High-throughput determination of fudosteine in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 867, Issue 1, 2008, Pages 153-159

  Wen, Jun ^a,b,c   Wu, Yiwen ^a,b,c   Zhang, Linli ^a,b,c   Qi, Yunpeng ^a,b,c   Fan, Guorong ^a,b,c   Wu, Yutian ^a,b,c   Li, Zhen ^d  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c Shanghai Research Centre for Drug Chinese Materia Medica Metabolism   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

96 Well protein precipitation; Fudosteine; LC MS MS; Pharmacokinetics

Indexed keywords

IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS;

FUDOSTEINE; MULTIPLE REACTION MONITORING (MRM);

PROTEINS;

ERDOSTEINE; FORMIC ACID; FUDOSTEINE; METHANOL; PROTEIN; WATER;

ACCURACY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; HUMAN EXPERIMENT; IONIZATION; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PLASMA; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; VORTEX MOTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTINE; HUMANS; PRECIPITATION; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 42749093427     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.03.017     Document Type: Article

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