메뉴 건너뛰기




Volumn 93, Issue 24, 2004, Pages

Limited slowdown of endocrine-disruptor diffusion in confined fluid lipid membranes

Author keywords

[No Author keywords available]

Indexed keywords

BISPHENOL A (BPA); FIELD GRADIENT (FG) COILS; LARGE UNILAMELLAR VESICLES (LUV); PULSED FIELD GRADIENT (PFG); SMALL UNILAMELLAR VESICLES (SUV);

EID: 42749098414     PISSN: 00319007     EISSN: None     Source Type: Journal    
DOI: 10.1103/PhysRevLett.93.248101     Document Type: Article
Times cited : (18)

References (25)
  • 10
  • 13
    • 11844283886 scopus 로고    scopus 로고
    • note
    • -1). The diffusion coefficients were obtained by the least-square analysis of 6-10 experimental points of the echo signal attenuation. The experimental uncertainty was within ± 10%. The drugs used in this study are preferentially partitioned into membrane because they are highly lipophilic. This is confirmed by no variation of the drug diffusion coefficient when the drug concentration is changed in the range from one to 25 mol%. Thus the drug diffusion between aggregates can be negligible on the experimental time scale. The trapped amount of the drug in membrane is under equilibrium, judging from the NMR signal before and after the diffusion measurement.
  • 15
  • 17
  • 19
    • 11844298926 scopus 로고    scopus 로고
    • note
    • 1H NMR signal intensity, is 0.3 mM at 30°C. Our determination of D illustrates the high sensitivity of the apparatus.
  • 21
    • 11844294842 scopus 로고    scopus 로고
    • note
    • When the drug is trapped in the membrane for a sufficiently long time, the mean-square displacements of the drug and membrane molecules need to be coincident with each other in the long-time limit The diffusion coefficients obtained in the present study are the ones through the fit to the equation appearing in Ref. [13]. In other words, our D is an "effective" one conditioned by the experimental time scale. If the time scale is not long enough, the D of the drug is not necessarily equal to the D of the membrane molecule, while it is a certain measure of the molecular mobility in the aggregate.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.