Conformation-activity relationship on novel 4-pyridylmethylthio derivatives with antiangiogenic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2939-2943

  Honda, Takahiro ^a,b   Tajima, Hisashi ^a   Kaneko, Yasushi ^b   Ban, Masakazu ^a,b   Inaba, Takaaki ^a   Takeno, Yuriko ^a   Okamoto, Kazuyoshi ^a   Aono, Hiroyuki ^a,b  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

4 Pyridylmethylthio derivative; A nonbonded intramolecular interaction; VEGF receptor2 tyrosine kinase

Indexed keywords

ANGIOGENESIS INHIBITOR; CARBONYL DERIVATIVE; PYRIDINE DERIVATIVE; SULFUR; VASCULOTROPIN RECEPTOR 2; VATALANIB;

AB INITIO CALCULATION; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; MOLECULAR INTERACTION; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; UMBILICAL VEIN; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; ANGIOGENESIS INHIBITORS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; PHTHALAZINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 42949115512     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.068     Document Type: Article

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