Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates

Journal of Allergy and Clinical Immunology

Volumn 121, Issue 5, 2008, Pages 1287-1289

  Matangkasombut, Ponpan ^a,b   Pichavant, Muriel ^a   Yasumi, Takahiro ^a   Hendricks, Carrie ^c   Savage, Paul B ^d   DeKruyff, Rosemarie H ^a   Umetsu, Dale T ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN;

ADAPTIVE IMMUNITY; AIRWAY HYPERREACTIVITY; ASTHMA; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL FUNCTION; EFFECTOR CELL; HUMAN; INNATE IMMUNITY; LETTER; LUNG RESISTANCE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; TH2 CELL;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; GALACTOSYLCERAMIDES; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MACACA FASCICULARIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 43049088082     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.02.006     Document Type: Letter

References (10)

1. Akbari O., Stock P., Meyer E., Kronenberg M., Sidobre S., Nakayama T., et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 9 (2003) 582-588
2. Lisbonne M., Diem S., de Castro Keller A., Lefort J., Araujo L.M., Hachem P., et al. Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol 171 (2003) 1637-1641
3. Bendelac A., Savage P.B., and Teyton L. The biology of NKT cells. Annu Rev Immunol 25 (2007) 297-336
4. Meyer E.H., Goya S., Akbari O., Berry G.J., Savage P.B., Kronenberg M., et al. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A 103 (2006) 2782-2787
5. Coffman R.L., and Hessel E.M. Nonhuman primate models of asthma. J Exp Med 201 (2005) 1875-1879
6. Meyer E.H., DeKruyff R.H., and Umetsu D.T. T cells and NKT cells in the pathogenesis of asthma. Annu Rev Med 59 (2008) 281-292
7. Akbari O., Faul J.L., Hoyte E.G., Berry G.J., Wahlstrom J., Kronenberg M., et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med 354 (2006) 1117-1129
8. Vijayanand P., Seumois G., Pickard C., Powell R.M., Angco G., Sammut D., et al. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N Engl J Med 356 (2007) 1410-1422
9. Agea E., Russano A., Bistoni O., Mannucci R., Nicoletti I., Corazzi L., et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med 202 (2005) 295-308
10. Pichavant M., Goya S., Meyer E.H., Johnston R.A., Kim H.Y., Matangkasombut P., et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med (2008) [Epub ahead of print]