Activation of the glucocorticoid receptor releases unstimulated PBMCs from an early block in HIV-1 replication

Virology

Volumn 375, Issue 1, 2008, Pages 73-84

  Wiegers, Klaus ^a   Schwarck, Doreen ^b   Reimer, Rudolph ^a   Bohn, Wolfgang ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b Clinical Research Unit

Author keywords

Dexamethasone; Gag; Glucocorticoid receptor; HIV; PBMCs; Preintegration complex; Provirus; Rat glioma cells; Vpr

Indexed keywords

GLUCOCORTICOID RECEPTOR; STEROID; VPR PROTEIN;

ARTICLE; CELL LINE; CELL NUCLEUS; CYTOPLASM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; VIRUS DNA CELL DNA INTERACTION; VIRUS REPLICATION;

CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; HIV CORE PROTEIN P24; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, GLUCOCORTICOID; STEROIDS; VIRUS REPLICATION; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS;

EID: 42749095535     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.01.037     Document Type: Article

References (56)

1. Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., and Martin M.A. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59 2 (1986) 284-291
2. Agostini I., Navarro J.M., Bouhamdan M., Willetts K., Rey F., Spire B., Vigne R., Pomerantz R., and Sire J. The HIV-1 Vpr co-activator induces a conformational change in TFIIB. FEBS Lett. 450 3 (1999) 235-239
3. Aiken C. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J. Virol. 71 8 (1997) 5871-5877
4. Ayyavoo V., Mahalingam S., Rafaeli Y., Kudchodkar S., Chang D., Nagashunmugam T., Williams W.V., and Weiner D.B. HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitro. J. Leukoc. Biol. 62 1 (1997) 93-99
5. Bamberger C.M., Schulte H.M., and Chrousos G.P. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr. Rev. 17 3 (1996) 245-261
6. Bieniasz P.D., and Cullen B.R. Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. J. Virol. 74 21 (2000) 9868-9877
7. Bishop K.N., Holmes R.K., Sheehy A.M., Davidson N.O., Cho S.J., and Malim M.H. Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr. Biol. 14 15 (2004) 1392-1396
8. Blaak H., van't Wout A.B., Brouwer M., Hooibrink B., Hovenkamp E., and Schuitemaker H. In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline. Proc. Natl. Acad. Sci. U. S. A. 97 3 (2000) 1269-1274
9. Chiu Y.L., Soros V.B., Kreisberg J.F., Stopak K., Yonemoto W., and Greene W.C. Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature 435 7038 (2005) 108-114
10. Chun T.W., Stuyver L., Mizell S.B., Ehler L.A., Mican J.A., Baseler M., Lloyd A.L., Nowak M.A., and Fauci A.S. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. U. S. A. 94 24 (1997) 13193-13197
11. Clavel F., and Charneau P. Fusion from without directed by human immunodeficiency virus particles. J. Virol. 68 2 (1994) 1179-1185
12. Cohen E.A., Dehni G., Sodroski J.G., and Haseltine W.A. Human immunodeficiency virus vpr product is a virion-associated regulatory protein. J. Virol. 64 6 (1990) 3097-3099
13. Connor R.I., Chen B.K., Choe S., and Landau N.R. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 206 2 (1995) 935-944
14. Fear W.R., Kesson A.M., Naif H., Lynch G.W., and Cunningham A.L. Differential tropism and chemokine receptor expression of human immunodeficiency virus type 1 in neonatal monocytes, monocyte-derived macrophages, and placental macrophages. J. Virol. 72 2 (1998) 1334-1344
15. Felzien L.K., Woffendin C., Hottiger M.O., Subbramanian R.A., Cohen E.A., and Nabel G.J. HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. Proc. Natl. Acad. Sci. U. S. A. 95 9 (1998) 5281-5286
16. Fouchier R.A., Meyer B.E., Simon J.H., Fischer U., Albright A.V., Gonzalez-Scarano F., and Malim M.H. Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex. J. Virol. 72 7 (1998) 6004-6013
