Improving the evidence base for treatment of juvenile idiopathic arthritis: The challenge and opportunity facing the MCRN/ARC Paediatric Rheumatology Clinical Studies Group

Rheumatology

Volumn 47, Issue 5, 2008, Pages 563-566

  Thornton, Judith ^a   Beresford, M W ^b   Clayton, P ^a,c  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; CORTICOSTEROID; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; HYBRID PROTEIN; IMMUNOGLOBULIN; INFLIXIMAB; METHOTREXATE; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

B CELL DEPLETION; B LYMPHOCYTE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONSUMER ADVOCACY; CONTROLLED CLINICAL TRIAL; DISEASE CLASSIFICATION; DRUG EFFICACY; DRUG INDUSTRY; DRUG LEGISLATION; DRUG RESEARCH; DRUG RESPONSE; DRUG SAFETY; EDITORIAL; EVIDENCE BASED MEDICINE; GOOD CLINICAL PRACTICE; HUMAN; IDIOPATHIC DISEASE; INTERNATIONAL COOPERATION; JUVENILE RHEUMATOID ARTHRITIS; LYMPHOCYTE DEPLETION; METHODOLOGY; OFF LABEL DRUG USE; OSTEOPENIA; PATENT; PRIORITY JOURNAL; QUALITY CONTROL; SAMPLE SIZE; SYMPTOMATOLOGY;

ARTHRITIS, JUVENILE RHEUMATOID; CHILD; EVIDENCE-BASED MEDICINE; GREAT BRITAIN; HUMANS; PEDIATRICS; RHEUMATOLOGY;

EID: 42949116861     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ken055     Document Type: Editorial

References (32)

1. Feldman BM. Treating children with arthritis: Towards an evidenoe-based culture. J Rheumatol 2005;32(Suppl 72):33-5.
2. Hashkes PJ, Laxer RM. Medical treatment of juvenile idiopathic arthritis. JAMA 2005;294:1671-84.
3. Abrahamyam L, Johnson S, Beyene J et al. Quality of randomised clinical trials in juvenile idiopathic arthritis. Rheumatology 2008;47:640-5.
4. Strand V, Kimberly R, Isaacs JD. Biologic therapies in rheumatology: lessons learned, future directions. Nat Rev Drug Discov 2007;6:75-92.
5. Gartlehner G, Hansen RA, Jonas BL et al. Biologics for the treatment of juvenile idiopathic arthritis: A systematic review and critical analysis of the evidence. Clin Rheumatol 2008;27:67-76.
6. Ruperto N, Lovell DJ, Cuttica R et al. A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 2007;56:3096-106.
7. Giannini EH, Ruperto N, Prieur AM et al. Efficacy of abatacept in different subpopulations of juvenile idiopathic arthritis (JIA): Results of a randomized withdrawal study. Arthritis Rheum 2007;56(Suppl):S291.
8. Lovell DJ, Ruperto N, Prieur AM et al. Abatacept treatment of juvenile idiopathic arthritis (JIA): Safety report. Arthritis Rheum 2007;56(Suppl):S292.
9. Lovell DJ, Ruperto N, Goodman S et al. Adalimumab for the treatment of patients with juvenile rheumatoid arthritis: Safety and efficacy after conversion from body-surface-area dosing to weight-based fixed dosing. Arthritis Rheum 2007;56(Suppl):S373.
10. Lovell DJ, Ruperto N, Goodman S et al. Adalimumab is safe and effective during long-term treatment of patients with juvenile rheumatoid arthritis: Results from a 2-year study. Arthritis Rheum 2007;56(Suppl):S292.
11. Revelli A, Martini A. Remission in juvenile idiopathic arthritis. Clin Exp Rheumatol 2006;243:S105-110.
12. Hiraki LT, Hamilton J, Silverman ED. Measuring permanent damage in pediatric systemic lupus erythematosus. Lupus 2007;16:657-62.
13. Zipitis CS, Baildam EM, Ramanan AV. Treatment approaches to juvenile dermatomyositis. Expert Opin Pharmacother 2004;5:1509-15.
14. MacDermott EJ, Adams A, Lehman TJ. Systemic lupus erythematosus in children: Current and emerging therapies. Lupus 2007;16:677-83.
15. Ruperto N, Martini A. International research networks in pediatric rheumatology: The PRINTO perspective. Curr Opin Rheumatol 2004;16:566-70.
16. Beresford MW. Development of a national multi-cantre, multi-disciplinary collaborative Registry & Repository of patients with Juvenile-onset SLE (JSLE). Abstract. Lupus 2007;16(Suppl.):49.
17. Cohen E, Uleryk E, Jasuja M, Parkin PC. An absence of paediatric randomized controlled trials in general medical journals, 1985-2004. J Clin Epidemiol 2007;60:118-23.
18. Campbell H, Surry SAM, Royle EM. A review of randomised controlled trials published in Archives of Disease in Childhood from 1982-96. Arch Dis Child 1998;79:192-7.
19. Cramer K, Wiebe N, Moyer V et al. Children in reviews: methodological issues in child-relevant evidence syntheses. BMC Pediatrics 2005;5:38.
20. Conroy S, Choonara I, Impicciatore P et al. Survey of unlicensed and off label drug use in paediatric wards in European countries. Br Med J 2000;320:79-82.
21. Turner S, Longworth A, Nunn AJ, Choonara I. Unlicensed and off label drug use in paediatric wards: Prospective study. Br Med J 1998;316:343-5.
22. McIntyre J, Conreo S, Avery A, Choonara I. Unlicensed and off label prescribing of drugs in general practice. Arch Dis Child 2000;83:498-501.
23. Conroy S, McIntryre J, Choonara I. Unlicensed and off label drug use in neonates. Arch Dis Child Neonatal Ed 1999;80:F142-5.
24. European Medicines Agency. Evidence of harm from off label or unlicensed medicines in children. http://www.emea.europa.eu/pdfs/human/paediatrics/ 57578807en.pdf (7 January 2008, date last accessed).
25. Schirm E, Tobi H, de Vries TW et al. Lack of appropriate formulations of medicines for children in the community. Acta Paediatrica 2003;92:1486-9.
26. Nunn T, Williams J. Formulation of Medicines for Children. British J Clin Pharmacol 2005;59:674-6.
27. Stephenson T. 'Bonne Annee', 'Gutes Nueus Jahr'? Will 2007 be a 'Happy New Year' for children's medicines in Europe? Arch Dis Child 2007;92:661-3.
28. FDA Federal Register. Paediatric studies requirements: Safety and effectiveness of drugs and biological products for children, 66631-66674 [FR doc 98-31902]. http://frwebgate.access.gpo.gov/cgi-bin/ getdoc.cgi?dbname=1998_register&docid=9831902-filed.pdf (7 January 2008, date last accessed).
29. EUR-Lex. Legislation. Official Journal of the European Union 27 December 2006, L 378, vol 49. http://eur-lex.europa.eu/ JOHtml.do?uri=OJ:L:2006:378:SOM:EN:HTML (7 January 2008, date last accessed).
30. Department of Health. Best research for best health: Introducing a new national health research strategy. London DoH, 2006. http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/ documents/digitalasset/dh_4127153.pdf (7 January 2008, date last accessed).
31. Smyth RL. Making a difference: The clinical research programme for children. Arch Dis Childhood 2007;92:835-7.
32. Silman A. A new paradigm for musculoskeletal clinical trials in the UK: the Arthritis Research Campaign (arc) Clinical Studies Group initiative. Rheumatology 2008, (in press).