Serum D-Dimer is a Sensitive Test for the Detection of Acute Aortic Dissection: A Pooled Meta-Analysis

Journal of Emergency Medicine

Volumn 34, Issue 4, 2008, Pages 367-376

  Marill, Keith A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

acute; aorta; D dimer; dissection; sensitivity

Indexed keywords

D DIMER;

ACUTE DISEASE; AORTA DISSECTION; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; HUMAN; INFORMATION PROCESSING; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY;

ACUTE DISEASE; ANEURYSM, DISSECTING; AORTIC DISEASES; BIOLOGICAL MARKERS; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; SENSITIVITY AND SPECIFICITY;

EID: 42749087412     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2007.06.030     Document Type: Article

References (44)

1. Meszaros I., Morocz J., Szlavi J., et al. Epidemiology and clinicopathology of aortic dissection. A population-based longitudinal study over 27 years. Chest 117 (2000) 1271-1278
2. Klompas M. Does this patient have an acute thoracic aortic dissection?. JAMA 287 (2002) 2262-2272
3. Sullivan P.R., Wolfson A.B., Leckey R.D., and Burke J.L. Diagnosis of acute thoracic aortic dissection in the emergency department. Am J Emerg Med 18 (2000) 46-50
4. von Kodolitsch Y., Nienaber C.A., Dieckmann C., et al. Chest radiography for the diagnosis of acute aortic syndrome. Am J Med 116 2 (2004) 73-77
5. Moriyama Y., Toyohira H., Koga M., et al. Influence of aortic dissection on the clotting-fibrinolysis system and platelet function. Int J Angiol 7 (1998) 65-67
6. Weber T., Hogler S., Auer J., et al. D-dimer in acute aortic dissection. Chest 123 (2003) 1375-1378
7. Eggebrecht H., Naber C.K., Bruch C., et al. Value of plasma fibrin D-dimers for detection of acute aortic dissection. J Am Coll Cardiol 44 (2004) 804-809
8. Perez A., Abbet P., and Drescher M.J. D-dimers in the emergency department evaluation of aortic dissection. Acad Emerg Med 11 (2004) 397-400
9. Hazui H., Fukumoto H., Negoro N., et al. Simple and useful tests for discriminating between acute aortic dissection of the ascending aorta and acute myocardial infarction in the emergency setting. Circ J 69 (2005) 677-682
10. Akutsu K., Sato N., Yamamoto T., et al. A rapid bedside D-dimer assay (cardiac D-dimer) for screening of clinically suspected acute aortic dissection. Circ J 69 (2005) 397-403
11. Ohlmann P., Faure A., Petit H., et al. Diagnostic and prognostic value of circulating D-dimers in patients with acute aortic dissection. Crit Care Med 34 (2006) 1358-1364
12. Weber T., Rammer M., Auer J., Maurer E., Aspock G., and Eber B. Plasma concentrations of D-dimer predict mortality in acute type A aortic dissection. Heart 92 (2006) 836-837
13. Hazui H., Nishimoto M., Hoshiga M., et al. Young adult patients with short dissection length and thrombosed false lumen without ulcer-like projections are liable to have false-negative results of D-dimer testing for acute aortic dissection based on a study of 113 cases. Circ J 70 (2006) 1598-1601
14. Monaco M., Di Tommaso L., Stassano P., et al. Impact of blood coagulation and fibrinolytic system changes on early and mid term clinical outcome in patients undergoing stent endografting surgery. Interact Cardiovasc Thorac Surg 5 (2006) 724-728
15. Sbarouni E., Georgiadou P., Marathias A., Geroulanos S., and Kremastinos D.T. D-dimer and BNP levels in acute aortic dissection. Int J Cardiol 122 (2007) 170-172
16. Bossuyt P.M., Reitsma J.B., Bruns D.E., et al. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ 326 (2003) 41-44
17. Bossuyt P.M., Reitsma J.B., Bruns D.E., et al. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem 49 (2003) 7-18
18. Stroup D.F., Berlin J.A., Morton S.C., et al. Meta-analysis of observational studies in epidemiology. JAMA 283 (2000) 2008-2012
19. Whiting P., Rutjes A.W., Reitsma J.B., Bossuyt P.M., and Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3 (2003) 25
20. Hagan P.G., Nienaber C.A., Isselbacher E.M., et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 283 (2000) 897-903
