Evaluation of subchronic toxicity of dietary administered Cry1Ab protein from Bacillus thuringiensis var. Kurustaki HD-1 in F344 male rats with chemically induced gastrointestinal impairment

Food and Chemical Toxicology

Volumn 46, Issue 6, 2008, Pages 2184-2189

  Onose, Jun ichi ^a,b   Imai, Toshio ^a   Hasumura, Mai ^a   Ueda, Makoto ^a   Ozeki, Yoshihiro ^c   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

A gastrointestinal impairment rat model; Bacillus thuringiensis protein; Subchronic toxicity

Indexed keywords

CRY1AB TOXIN; FAMOTIDINE; INDOMETACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; BACILLUS THURINGIENSIS; BLOOD SAMPLING; CONTROLLED STUDY; DIET RESTRICTION; DIGESTIVE SYSTEM FUNCTION DISORDER; EUTHANASIA; INTESTINE INJURY; MALE; NONHUMAN; RAT; STOMACH ACID SECRETION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; BACILLUS THURINGIENSIS; BACTERIAL PROTEINS; DIET; EATING; ENDOTOXINS; FAMOTIDINE; GASTRIC ACID; GASTROINTESTINAL DISEASES; HEMOLYSIN PROTEINS; INDOMETHACIN; MALE; ORGAN SIZE; RATS; RATS, INBRED F344; WEIGHT GAIN;

ANIMALIA; BACILLUS THURINGIENSIS; RATTUS;

EID: 42749086296     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.02.015     Document Type: Article

References (26)

1. Astwood J.D., Leach J.N., and Fuchs R.L. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 14 (1996) 1269-1273
2. Betz F.S., Hammond B.G., and Fuchs R.L. Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests. Regul. Toxicol. Pharmacol. 32 (2000) 156-173
3. Carozzi N.B., Kramer V.C., Warren G.W., Evola S., and Koziel M.G. Prediction of insecticidal activity of Bacillus thuringiensis strains by polymerase chain reaction product profiles. Appl. Environ. Microbiol. 57 (1991) 3057-3061
4. Chowdhury E.H., Kuribara H., Hino A., Sultana P., Mikami O., Shimada N., Guruge K.S., Saito M., and Nakajima Y. Detection of corn intrinsic and recombinant DNA fragments and Cry1Ab protein in the gastrointestinal contents of pigs fed genetically modified corn Bt11. J. Anim. Sci. 81 (2003) 2546-2551
5. Chowdhury E.H., Shimada N., Murata H., Mikami O., Sultana P., Miyazaki S., Yoshioka M., Yamanaka N., Hirai N., and Nakajima Y. Detection of Cry1Ab protein in gastrointestinal contents but not visceral organs of genetically modified Bt11-fed calves. Vet. Hum. Toxicol. 45 (2003) 72-75
6. Dutta P., Smith R.D., and Flynn M.A. Effects of medroxyprogesterone acetate and caloric restriction on the distribution of serum and liver lipids and proteins in female rats. J. Nutr. 111 (1981) 1380-1389
7. Goodman N.S., Gottfried R.J., and Rogoff M.H. Biphasic system for separation of spores and crystals of Bacillus thuringiensis. J. Bacteriol. 94 (1967) 485
8. Imai T., Onose J., Hasumura M., Takizawa T., and Hirose M. Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine. Toxicol. Lett. 164 (2006) 71-80
9. Knudsen I., and Poulsen M. Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event. Regul. Toxicol. Pharmacol. 49 (2007) 52-62
10. Konig A., Cockburn A., Crevel R.W., Debruyne E., Grafstroem R., Hammerling U., Kimber I., Knudsen I., Kuiper H.A., Peijnenburg A.A., Penninks A.H., Poulsen M., Schauzu M., and Wal J.M. Assessment of the safety of foods derived from genetically modified (GM) crops. Food Chem. Toxicol. 42 (2004) 1047-1088
11. Krieglstein C.F., Salter J.W., Cerwinka W.H., Russell J.M., Schuermann G., Bruewer M., Laroux F.S., Grisham M.B., and Granger D.N. Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis. Biochem. Biophys. Res. Commun. 282 (2001) 635-642
12. Krugliak P., Hollander D., Le K., Ma T., Dadufalza V.D., and Katz K.D. Regulation of polyethylene glycol 400 intestinal permeability by endogenous and exogenous prostanoids. Influence of non-steroidal anti-inflammatory drugs. Gut 31 (1990) 417-421
13. Kuiper H.A., Noteborn H.P., and Peijnenburg A.A. Adequacy of methods for testing the safety of genetically modified foods. Lancet 354 (1999) 1315-1316
14. Linskens R.K., Huijsdens X.W., Savelkoul P.H., Vandenbroucke-Grauls C.M., and Meuwissen S.G. The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics. Scand. J. Gastroenterol. 234 Suppl. (2001) 29-40
15. MacFarlane A.J., Burghardt K.M., Kelly J., Simell T., Simell O., Altosaar I., and Scott F.W. A type 1 diabetes-related protein from wheat (Triticum aestivum) cDNA clone of a wheat storage globulin, Glb1, linked to islet damage. J. Biol. Chem. 278 (2003) 54-63
16. Miwa M., Tani N., and Miwa T. Inhibition of gastric secretion by a new H2-antagonist, YM-11170 in healthy subjects. Int. J. Clin. Pharmacol. Ther. Toxicol. 22 (1984) 214-217
17. Sartori S., Trevisani L., Nielsen I., Tassinari D., Panzini I., and Abbasciano V. Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury. J. Clin. Oncol. 18 (2000) 463-467
18. Schnepf H.E., and Whiteley H.R. Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli. Proc. Natl. Acad. Sci. USA. 78 (1981) 2893-2897
19. Seager J.M., and Hawkey C.J. ABC of the upper gastrointestinal tract: Indigestion and non-steroidal anti-inflammatory drugs. BMJ 323 (2001) 1236-1239
20. Shay H. Importance of appraising the true gastric acidity after subtotal gastrectomy. J. Am. Med. Assoc. 155 (1954) 1131-1133
21. Smith G.S., Hall R.L., and Walker R.M. Applied clinical pathology in preclinical toxicology testing. In: Haschek W.M., Rousseaux C.G., and Wallig M.A. (Eds). Handbook of Toxicologic Pathology vol. 1 (2002), Academic press, San Diego 123-156
22. Soderholm J.D., Peterson K.H., Olaison G., Franzen L.E., Westrom B., Magnusson K.E., and Sjodahl R. Epithelial permeability to proteins in the noninflammed ileum of Crohn's disease?. Gastroenterology 117 (1999) 65-72
23. Thomas W.E., and Ellar D.J. Bacillus thuringiensis var israelensis crystal delta-endotoxin: effects on insect and mammalian cells in vitro and in vivo. J. Cell Sci. 60 (1983) 181-197
24. Vaeck M., Reybnaerts A., Hofte J., Jansens S., DeBeuckeleer M., Dean C., Zabeau M., Van Montagu M., and Leemans J. Transgenic plants protected from insect attack. Nature 328 (1987) 33-37
25. Van Niel G., Mallegol J., Bevilacqua C., Candalh C., Brugière S., Tomaskovic-Crook E., Heath J.K., Cerf-Bensussan N., and Heyman M. Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice. Gut 52 (2003) 1690-1697
26. Waner T., Nyska A., and Chen R. Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex. Lab Anim. 25 (1991) 263-271