Application of optical coherence tomography for monitoring changes in cervicovaginal epithelial morphology in Macaques: Potential for assessment of microbicide safety

Sexually Transmitted Diseases

Volumn 35, Issue 3, 2008, Pages 269-275

  Vincent, Kathleen L ^a   Bell, Brent A ^a   Rosenthal, Susan L ^a   Stanberry, Lawrence R ^a   Bourne, Nigel ^a   Sweeney, Yvonne T Cosgrove ^b   Patton, Dorothy L ^b   Motamedi, Massoud ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROBICIDE; NONOXINOL 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLPOSCOPY; CONTROLLED STUDY; DRUG SAFETY; FEMALE; MACACA; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; SCORING SYSTEM; UTERINE CERVIX EPITHELIUM;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-INFECTIVE AGENTS; CERVIX UTERI; CONSUMER PRODUCT SAFETY; DISEASE MODELS, ANIMAL; EPITHELIUM; FEASIBILITY STUDIES; FEMALE; MACACA; PREDICTIVE VALUE OF TESTS; TOMOGRAPHY, OPTICAL COHERENCE; VAGINA;

EID: 42949135368     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/OLQ.0b013e31815abad8     Document Type: Article

References (24)

1. WHO/CONRAD Manual for the standardization of colposcopy for the evaluation of vaginal products, Update 2004. Punta Cana, Dominican Republic: CONRAD/WHO, 2004.
2. Van Damme L, Ramjee G, Alary M, et al. COL-1492 Study Group. Effectiveness of COL-1792, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomised controlled trial. Lancet 2002;360:971-977.
3. Kreiss J, Ngugi E, Holmes K, et al. Efficacy of nonoxynol-9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes. JAMA 1992;268:477- 482.
4. Hillier SL, Moench T, Shattock R, et al. In Vitro and In Vivo: The story of nonxynol-9. J Acquir Immun Defic Syndr 2005;39:1- 8.
5. Watts DH, Rabe L, Krohn MA, et al. The effects of three nonoxynol-9 preparations on the vaginal flora and epithelium. J Infect Dis 1999;180:426-437.
6. Tearney GJ, Brezinski ME, Bouma BE, et al. In vivo endoscopic optical biopsy with optical coherence tomography. Science 1997;276:2037-2039.
7. Gladkova ND, Petrova GA, Nikulin NK, et al. In vivo optical coherence tomography imaging of human skin: Normal and pathology. Skin Res Technol 2000:6:6 -16.
8. Escobar PF, Belinson JL, White A, et al. Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva. Int J Gynecol Cancer 2004;14:470-474.
9. Zuluaga AF, Follen M, Boiko I, et al. Optical coherence tomography: A pilot study of a new imaging technique for non-invasive examination of cervical tissue. Am J Obstet Gynecol 2005;193:83- 88.
10. Vincent KL, Levine L, Bell BA, et al. Optical coherence tomography in the evaluation of cervical dysplasia. Society of Gynecologic Oncologists, Feb 2003, New Orleans, LA. Available at: http://www.sgo.org/meetings/abstracts/abstract detail.cfm?ID=921. Accessed May 26, 2007.
11. Escobar PF, Rojas-Espaillat L, Tisci S, et al. Optical coherence tomography as a diagnostic aid to visual inspection and colposcopy for preinvasive and invasive cancer of the uterine cervix. Int J Gynecol Cancer 2006;16:1815-1822.
12. Shen B, Zuccaro G Jr, Gramlich TL, et al. In vivo colonoscopic optical coherence tomography for transmural inflammation in inflammatory bowel disease. Clin Gastroenterol Hepatol 2004;2:1080-1087.
13. Zagaynova EV, Streltsova OS, Gladkova NK, et al. In vivo optical coherence tomography feasibility for bladder disease. J Urol 2002;167:1492-1496.
14. Welzel J, Bruhns M, Wolff HH. Optical coherence tomography in contact dermatitis and psoriasis. Arch Dermatol Res 2003;295:50-55.
15. Raffel OC, Tearney GJ, Gauthier DD, et al. Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography. Arterioscler Thromb Vasc Biol 2007;27:1820-1827.
16. Hsiung P-L, Pantanowitz L, Aguirre AD, et al. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc 2005;62:561-574.
17. WHO/CONRAD Manual for the standardization of colposcopy for the evaluation of vaginal products, Update 2000. Geneva: CONRAD/WHO, 2000.
18. Patton DL, Kidder GG, Cosgrove-Sweeney Y, et al. Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina). Am J Obstet Gynecol 1999;180:1080-1087.
19. Patton DL, Cosgrove Sweeney YT, McCarthy TD, et al. Preclinical Safety and Efficacy Assessments of Dendrimer-Based (SPL7013) Microbicide Gel Formulations in a Nonhuman Primate Model. AAC 2006;50:1696 -1700.
20. Poonia B, Walter L, Dufour J, et al. Cyclic changes in the vaginal epithelium of normal rhesus macaques. J Endocrinol 2006;190, 829-835.
21. Njoroge B, Bukusi E, Nguti R, et al. Colposcopy findings before and after diaphragm use. Microbicides 2006, April 2006, Cape Town, South Africa. Available at: http://www.cervicalbarriers.org/documents/ Njoroge_Colposcopyfindingsbeforeandafterdiaphragmuse.doc. Accessed May 26, 2007.
22. Patton DL, Cosgrove-Sweeney YT, Balkus JE, et al. Vaginal and rectal topical microbicide development: Safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque. Sex Transm Dis 2006;33:691- 695.
23. Pitris C, Goodman A, Boppart SA, et al. High-resolution imaging of gynecologic neoplasms using optical coherence tomography. Obstet Gynecol 1999;93:135-139.
24. Ma Z, Lu FX, Torten M, et al. The number and distribution of immune cells in the cervicovaginal mucosa remain constant throughout the menstrual cycle of rhesus macaques. Clin Immunology. 2001;V100:240-249.