Non-linear time domain model of electropermeabilization: Effect of extracellular conductivity and applied electric field parameters

Journal of Electrostatics

Volumn 66, Issue 5-6, 2008, Pages 328-334

  Talele, Sadhana ^a   Gaynor, Paul ^b  

^a UNIVERSITY OF WAIKATO   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Bipolar pulses; Electroporation; Extracellular conductivity; Pore density

Indexed keywords

COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; ELECTRIC FIELDS; MATHEMATICAL MODELS; TIME DOMAIN ANALYSIS; WAVEFORM ANALYSIS;

BIPOLAR PULSES; ELECTRIC FIELD PARAMETERS; ELECTROPERMEABILIZATION; ELECTROPORATION; EXTRACELLULAR CONDUCTIVITY; PORE DENSITY;

ELECTROSTATICS;

COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; ELECTRIC FIELDS; ELECTROSTATICS; MATHEMATICAL MODELS; TIME DOMAIN ANALYSIS; WAVEFORM ANALYSIS;

EID: 43049087712     PISSN: 03043886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.elstat.2008.02.002     Document Type: Article

References (41)

1. Miklavcic D., and Kotnik T. Electroporation for electrochemotherapy and gene therapy. In: Markov M.S. (Ed). Bioelectromagnetic Medicine (2004), Marcel Dekker, New York 637-656 (Chapter 40)
2. Cemazar M., Miklavcic D., and Sersa G. Intrinsic sensitivity of tumor cells to bleomycin as an indicator of tumor response to electrochemotherapy. J. Cancer Res. 89 (1998) 328-333
3. Sersa G., and Electrochemotherapy. In: Jaroszeski M.J., Heller R., and Gilbert R. (Eds). Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells Methods in Molecular Medicine (2000), Humana Press, Totowa, New Jersey 119-133 (Chapter 6)
4. Sersa G., Novakovic S., and Miklavcic D. Potentiation of bleomycin antitumor effectiveness by electrotherapy. Cancer Lett. 69 (1993) 81-84
5. Mir L.M., Orlowski S., Belehradek J., and Paoletti C. Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer 27 (1991) 68-72
6. Mir L.M., Orlowski S., Belehradek J.J., Teissie J., Rols M., Sersa G., Miklavcic D., Gilbert R., and Heller R. Biomedical applications of electric pulses with special emphasis on antitumor electrochemotherapy. Bioelectrochem. Bioenergy 38 (1995) 203-207
7. Sersa G., Cemazar M., and Miklavcic D. Antitumor effectiveness of electrochemotherapy with cisdiamminedichloroplatinum (II) in mice. Cancer Res. 55 (1995) 3450-3455
8. Glass L.F., Fenske N.A., Jaroszeski M., Perrott R., Harvey D.T., Reintgen D.S., and Heller R. Bleomycin-mediated electrochemotherapy of basal cell carcinoma. J. Am. Acad. Dermatol. 34 (1996) 82-86
9. Sersa G., Stabuc B., Cemazar M., Miklavcic D., and Rudolf Z. Electrochemotherapy with cisplatin: the systemic antitumour effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the treatment of malignant melanoma skin metastases. Melanoma Res. 10 (2000) 381-385
10. Gothelf A., Mir L.M., and Gehl J. Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat. Rev. (2003) 1-17
11. S. Kranjc, M. Cemazar, A. Grosel, M. Sentjurc, G. Sersa, Radiosensitising effect of electrochemotherapy with bleomycin in lpb sarcoma cells and tumors in mice, BMC Cancer.
12. Tozon N., Kodre V., Sersa G., and Cemazar M. Effective treatment of perianal tumors in dogs with electrochemotherapy. Anticancer Res. 25 (2005) 839-946
13. Snoj M., Rudolf Z., Cemazar M., Jancar B., and Sersa G. Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy. Anti-Cancer Drugs 16 (2005) 345-348
14. Budak-Alpdogan T., Banerjee D., and Bertino J.R. Hematopoietic stem cell gene therapy with drug resistance genes: an update. Cancer Gene Ther. 12 (2005) 849-863
15. Zimmermann U. Electric field-mediated fusion and related electrical phenomena. Biochim. Biophys. Acta 694 (1982) 227-277
16. Scott-Taylor T.H., Pettengell R., Clarke I., Stuhler G., Barthe M.C.L., Walden P., and Dalgleish A.G. Human tumour and dendritic cell hybrids generated by electrofusion: potential for cancer vaccines. Biochem. Biophys. Acta 1500 (2000) 265-267
17. Orentas R., Schauer D., Bin Q., and Johnson B.D. Electrofusion of a weakly immunogenic neuroblastoma with dendritic cells produces a tumor vaccine. Cell. Immunol. 213 (2001) 4-13
18. Schmidt E., Leinfelder U., Gessner P., Zillikens D., Brocker E.B., and Zimmermann U. CD19+ B lymphocytes are the major source of human antibody-secreting hybridomas generated by electrofusion. J. Immunol. Methods 255 (2001) 93-102