17. Furth P.A., Westphal H., and Hennighausen L. Expression from the HIV-LTR is stimulated by glucocorticoids and pregnancy. AIDS Res. Hum. Retroviruses 6 4 (1990) 553-560
18. Ghosh D. Glucocorticoid receptor-binding site in the human immunodeficiency virus long terminal repeat. J. Virol. 66 1 (1992) 586-590
19. Heinzinger N.K., Bukinsky M.I., Haggerty S.A., Ragland A.M., Kewalramani V., Lee M.A., Gendelman H.E., Ratner L., Stevenson M., and Emerman M. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc. Natl. Acad. Sci. U. S. A. 91 15 (1994) 7311-7315
20. Keppler O.T., Welte F.J., Ngo T.A., Chin P.S., Patton K.S., Tsou C.L., Abbey N.W., Sharkey M.E., Grant R.M., You Y., Scarborough J.D., Ellmeier W., Littman D.R., Stevenson M., Charo I.F., Herndier B.G., Speck R.F., and Goldsmith M.A. Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1. J. Exp. Med. 195 6 (2002) 719-736
21. Kimata J.T., Mozaffarian A., and Overbaugh J. A lymph node-derived cytopathic simian immunodeficiency virus Mne variant replicates in nonstimulated peripheral blood mononuclear cells. J. Virol. 72 1 (1998) 245-256
22. Kino T., and Pavlakis G.N. Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. DNA Cell Biol. 23 4 (2004) 193-205
23. Kino T., Gragerov A., Kopp J.B., Stauber R.H., Pavlakis G.N., and Chrousos G.P. The HIV-1 virion-associated protein vpr is a co-activator of the human glucocorticoid receptor. J. Exp. Med. 189 1 (1999) 51-62
24. Kino T., Kopp J.B., and Chrousos G.P. Glucocorticoids suppress human immunodeficiency virus type-1 long terminal repeat activity in a cell type-specific, glucocorticoid receptor-mediated fashion: direct protective effects at variance with clinical phenomenology. J. Steroid. Biochem. Mol. Biol. 75 4-5 (2000) 283-290
25. Kino T., Gragerov A., Slobodskaya O., Tsopanomichalou M., Chrousos G.P., and Pavlakis G.N. Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators. J. Virol. 76 19 (2002) 9724-9734
26. Kinter A.L., Biswas P., Alfano M., Justement J.S., Mantelli B., Rizzi C., Gatti A.R., Vicenzi E., Bressler P., and Poli G. Interleukin-6 and glucocorticoids synergistically induce human immunodeficiency virus type-1 expression in chronically infected U1 cells by a long terminal repeat independent post-transcriptional mechanism. Mol. Med. 7 10 (2001) 668-678
27. Konvalinka J., Litterst M.A., Welker R., Kottler H., Rippmann F., Heuser A.M., and Krausslich H.G. An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity. J. Virol. 69 11 (1995) 7180-7186
28. Mangeat B., Turelli P., Caron G., Friedli M., Perrin L., and Trono D. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 424 6944 (2003) 99-103
29. Mariani R., Rutter G., Harris M.E., Hope T.J., Krausslich H.G., and Landau N.R. A block to human immunodeficiency virus type 1 assembly in murine cells. J. Virol. 74 8 (2000) 3859-3870
30. Mariani R., Rasala B.A., Rutter G., Wiegers K., Brandt S.M., Krausslich H.G., and Landau N.R. Mouse-human heterokaryons support efficient human immunodeficiency virus type 1 assembly. J. Virol. 75 7 (2001) 3141-3151
31. McDonald D., Vodicka M.A., Lucero G., Svitkina T.M., Borisy G.G., Emerman M., and Hope T.J. Visualization of the intracellular behavior of HIV in living cells. J. Cell. Biol. 159 3 (2002) 441-452
32. Mitra D., Sikder S.K., and Laurence J. Role of glucocorticoid receptor binding sites in the human immunodeficiency virus type 1 long terminal repeat in steroid-mediated suppression of HIV gene expression. Virology 214 2 (1995) 512-521
33. Moore J.P., and Stevenson M. New targets for inhibitors of HIV-1 replication. Nat. Rev., Mol. Cell. Biol. 1 1 (2000) 40-49
