Portal vein hypertension with azathioprine therapy in patients with Crohn's disease - Is it a frequent phenomenon?;Portale hypertension unter azathioprin bei morbus Crohn - Ein häufiges phänomen?

Deutsche Medizinische Wochenschrift

Volumn 133, Issue 18, 2008, Pages 950-953

  Ehmsen, L ^a   Marko, C ^b   Breidert, Matthias ^a,c  

^a Medizinische Klinik I

^b Klinikum Lahr Ettenheim   (Germany)

^c Klinikum Mittelbaden   (Germany)

Author keywords

Azathioprine; Crohn's disease; Nodular regenerative hyperplasia

Indexed keywords

AZATHIOPRINE; ENBUCRILATE; LIVER ENZYME; IMMUNOSUPPRESSIVE AGENT;

ADULT; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; CROHN DISEASE; ENDOSCOPY; ESOPHAGUS VARICES; HEMATEMESIS; HUMAN; HUMAN TISSUE; LABORATORY TEST; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; LIVER HYPERPLASIA; LIVER TOXICITY; MALE; MELENA; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTPATIENT CARE; PORTAL HYPERTENSION; STOMACH FUNDUS; THROMBOCYTE COUNT; CHEMICALLY INDUCED DISORDER; LIVER; MIDDLE AGED; NODULAR HYPERPLASIA; PATHOLOGY;

AZATHIOPRINE; CROHN DISEASE; ENBUCRILATE; ESOPHAGEAL AND GASTRIC VARICES; FOCAL NODULAR HYPERPLASIA; HEMATEMESIS; HUMANS; HYPERTENSION, PORTAL; IMMUNOSUPPRESSIVE AGENTS; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MELENA; MIDDLE AGED;

EID: 42949161552     PISSN: 00120472     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1075672     Document Type: Article

References (11)

1. Arnott ID, Ghosh S. Portal hypertension in the presence of minimal liver damage in Crohn's disease on long-term azathioprine: possible endothelial cell injury. Eur J Gastroenterol Hepatol 2000; 12: 569-573
2. Buffet C, Cantarovitch M, Pelletier G et al. Three cases of nodular regenerative hyperplasia of the liver following renal transplantation. Nephrol Dial Transplant 1988; 3: 327-330
3. Carter MJ, Lobo AJ, Travis SP. IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53, Suppl 5: V1-16
4. Daniel F, Cadranel JF, Seksik P et al. Azathioprine induced nodular regenerative hyperplasia in IBD patients. Gastroenterol Clin Biol 2005; 29: 600-603
5. Dubinsky MC, Vasiliauskas EA, Singh H et al. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology 2003; 125: 298-303
6. Ferlitsch A, Teml A, Reinisch W et al. 6-thioguanine associated nodular regenerative hyperplasia in patients with inflammatory bowel disease may induce portal hypertension. Am J Gastroenterol 2007; 102: 2495-2503
7. Fischer H, Zhou H. Leberparenchymknoten bei pathologischer hepatischer Vaskularisation/Perfusion. Der Pathologe 2006; 27: 273-283
8. Gross M. Azathioprin in der Gastroenterologie. 1. Auflage. Bremen: Unimed, 2002: 19-24
9. Present DH, Meltzer SJ, Krumholz M, Wolke A, Korelitz BI. 6-Mercaptopurin in the management of inflammatory bowel disease: short-term and long term toxicity. Ann Intern Med 1989; 3: 641-649
10. Seiderer J, Zech CJ, Diebold J. Nodular regenerative hyperplasia: a reversible entity associated with azathioprine therapy. Eur J Gastroenterol Hepatol 2006; 18: 553-555
11. Teml A, Schwab M, Hommes DW et al. A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease. Wien Klin Wochenschr 2007; 119: 519-526