.2
Djung, J.F.3
Golebiowski, A.4
Brugel, T.A.5
Sabat, M.6
Bookland, R.G.7
Laufersweiler, M.J.8
VanRens, J.C.9
Townes, J.A.10
De, B.11
Hsieh, L.C.12
Xu, S.C.13
Walter, R.L.14
Mekel, M.J.15
Janusz, M.J.16
-
10
-
-
0010308298
-
A new synthesis of 3.4-diaryl-5-oxo-4,5-dihydroisoxazoles and their transformation to 5-[N-(w-aminoalkyl)amino]isoxazoles and 5-(2-aminoethylthio)isoxazoles
-
Dannhardt, G.; Laufer, S.; Obergrusberger, I. A new synthesis of 3.4-diaryl-5-oxo-4,5-dihydroisoxazoles and their transformation to 5-[N-(w-aminoalkyl)amino]isoxazoles and 5-(2-aminoethylthio)isoxazoles. Synthesis 1989, 27, 5-280.
-
(1989)
Synthesis
, vol.27
, pp. 5-280
-
-
Dannhardt, G.1
Laufer, S.2
Obergrusberger, I.3
-
11
-
-
0003536817
-
-
Elguero, J, Marzin, C, Katritzky, A. R, Linda, P, Eds, Academic Press: New York
-
Elguero, J., Marzin, C., Katritzky, A. R., Linda, P., Eds. Advances in Heterocyclic Chemistry, Supplement I: The Tautomerism of Hetemcycles: Academic Press: New York, 1976; p 656.
-
(1976)
Advances in Heterocyclic Chemistry, Supplement I: The Tautomerism of Hetemcycles
, pp. 656
-
-
-
13
-
-
0000660698
-
Mechanisms of heterocyclic ring formations. 4. A carbon-13 NMR study of the reaction of b-keto esters with hvdroxylamine
-
Katritzky, A. R.; Barezynski, P.; Ostercamp, D. L.; Yousaf, T. I. Mechanisms of heterocyclic ring formations. 4. A carbon-13 NMR study of the reaction of b-keto esters with hvdroxylamine. J. Org. Chem. 1986, 51, 4037-4042.
-
(1986)
J. Org. Chem
, vol.51
, pp. 4037-4042
-
-
Katritzky, A.R.1
Barezynski, P.2
Ostercamp, D.L.3
Yousaf, T.I.4
-
14
-
-
0001873191
-
Tautomerism of heteroaromatic compounds with five-membered rings. I. 5-Hydroxyisoxazoles-5-isoxaxolones
-
Boulton, A. J.; Katritzky, A. R. Tautomerism of heteroaromatic compounds with five-membered rings. I. 5-Hydroxyisoxazoles-5-isoxaxolones. Tetrahedron 1961, 12, 41-50.
-
(1961)
Tetrahedron
, vol.12
, pp. 41-50
-
-
Boulton, A.J.1
Katritzky, A.R.2
-
15
-
-
43049120397
-
-
Franchini, P. F. Dipole moments and tautomerism of isoxazolin-5-ones. Corsie Semin. Chim. 1968, 14, 23-25.
-
Franchini, P. F. Dipole moments and tautomerism of isoxazolin-5-ones. Corsie Semin. Chim. 1968, 14, 23-25.
-
-
-
-
16
-
-
43049148102
-
Dipole moments of 5-substituted isoxazoles. 1. Dipole moments and tautomerism of isoxazolin-5-ones
-
Cencioni, R.; Franchini, P. F.; Orienti, M. Dipole moments of 5-substituted isoxazoles. 1. Dipole moments and tautomerism of isoxazolin-5-ones. Tetrahedron 1968, 24, 151-166.
-
(1968)
Tetrahedron
, vol.24
, pp. 151-166
-
-
Cencioni, R.1
Franchini, P.F.2
Orienti, M.3
-
17
-
-
43049087872
-
Azoles. LXXII. Unequivocal synthesis and tautomerism of 3-isoxazolones
-
Jacquier, R.; Petrus, C.; Petrus, F.; Verducci, J. Azoles. LXXII. Unequivocal synthesis and tautomerism of 3-isoxazolones. Bull. Soc. Chim. Fr. 1970, 197, 8-1985.
-
(1970)
Bull. Soc. Chim. Fr
, vol.197
, pp. 8-1985
-
-
Jacquier, R.1
Petrus, C.2
Petrus, F.3
Verducci, J.4
-
18
-
-
19944433629
-
Potent 4-Aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
-
Frolund, B.; Jensen, L. S.; Guandalini, L.; Canillo, C.; Vestergaard, H. T.; Kristiansen, U.; Nielsen, B.; Stensbol, T. B.; Madsen, C.; Krogsgaard-Larsen, P.; Liljefors, T. Potent 4-Aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists: synthesis, pharmacology, and molecular modeling. J. Med. Chem. 2005, 48, 427-439.
-
(2005)
J. Med. Chem
, vol.48
, pp. 427-439
-
-
Frolund, B.1
Jensen, L.S.2
Guandalini, L.3
Canillo, C.4
Vestergaard, H.T.5
Kristiansen, U.6
Nielsen, B.7
Stensbol, T.B.8
Madsen, C.9
Krogsgaard-Larsen, P.10
Liljefors, T.11
-
19
-
-
0008752661
-
-
Chan, A. W. K.; Crow, W. D.; Gosney, I. Isothiazole chemistry. X. Acylation, alkylation, and tautomerism in 3-hydroxyisothiazole. Tetrahedron 1970, 26, 2497-2506.
-
Chan, A. W. K.; Crow, W. D.; Gosney, I. Isothiazole chemistry. X. Acylation, alkylation, and tautomerism in 3-hydroxyisothiazole. Tetrahedron 1970, 26, 2497-2506.
-
-
-
-
20
-
-
27644589566
-
An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays
-
Laufer, S.; Thuma, S.; Peifer, C.: Greim, C.; Herweh, Y.; Albrecht, A.; Dehner, F. An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays. Anal. Biochem. 2005, 344, 135-137.
-
(2005)
Anal. Biochem
, vol.344
, pp. 135-137
-
-
Laufer, S.1
Thuma, S.2
Peifer, C.3
Greim, C.4
Herweh, Y.5
Albrecht, A.6
Dehner, F.7
-
21
-
-
0000826617
-
Hydrogen bonding properties of oxygen and nitrogen acceptors in aromatic heterocycles
-
Nobeli, I.; Price, S. L.; Lommerse, J. P. M.; Taylor, R. Hydrogen bonding properties of oxygen and nitrogen acceptors in aromatic heterocycles. J. Comput. Chem. 1997, 18, 2060-2074.
-
(1997)
J. Comput. Chem
, vol.18
, pp. 2060-2074
-
-
Nobeli, I.1
Price, S.L.2
Lommerse, J.P.M.3
Taylor, R.4
-
22
-
-
0011639217
-
Oxygen and nitrogen in competitive situations: Which is the hydrogen-bond acceptor?
-
Boehm, H. J.; Brode, S.; Hesse, U.; Klebe, G. Oxygen and nitrogen in competitive situations: which is the hydrogen-bond acceptor? Chem.-Eur. J. 1996, 2, 1509-1513.
-
(1996)
Chem.-Eur. J
, vol.2
, pp. 1509-1513
-
-
Boehm, H.J.1
Brode, S.2
Hesse, U.3
Klebe, G.4
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