Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2840-2844

  Xie, Yuli ^a   Liu, Yidong ^a   Gong, Gangli ^a   Rinderspacher, Alison ^a   Deng, Shi Xian ^a   Smith, Deborah H ^a   Toebben, Udo ^a   Tzilianos, Effie ^a   Branden, Lars ^a   Vidović, Dušica ^b   Chung, Caty ^b   Schürer, Stephan ^b   Tautz, Lutz ^c   Landry, Donald W ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

Lyp; pTyr mimics; Salicylate; Thiazolidine

Indexed keywords

2 THIOXOTHIAZOLIDIN 4 ONE; ENZYME INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; THIAZOLIDINE 2,4 DIONE;

ANALYTIC METHOD; ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING;

BINDING SITES; ENZYME INHIBITORS; MODELS, CHEMICAL; MOLECULAR MIMICRY; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; PROTEIN TYROSINE PHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; THIAZOLIDINES;

EID: 42949146123     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.079     Document Type: Article

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