21. Zamora J., Muriel A., and Abraira V. Meta-DiSc for Windows: a software package for the meta-analysis of diagnostic tests. XI Cochrane Colloquium. Barcelona, 2003. http://www.hrc.es/investigacion/metadisc.html Accessed May 28, 2006
22. Deeks J.J. Systematic reviews of evaluations of diagnostic and screening tests. In: Egger M., Davy Smith G., and Altman D.G. (Eds). Systematic reviews in health care: meta-analysis in context, 2nd edn (2001), BMJ Books, London, UK 248-282
23. Deeks J.J. Systematic reviews of evaluations of diagnostic and screening tests. BMJ 323 (2001) 157-162
24. Berlin J.A., Laird N.M., Sacks H.S., and Chalmers T.C. A comparison of statistical methods for combining event rates from clinical trials. Stat Med 8 (1989) 141-151
25. Ingelfinger J.A., Mosteller F., Thibodeau L.A., and Ware J.H. Using meta-analysis for research synthesis: pooling data from several studies. Biostatistics in clinical medicine. 3rd edn. (1994), McGraw-Hill, New York 340
26. D'Aloia A., Faggiano P., Brentana L., and Dei Cas L. D-dimer levels in a case of type B aortic dissection. A rapid test for the early diagnosis of acute aortic disease?. J Cardiovasc Med (Hagerstown) 7 (2006) 216-218
27. Donovan E.M., Seidel G.K., and Cohen A. Painless aortic dissection presenting as high paraplegia: a case report. Arch Phys Med Rehabil 81 (2000) 1436-1438
28. Lay C.-S., Yu C.-J., and Tyan Y.-S. Abdominal aortic dissection with acute mesenteric ischemia in a patient with Marfan syndrome. J Chin Med Assoc 69 (2006) 326-329
29. Kiernan T.J. Aortic dissection and elevated D-dimers-an important clinical link. Int J Cardiol 114 (2007) E77-E78
30. Flanagan L., Bancroft R., and Rittoo D. The value of d-dimer in the diagnosis of acute aortic dissection. Int J Cardiol 118 (2007) e70-e71
31. Iyano K., Kawada T., Aiba M., and Takaba T. Correlation of hemostatic markers and morphology of the residual false lumen in chronic aortic dissection. Ann Thorac Cardiovasc Surg 10 (2004) 106-112
32. Shimazaki T., Ishimaru S., Kawaguchi S., Yokoi Y., and Watanabe Y. Blood coagulation and fibrinolytic response after endovascular stent grafting of thoracic aorta. J Vasc Surg 37 (2006) 1213-1218
33. Gando S., Kameue T., Sawamura A., Hayakawa M., Hoshino H., and Kubota N. An alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass surgery and major abdominal surgery. Thromb Res 120 (2007) 87-93
34. Song F., Khan K.S., Dinnes J., and Sutton A.J. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol 31 (2002) 88-95
35. Iannelli G., Piscione F., DiTommaso L., Monaco M., Chiariello M., and Spampinato N. Thoracic aortic emergencies: impact of endovascular surgery. Ann Thorac Surg 77 (2004) 591-596
36. Suzuki T., Katoh H., Tsuchio Y., et al. Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection. Ann Intern Med 133 (2000) 537-541
37. Shinohara T., Suzuki K., Okada M., et al. Soluble elastin fragments in serum are elevated in acute aortic dissection. Arterioscler Thromb Vasc Biol 23 (2003) 1839-1844
38. Wells P.S., Anderson D.R., Rodger M., et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med 135 (2001) 98-107
39. von Kodolitsch Y., Schwart A.G., and Nienaber C.A. Clinical prediction of acute aortic dissection. Arch Intern Med 160 (2000) 2977-2982
40. Kabrhel C., Matts C., McNamara M., Katz J., and Ptak T. A highly sensitive ELISA D-dimer increases testing but not diagnosis of pulmonary embolism. Acad Emerg Med 13 (2006) 519-542
41. Wiegand J., Koller M., and Bingisser R. Does a negative D-dimer test rule out aortic dissection?. Swiss Med Wkly 137 (2007) 462
42. Lijmer J.G., Mol B.W., Heisterkamp S., et al. Empirical evidence of design-related bias in studies of diagnostic tests. JAMA 282 (1999) 1061-1066
43. Stein P.D., Hull R.D., Patel K.C., et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism. Ann Intern Med 140 (2004) 589-602
44. Brown M.D., Lau J., Nelson R.D., and Kline J.A. Turbidimetric D-dimer test in the diagnosis of pulmonary embolism: a metaanalysis. Clin Chem 49 (2003) 1846-1853