34. Muthumani K., Choo A.Y., Zong W.X., Madesh M., Hwang D.S., Premkumar A., Thieu K.P., Emmanuel J., Kumar S., Thompson C.B., and Weiner D.B. The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat. Cell Biol. 8 2 (2006) 170-179
35. Mwaengo D.M., and Novembre F.J. Molecular cloning and characterization of viruses isolated from chimpanzees with pathogenic human immunodeficiency virus type 1 infections. J. Virol. 72 11 (1998) 8976-8987
36. Nitahara-Kasahara Y., Kamata M., Yamamoto T., Zhang X., Miyamoto Y., Muneta K., Iijima S., Yoneda Y., Tsunetsugu-Yokota Y., and Aida Y. Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages. J. Virol. 81 10 (2007) 5284-5293
37. Poindexter N.J., Walch E.T., Chada S., and Grimm E.A. Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells. J. Leukoc. Biol. 78 3 (2005) 745-752
38. Pomerantz R.J., Feinberg M.B., Trono D., and Baltimore D. Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. J. Exp. Med. 172 1 (1990) 253-261
39. Ray N., and Doms R.W. HIV-1 coreceptors and their inhibitors. Curr. Top. Microbiol. Immunol. 303 (2006) 97-120
40. Refaeli Y., Levy D.N., and Weiner D.B. The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product. Proc. Natl. Acad. Sci. U. S. A. 92 8 (1995) 3621-3625
41. Rosenberg Z.F., and Fauci A.S. Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression. Immunol. Today. 11 5 (1990) 176-180
42. Roser K., Bohn W., Giese G., and Mannweiler K. Subclones of C6 rat glioma cells differing in intermediate filament protein expression. Exp.Cell. Res. 197 2 (1991) 200-206
43. Sheehy A.M., Gaddis N.C., Choi J.D., and Malim M.H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418 6898 (2002) 646-650
44. Sheehy A.M., Gaddis N.C., and Malim M.H. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Nat. Med. 9 11 (2003) 1404-1407
45. Sherman M.P., de Noronha C.M., Pearce D., and Greene W.C. Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest. J. Virol. 74 17 (2000) 8159-8165
46. Sherman M.P., and Greene W.C. Slipping through the door: HIV entry into the nucleus. Microbes Infect. 4 1 (2002) 67-73
47. Sonza S., Maerz A., Deacon N., Meanger J., Mills J., and Crowe S. Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes. J. Virol. 70 6 (1996) 3863-3869
48. Soudeyns H., Geleziunas R., Shyamala G., Hiscott J., and Wainberg M.A. Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1. Virology 194 2 (1993) 758-768
49. Stevenson M., Stanwick T.L., Dempsey M.P., and Lamonica C.A. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9 5 (1990) 1551-1560
50. Thotala D., Schafer E.A., Tungaturthi P.K., Majumder B., Janket M.L., Wagner M., Srinivasan A., Watkins S., and Ayyavoo V. Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication. Virology 328 1 (2004) 89-100
51. Vanitharani R., Mahalingam S., Rafaeli Y., Singh S.P., Srinivasan A., Weiner D.B., and Ayyavoo V. HIV-1 Vpr transactivates LTR-directed expression through sequences present within -278 to -176 and increases virus replication in vitro. Virology 289 2 (2001) 334-342
52. Vazquez N., Greenwell-Wild T., Marinos N.J., Swaim W.D., Nares S., Ott D.E., Schubert U., Henklein P., Orenstein J.M., Sporn M.B., and Wahl S.M. Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. J. Virol. 79 7 (2005) 4479-4491
53. Vodicka M.A., Koepp D.M., Silver P.A., and Emerman M. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev. 12 2 (1998) 175-185
54. Wang L., Mukherjee S., Jia F., Narayan O., and Zhao L.J. Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat. J. Biol. Chem. 270 43 (1995) 25564-25569
55. Zack J.A., Arrigo S.J., Weitsman S.R., Go A.S., Haislip A., and Chen I.S. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61 2 (1990) 213-222
56. Zhou Y., Zhang H., Siliciano J.D., and Siliciano R.F. Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells. J. Virol. 79 4 (2005) 2199-2210