19. Gaynor P.T., Wells D.N., and Oback B. Couplet alignment and improved electrofusion by dielectrophoresis for a zona-free high throughput cloned embryo production system. Med. Biol. Eng. Comput. 43 (2005) 150-154
20. Prausnitz M.R., Bose V.G., Langer R., and Weaver J.C. Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. USA 90 (1993) 10504-10508
21. Vanbever R., Lecouturier N., and Preat V. Transdermal delivery of metoprolol by electroporation. Pharmacol. Res. 11 (1994) 1657-1662
22. Mouneimne Y., Tosi P.F., Barhoumi R., and Nicolau C. Electroinsertion: an electrical method for protein implantation into cell membranes. In: Chang D.C., Chassy B.M., Saunders J.A., and Sowers A.E. (Eds). Guide to Electroporation and Electrofusion (1992), Academic Press, California 327-346 (Chapter 20)
23. Rols M.P., and Teissie J. Ionic-strength modulation of electrically induced permeabilization and associated fusion of mammalian cells. Eur. J. Biochem. 179 (1989) 109-115
24. Djuzenova C.S., Zimmermann U., Frank H., Sukhorukov V.L., Richter E., and Fuhr G. Effect of medium conductivity and composition on the uptake of propidium iodide into electropermeabilized myeloma cells. Biochem. Biophys. Acta 1284 (1996) 143-152
25. Pucihar G., Kotnik T., Kanduser M., and Miklavcic D. The influence of medium conductivity on electropermeabilization and survival of cells in vitro. Bioelectrochemistry 54 (2001) 107-115
26. Golzio M., Mora M.P., Raynaud C., Delteil C., Teissie J., and Rols M.P. Control by osmotic pressure of voltage-induced permeabilization and gene transfer in mammalian cells. Biophys. J. 74 (1998) 3015-3022
27. Rols M.P., Delteil C., Serin G., and Teissie J. Temperature effects on electrotransfection of mammalian cells. Nucleic Acids Res. 22 (1994) 540-541
28. DeBruin K.A., and Krassowska W. Modeling electroporation in a single cell, I. Effects of field strength and rest potential. Biophys. J. 77 (1999) 1213-1224
29. Tekle E., Astumian R., and Chock P. Electro-permeabilization of cell membranes: effect of the resting membrane potential. Biochem. Biophys. Res. Commun. 172 (1990) 282-287
30. Teissié J., and Rols M.P. An experimental evaluation of the critical potential difference inducing cell membrane electropermeabilization. Biophys. J. 65 (1993) 409-413
31. Mehrle W., Zimmermann U., and Hampp R. Evidence for asymmetrical uptake of fluorescent dyes through electro-permeabilized membranes of avena mesophyll protoplasts. FEBS Lett. 185 (1985) 89-94
32. Gabriel B., and Teissié J. Direct observation in the millisecond time range of fluorescent molecule asymmetrical interaction with the electropermeabilized cell membrane. Biophys. J. 73 (1997) 2630-2637
33. Kotnik T., Miklavcic D., and Mir L.M. Cell membrane electropermeabilization by symmetrical bipolar rectangular pulses, part II. Reduced electrolytic contamination. Bioelectrochemistry 54 (2001) 91-95
34. Talele S., and Gaynor P. Nonlinear time domain model of electropermeabilization: Response of a single cell to an arbitrary applied electric field. J. Electrostatics 65 (2007) 775-784
35. Lojewska Z., Franks D., Ehrenberg B., and Loew M. Analysis of the effect of medium and membrane conductance on the amplitude and kinetics of membrane potentials induced by externally applied electric fields. Biophys. J. 56 (1989) 121-128
36. Tekle E., Astumian R.D., and Chock P.B. Electroporation by using bipolar oscillating electric field: an improved method for DNA transfection of NIH 3T3 cells. Proc. Natl. Acad Sci. 66 (1991) 4230-4234
37. Foster K.R., and Schwan H.P. Dielectric properties of tissues. In: Polk C., and Postow E. (Eds). Handbook of Biological Effects of Electromagnetic Fields (1996), CRC Press, New York 25-97 (Chapter 1)
38. Grosse C., and Schwan H.P. Cellular membrane potentials induced by alternating fields. Biophys. J. 66 (1992) 1632-1642
39. Pavlin P., Pavselj N., and Miklavcic D. Dependence of induced transmembrane potential on cell density, and cell position inside a cell system. IEEE Trans. Biomed. Eng. 49 (2002) 605-612
40. Qin Y., Lai S., Jiang Y., Yangand T., and Wang J. Transmembrane voltage induced on a cell membrane in suspensions exposed to an alternating field: a theoretical analysis. Bioelectrochemistry 67 (2005) 57-65
41. Kotnik T. Biological cells in electric fields. Proceedings of the Electroporation based Technologies and Treatments (2003) 7-12