Imaging the spread of reversible brain inactivations using fluorescent muscimol

Journal of Neuroscience Methods

Volumn 171, Issue 1, 2008, Pages 30-38

  Allen, Timothy A ^a   Narayanan, Nandakumar S ^a,c   Kholodar Smith, Dianna B ^a   Zhao, Yanjun ^a   Laubach, Mark ^b,c   Brown, Thomas H ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHN B PIERCE LABORATORY   (United States)

Author keywords

Amygdala; Fear conditioning; GABAA agonist; Lesions; Prefrontal cortex

Indexed keywords

MUSCIMOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; FLUORESCENCE; HISTOPATHOLOGY; IN VIVO STUDY; NEUROIMAGING; NEUROPHYSIOLOGY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SYNAPSE;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BRAIN; BRAIN MAPPING; CONDITIONING (PSYCHOLOGY); DIAGNOSTIC IMAGING; EXCITATORY POSTSYNAPTIC POTENTIALS; FEAR; FLUORESCENT DYES; GABA AGONISTS; MALE; MUSCIMOL; NEURAL INHIBITION; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME;

EID: 42749088311     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2008.01.033     Document Type: Article

References (31)

1. Allen T.A., Furtak S.C., and Brown T.H. Single-unit responses to 22 kHz ultrasonic vocalizations in rat perirhinal cortex. Behav Brain Res 182 2 (2007) 327-336
2. Arikan R., Blake N.M.J., Erinjeri J.P., Woolsey T.A., Giraud L., and Highstein S.M. A method to measure the effective spread of focally injected muscimol into the central nervous system with electrophysiology and light microscopy. J Neurosci Methods 118 (2002) 51-57
3. Anderson J.W. The production of ultrasonic sounds by laboratory rats and other mammals. Science 19 (1954) 808-809
4. Beaumont K., Chilton W.S., Yamamura H.I., and Enna S.J. Muscimol binding in rat brain: association with synaptic GABA receptors. Brain Res 148 (1978) 153-162
5. Blanchard R.J., and Blanchard D.C. Crouching as an index of fear. J Comp Physiol Psychol 67 (1969) 370-375
6. Brudzynski S.M. Ultrasonic calls of rats as indicator variables of negative or positive states. Acetylcholine-dopamine interaction and acoustic coding. Behav Brain Res 182 2 (2007) 261-273
7. Cohen J. Statistical power analysis for the behavioral sciences (1988), Academic Press, New York
8. Edeline J.-M., Hars B., Hennevin E., and Cotillon N. Muscimol diffusion after intracerebral microinjections: a reevaluation based on electrophysiological and autoradiographic quantifications. Neurobiol Learn Memory 78 (2002) 100-124
9. Faulkner B., and Brown T.H. Morphology and physiology of neurons in the rat perirhinal-lateral amygdala area. J Comp Neurol 411 (1999) 613-642
10. Furtak S.C., Allen T.A., and Brown T.H. Single-unit firing in rat perirhinal cortex caused by fear conditioning to arbitrary and ecological stimuli. J Neurosci 27 45 (2007) 12277-12291
11. Helmstetter F.J., and Bellgowan P.S. Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats. Behav Neurosci 108 (1994) 1005-1009
12. Hikosaka O., and Wurtz R.H. Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculline in monkey superior colliculus. J Neurophysiol 53 (1985) 266-291
13. Jarrard L.E. Use of excitotoxic lesion to the hippocampus: update. Hippocampus 12 3 (2002) 405-414
14. Krupa D.J., and Thompson R. Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response. Learn Memory 3 6 (1997) 545-556
15. Krupa D.J., Ghazanfar A.A., and Nicolelis M. Immediate thalamic sensory plasticity depends on corticothalamic feedback. Proc Natl Acad Sci 96 (2004) 8200-8205
16. LeDoux J.E. Emotion circuits in the brain. Annu Rev Neurosci 23 (2000) 155-184
17. Lindquist D.H., Jarrard L.E., and Brown T.H. Perirhinal cortex supports delay fear conditioning to rat ultrasonic social signals. J Neurosci 24 14 (2004) 3610-3617
18. Lomber S.G. The advantages and limitations of permanent or reversible deactivation techniques in the assessment of neural function. J Neurosci Methods 86 (1999) 109-117
19. Majchrzak M., and Di Scala G. GABA and muscimol as reversible inactivation tools in learning and memory. Neural Plast 7 (2000) 19-29
20. Maren S. Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24 (2001) 897-931
21. Martin J.H. Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat. Neurosci Lett 127 (1991) 160-164
22. Martin J.H., and Ghez C. Pharmacological inactivation in the analysis of the central control of movement. J Neurosci Methods 86 (1999) 145-159
23. Moyer J.R., and Brown T.H. Methods for whole-cell recording from visually preselected neurons of perirhinal cortex in brain slices from young and aging rats. J Neurosci Methods 86 1 (1998) 35-54
24. Moyer J.R., and Brown T.H. Patch-clamp techniques applied to brain slices. In: Walz W., and Baker G.B. (Eds). Patch-clamp analysis: advanced techniques vol. 35 (2002), Humana Press Inc., Totowa, NJ 135-193
25. Moyer J.R., and Brown T.H. Visually guided patch-clamp recordings in brain slices. In: Walz W., and Baker G.B. (Eds). Patch-clamp analysis: advanced techniques. 3rd ed. vol. 38 (2007), Humana Press Inc., Totowa, NJ 169-227
26. Muller J., Corodimas K.P., Fridel Z., and LeDoux J.E. Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli. Behav Neurosci 111 (1997) 683-691
27. Narayanan N.S., and Laubach M. Top-down control of motor cortex ensembles by dorsomedial prefrontal cortex. Neuron 52 (2006) 921-931
28. Narayanan N.S., Horst N.K., and Laubach M. Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus. Neuroscience 139 3 (2006) 865-876
29. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 3rd ed. (1998), Academic Press, San Diego
30. Wilensky A.E., Schafe G.E., and LeDoux J.E. Functional inactivation of the amygdala before but not after auditory fear conditioning prevents memory formation. J Neurosci 19 24 (1999) RC48
31. Wilensky A.E., Schafe G.E., Kristensen M.P., and LeDoux J.E. Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation and expression of Pavlovian fear conditioning. J Neurosci 26 48 (2006) 12387-12396