Bone modeling response to voluntary exercise in the hindlimb of mice

Journal of Morphology

Volumn 269, Issue 3, 2008, Pages 313-318

  Plochocki, Jeffrey H ^a   Rivera, Janelyn P ^a   Zhang, Cathleen ^a   Ebba, Sahbina A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Biomechanics; Bone modeling; Limb tapering; Mice

Indexed keywords

MAMMALIA; MUS;

ADAPTATION; ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; C57BL MOUSE; FEMALE; FEMUR; HINDLIMB; HISTOLOGY; MECHANICAL STRESS; MOUSE; PHYSIOLOGY; TIBIA;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BONE DENSITY; BONE DEVELOPMENT; FEMALE; FEMUR; HINDLIMB; MICE; MICE, INBRED C57BL; PHYSICAL CONDITIONING, ANIMAL; STRESS, MECHANICAL; TIBIA;

EID: 42949092042     PISSN: 03622525     EISSN: 10974687     Source Type: Journal    
DOI: 10.1002/jmor.10587     Document Type: Article

References (42)

1. Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. 1998. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tissue Int 63:442-449.
2. Alexander RM. 1998. Symmorphosis and safety factors. In: Weibel ER, Taylor CR, Bolis L, editors. Principles of Animal Design: The Optimization and Symmorphosis Debate. Cambridge: Cambridge University Press. pp 28-35.
3. Bertram J, Biewener AA. 1988. Bone curvature: Sacrificing strength for load predictability? J Theor Biol 131:75-92.
4. Biewener AA. 1983. Allometry of quadrupedal locomotion: The scaling of duty factor, bone curvature and limb orientation to body size. J Exp Biol 105:147-171.
5. Biewener AA, Bertram J. 1994. Structural response of growing bone to exercise and disuse. J Appl Physiol 76:946-955.
6. Biewener AA, CR Taylor. 1986. Bone strain: A determinant of gait and speed? J Exp Biol 123:383-400.
7. Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ. 2001. Aged bone displays an increased responsiveness to low-intensity resistance exercise. J Appl Physiol 90:1359-1364.
8. Cowin SC, Moss ML. 2001. Mechanosensory mechanisms in bone. In: Cowin SC, editor. Bone Biomechanics Handbook, 2nd ed. Boca Raton: CRC Press. pp 29-1-29-17.
9. Currey JD. 1984. The Mechanical Adaptation of Bones. Princeton, NJ: Princeton University Press.
10. Currey JD, Alexander RM. 1985. The thickness of the walls of tubular bones. J Zool Lond A 206:453-468.
11. Dellanini L, Hawkins D, Martin RB, Stover S. 2003. An investigation of the interactions between lower-limb bone morphology, limb inertial properties and limb dynamics. J Biomech 36:913-919.
12. Drapeau MS, Streeter MA. 2006. Modeling and remodeling responses to normal loading in the human lower limb. Am J Phys Anthropol 129:403-409.
13. Frost HM. 1994. Wolff's law and bone's structural adaptations to mechanical usage: An overview for clinicians. Angle Orthod 64:175-188.
14. Frost HM. 1999. An approach to estimating bone and joint loads and muscle strength in living subjects and skeletal remains. Am J Hum Biol 11:437-455.
15. Frost HM. 2003. Bone's mechanostat: A 2003 update. Anat Rec A 275:1081-1101.
16. Garcia GJ, da Silva JK. 2004. On the scaling of mammalian long bones. J Exp Biol 207:1577-1584.
17. Hamrick MW. 1999. A chondral modeling theory revisited. J Theor Biol 201:201-208.
18. Hamrick MW, McPherron AC, Lovejoy CO, Hudson J. 2000. Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice. Bone 27:343-349.
19. Hildebrand M. 1985. Walking and running. In: Hildebrand M, Bramble DM, Liem KF, Wake DB, editors. Functional Vertebrate Morphology. Cambridge: Harvard University Press. pp 38-57.
