IgG antibodies to plasminogen and their relationship to IgG anti-β2-glycoprotein 1 antibodies and thrombosis

Clinical Rheumatology

Volumn 27, Issue 2, 2008, Pages 171-178

  Bu, Chunya ^a   Li, Zhihuan ^a   Zhang, Chune ^a   Gao, Lei ^a   Cai, Guoping ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Antiphospholipid syndrome; Plasminogen; Systemic lupus erythematosus; Thrombosis; 2 Glycoprotein 1

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; CROSS REACTING ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; LUPUS ANTICOAGULANT; PLASMINOGEN; BETA2 GLYCOPROTEIN 1;

ANTICOAGULATION; ANTIGEN BINDING; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROSS REACTION; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRINOLYSIS; HUMAN; IMMUNOBLOTTING; IMMUNODIFFUSION; MEDICAL HISTORY; PARTIAL THROMBOPLASTIN TIME; PREVALENCE; PRIORITY JOURNAL; PROTEIN PURIFICATION; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOSIS; BLOOD; IMMUNOLOGY;

ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; HUMANS; IMMUNOGLOBULIN G; LUPUS COAGULATION INHIBITOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; PLASMINOGEN; THROMBOSIS;

EID: 42949101669     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-007-0673-3     Document Type: Article

References (32)

1. Esmon CT (2000) Regulation of blood coagulation. Biochim Biophys Acta 1477:349–360
2. Yang CD, Hwang KK, Yan W et al (2004) Identification of antiplasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin. J Immunol 172:5765–5773
3. Yasuda S, Atsumi T, Ieko M, Koike T (2004) Beta2-glycoprotein I, anti-beta2-glycoprotein I, and fibrinolysis. Thromb Res 114:461–465
4. Ieko M, Sawada KI, Koike T et al (1999) The putative mechanism of thrombosis in antiphospholipid syndrome: impairment of the protein C and the fibrinolytic systems by monoclonal anticardiolipin antibodies. Semin Thromb Hemost 25:503–507
5. Ieko M, Ichikawa K, Atsumi T et al (2000) Effects of beta2- glycoprotein I and monoclonal anticardiolipin antibodies on extrinsic fibrinolysis. Semin Thromb Hemost 26:85–90
6. de Groot PG, Derksen RH (2005) Pathophysiology of the antiphospholipid syndrome. J Thromb Haemost 3:1854–1860
7. Stefanescu M, Szegli G, Cremer L et al (1989) The presence and significance of some anti-enzyme antibodies (anti-plasminogen, anti-trypsin, anti-phospholipase C) in rheumatoid arthritis (RA) and reactive arthritis (rA). Arch Roum Pathol Exp Microbiol 48:47–53
8. Gonzalez-Gronow M, Cuchacovich M, Grigg DM, Pizzo SV (1996) Analysis of autoantibodies to plasminogen in the serum of patients with rheumatoid arthritis. J Mol Med 74:463–469
9. Kozmin LD, Shirokova IE, Lisitsina TA et al (2003) Antiplasminogen autoantibodies from plasma of patients with systemic lupus erythematosus having anti-phospholipid antibody syndrome: isolation and some immunochemical properties. Biochemistry (Mosc) 68:339–345
10. Simmelink MJ, De Groot PG, Derksen RH (2003) A study on associations between antiprothrombin antibodies, antiplasminogen antibodies and thrombosis. J Thromb Haemost 1:735–739
11. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990) Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2- glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 87:4120–4124
12. Galli M, Comfurius P, Maassen C et al (1990) Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 335:1544–1547
13. Reber G, de Moerloose P (2004) Anti-beta2-glycoprotein I antibodies-when and how should they be measured? Thromb Res 114:527–531
14. Miyakis S, Giannakopoulos B, Krilis SA (2004) Beta 2 glycoprotein I-function in health and disease. Thromb Res 114:335–346
15. Lopez-Lira F, Rosales-Leon L, Martinez VM, Ruiz Ordaz BH (2006) The role of beta2-glycoprotein I (beta(2)GPI) in the activation of plasminogen. Biochim Biophys Acta 1764:815–823
16. Yasuda S, Atsumi T, Ieko M, et al (2004) Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis. Blood 103:3766–3772
17. Zhu M, Olee T, Le DT et al (1999) Characterization of IgG monoclonal anti-cardiolipin/anti-beta2GP1 antibodies from two patients with antiphospholipid syndrome reveals three species of antibodies. Br J Haematol 105:102–109
18. Hwang KK, Grossman JM, Visvanathan S et al (2001) Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin. J Immunol 167:7192–7198
19. Hwang KK, Yang CD, Yan W, Grossman JM, Hahn BH, Chen PP (2003) A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C. Arthritis Rheum 48:1622–1630
20. Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295–306
21. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725
22. Brandt JT, Triplett DA, Alving B, Scharrer I (1995) Criteria for the diagnosis of lupus anticoagulants: an update. Thromb Haemost 74:1185–1190
23. Cai G, Guo Y, Shi J (1996) Purification of apolipoprotein H by polyethylene glycol precipitation. Protein Expr Purif 8:341–346
24. Goding JW (1986) Monoclonal antibodies: principles and practice, 2nd edn. Academic, London
25. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC (2004) Proposals for the measurement of anti-beta2-glycoprotein I antibodies. J Thromb Haemost 2:1860–1862
26. Cesarman GM, Guevara CA, Hajjar KA (1994) An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J Biol Chem 269:21198–21203
27. Cugno M, Dominguez M, Cabibbe M et al (2000) Antibodies to tissue-type plasminogen activator in plasma from patients with primary antiphospholipid syndrome. Br J Haematol 108:871–875
28. Cugno M, Cabibbe M, Galli M et al (2004) Antibodies to tissuetype plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients. Blood 103:2121–2126
29. Puurunen M, Manttari M, Manninen V, Palosuo T, Vaarala O (1998) Antibodies to prothrombin crossreact with plasminogen in patients developing myocardial infarction. Br J Haematol 100: 374–379
30. Puurunen M, Palosuo T, Lassila R, Anttila M, Vaarala O (2001) Immunologic and hematologic properties of antibodies to prothrombin and plasminogen in a mouse model. Lupus 10:108–115
31. Erkan D, Zhang HW, Shriky RC, Merrill JT (2002) Dual antibody reactivity to beta2-glycoprotein I and protein S: increased association with thrombotic events in the antiphospholipid syndrome. Lupus 11:215–220
32. Lu CS, Horizon AA, Hwang KK et al (2005) Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 52:4018–4027