A Functional Polymorphism in THBS2 that Affects Alternative Splicing and MMP Binding Is Associated with Lumbar-Disc Herniation

American Journal of Human Genetics

Volumn 82, Issue 5, 2008, Pages 1122-1129

  Hirose, Yuichiro ^a,b   Chiba, Kazuhiro ^b   Karasugi, Tatsuki ^a,c   Nakajima, Masahiro ^a   Kawaguchi, Yoshiharu ^d   Mikami, Yasuo ^e   Furuichi, Tatsuya ^a   Mio, Futoshi ^a,b   Miyake, Atsushi ^a,b   Miyamoto, Takeshi ^b   Ozaki, Kouichi ^a   Takahashi, Atsushi ^a   Mizuta, Hiroshi ^c   Kubo, Toshikazu ^e   Kimura, Tomoatsu ^d   Tanaka, Toshihiro ^a   Toyama, Yoshiaki ^b   Ikegawa, Shiro ^a  

^a RIKEN   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TOYAMA   (Japan)

^e KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; POLYPYRIMIDINE TRACT BINDING PROTEIN;

ADULT; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; EXON; EXTRACELLULAR MATRIX; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; IN VIVO STUDY; INTRON; JAPANESE; LUMBAR DISK HERNIA; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; THBS2 GENE;

ADULT; ALTERNATIVE SPLICING; CELLS, CULTURED; EXTRACELLULAR MATRIX; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; THROMBOSPONDINS;

EID: 42749088826     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajhg.2008.03.013     Document Type: Article

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