20. Hildebrand M, Hurley J. 1985. Energy of the oscillating legs of a fast-moving cheetah, pronghorn, jackrabbit, and elephant. J Morphol 184:23-31.
21. Judex S, Zernicke RF. 2000. High-impact exercise and growing bone: Relation between high strain rates and enhanced bone formation. J Appl Physiol 88:2183-2191.
22. Kaye M, Kusy RP. 1995. Genetic lineage, bone mass, and physical activity in mice. Bone 17:131-135.
23. Kelly SA, Czech PP, Wight JT, Blank KM, Garland T Jr. 2006. Experimental evolution and phenotypic plasticity of hindlimb bones in high-activity house mice. J Morphol 267:360-374.
24. Lieberman DE, Devlin MJ, Pearson OM. 2001. Articular area responses to mechanical loading: Effects of exercise, age, and skeletal location. Am J Phys Anthropol 116:266-277.
25. Lieberman DE, Pearson OM, Polk JD, Demes B, Crompton AW. 2003. Optimization of bone growth and remodeling in response tapered mammalian limbs. J Exp Biol 206:3125-3138.
26. Lieberman DE, Polk JD, Demes B. 2004. Predicting long bone loading from cross-sectional geometry Am J Phys Anthropol 123:156-171.
27. Martin RB, Burr DB, Sharkey NA. 1998. Skeletal Tissue Mechanics. New York: Springer-Verlag.
28. Matsuda JJ, Zernicke RF, Vailas AC, Pedrini VA, Pedrini-Mille A, Maynard JA. 1986. Structural and mechanical adaptation of immature bone to strenuous exercise. J Appl Physiol 60:2028-2034.
29. Milgrom C, Giladi M, Simkin A, Rand N, Kedem R, Kashtan H, Stein M, Gomori M. 1989. The area moment of inertia of the tibia - A risk factor for stress-fractures. J Biomech 22:1243-1248.
30. Montgomery E, Pennington C, Isales CM, Hamrick MW. 2005. Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice. Anat Rec A 286:814-822.
31. Myers MJ, Steudel K. 1985. Effect of limb mass and its distribution on the energetic cost of running. J Exp Biol 116:363-373.
32. O'Neill MC, Ruff CB. 2004. Estimating human long bone cross-sectional geometric properties: A comparison of noninvasive methods. J Hum Evol 47:221-235.
33. Pauwels F. 1980. Biomechanics of the Locomotor Apparatus. Berlin: Springer-Verlag.
34. Pearson OM, Lieberman DE. 2004. The aging of Wolff's law. Yrbk Phys Anthropol 47:63-99.
35. Pedersen EA, Akhter MP, Cullen DM, Kimmel DB, Recker RR. 1999. Bone response to in vivo mechanical loading in C3H/HeJ mice. Calcif Tissue Int 65:41-46.
36. Raab-Cullen DM, Akhter MP, Kimmel DB, Recker RR. 1994. Bone response to alternate-day mechanical loading of the rat tibia. J Bone Miner Res 9:203-211.
37. Raichlen DA. 2006. Effects of limb mass distribution on mechanical power outputs during quadrupedalism. J Exp Biol 209:633-644.
38. Robling AG, Turner CH. 2002. Mechanotransduction in bone: Genetic effects on mechanosensitivity in mice. Bone 31:562-569.
39. Ruff CB. 2000. Body size, body shape, and long bone strength in modern humans. J Hum Evol 38:269-290.
40. Schoenau E, Frost HM. 2002. The "muscle-bone unit" in children and adolescents. Calcif Tissue Int 70:405-407.
41. Sheng MH, Baylink DJ, Beamer WG, Donahue LR, Rosen CJ, Lau KH, Wergedal JE. 1999. Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone 25:421-429.
42. Woo SL-Y, Kuei SC, Amiel D, Gomez MA, Hayes WC, White FC, Akeson WH. 1981. The effect of prolonged physical training on the properties of the long bone: A study of Wolff's law. J Bone Joint Surg 63:780-787.