Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping

Experimental Neurology

Volumn 211, Issue 1, 2008, Pages 25-33

  Vogt, M A ^a   Chourbaji, S ^a   Brandwein, C ^a   Dormann, C ^a   Sprengel, R ^b   Gass, P ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Anxiety; Behavior; Depression; Inducible mutagenesis; Learning; Memory; Mice; Psychiatry; Tamoxifen

Indexed keywords

TAMOXIFEN;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; CONDITIONING; DEPRESSION; EXPLORATORY BEHAVIOR; LEARNING; LOCOMOTION; MALE; MAZE TEST; MEMORY; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BODY WEIGHT; CONDITIONING (PSYCHOLOGY); ESTROGEN ANTAGONISTS; EXPLORATORY BEHAVIOR; FEAR; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MUTAGENESIS; PHENOTYPE; REACTION TIME; SWIMMING; TAMOXIFEN;

EID: 42749085298     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.12.012     Document Type: Article

References (33)

1. Balschun D., Wolfer D.P., Gass P., Mantamadiotis T., Welzl H., Schutz G., Frey J.U., and Lipp H.P. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?. J. Neurosci. 23 (2003) 6304-6314
2. Chen D., Wu C.F., Shi B., and Xu Y.M. Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice. Pharmacol. Biochem. Behav. 72 (2002) 417-421
3. Chen D., Wu C.F., Shi B., and Xu Y.M. Tamoxifen and toremifene cause impairment of learning and memory function in mice. Pharmacol. Biochem. Behav. 71 (2002) 269-276
4. Chourbaji S., Urani A., Inta I., Sanchis-Segura C., Brandwein C., Zink M., Schwaninger M., and Gass P. IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors. Neurobiol. Dis. 23 (2006) 587-594
5. Chourbaji S., Zacher C., Sanchis-Segura C., Dormann C., Vollmayr B., and Gass P. Learned helplessness: validity and reliability of depressive-like states in mice. Brain Res. Brain Res. Protoc. 16 (2005) 70-78
6. Cryan J.F., and Holmes A. The ascent of mouse: advances in modelling human depression and anxiety. Nat. Rev. Drug Discov. 4 (2005) 775-790
7. Csaba G., Karabelyos C., and Inczefi-Gonda A. Effect of tamoxifen treatment at adolescent age on the sexual behaviour and steroid hormone receptor binding of adult female rats. Acta Physiol. Hung. 88 (2001) 131-137
8. Erdmann G., Schutz G., and Berger S. Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci. 8 (2007) 63
9. Feil R., Wagner J., Metzger D., and Chambon P. Regulation of Cre-recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem. Biophys. Res. Commun. 237 (1997) 752-757
10. Fleischmann A., Hvalby O., Jensen V., Strekalova T., Zacher C., Layer L.E., Kvello A., Reschke M., Spanagel R., Sprengel R., Wagner E.F., and Gass P. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J. Neurosci. 23 (2003) 9116-9122
11. Ganat Y.M., Silbereis J., Cave C., Ngu H., Anderson G.M., Ohkubo Y., Ment L.R., and Vaccarino F.M. Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo. J. Neurosci. 26 (2006) 8609-8621
12. Gass P., Wolfer D.P., Balschun D., Rudolph D., Frey U., Lipp H.P., and Schutz G. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn. Mem. 5 (1998) 274-288
13. Hirrlinger P.G., Scheller A., Braun C., Hirrlinger J., and Kirchhoff F. Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia. 54 (2006) 11-20
14. Imwalle D.B., Gustafsson J.A., and Rissman E.F. Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol. Behav. 84 (2005) 157-163
15. Krezel W., Dupont S., Krust A., Chambon P., and Chapman P.F. Increased anxiety and synaptic plasticity in estrogen receptor beta-deficient mice. Proc. Natl. Acad. Sci. U S A. 98 (2001) 12278-12282
16. Leone D.P., Genoud S., Atanasoski S., Grausenburger R., Berger P., Metzger D., Macklin W.B., Chambon P., and Suter U. Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol. Cell Neurosci. 22 (2003) 430-440
17. Lund T.D., Rovis T., Chung W.C., and Handa R.J. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology. 146 (2005) 797-807
18. Malleret G., Haditsch U., Genoux D., Jones M.W., Bliss T.V., Vanhoose A.M., Weitlauf C., Kandel E.R., Winder D.G., and Mansuy I.M. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell. 104 (2001) 675-686
19. Mansuy I.M., and Bujard H. Tetracycline-regulated gene expression in the brain. Curr. Opin. Neurobiol. 10 (2000) 593-596
20. Mayford M., Bach M.E., Huang Y.Y., Wang L., Hawkins R.D., and Kandel E.R. Control of memory formation through regulated expression of a CaMKII transgene. Science. 274 (1996) 1678-1683
21. McIlwain K.L., Merriweather M.Y., Yuva-Paylor L.A., and Paylor R. The use of behavioral test batteries: effects of training history. Physiol. Behav. 73 (2001) 705-717
22. Mori T., Tanaka K., Buffo A., Wurst W., Kuhn R., and Gotz M. Inducible gene deletion in astroglia and radial glia-a valuable tool for functional and lineage analysis. Glia. 54 (2006) 21-34
23. Morozov A., Kellendonk C., Simpson E., and Tronche F. Using conditional mutagenesis to study the brain. Biol. Psychiatry. 54 (2003) 1125-1133
24. Ridder S., Chourbaji S., Hellweg R., Urani A., Zacher C., Schmid W., Zink M., Hortnagl H., Flor H., Henn F.A., Schutz G., and Gass P. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci. 25 (2005) 6243-6250
25. Schonig K., and Bujard H. Generating conditional mouse mutants via tetracycline-controlled gene expression. Methods Mol. Biol. 209 (2003) 69-104
26. van Gaalen M.M., and Steckler T. Behavioural analysis of four mouse strains in an anxiety test battery. Behav. Brain Res. 115 (2000) 95-106
27. Walf A.A., Rhodes M.E., and Frye C.A. Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test. Pharmacol. Biochem. Behav. 78 (2004) 523-529
28. Walf A.A., and Frye C.A. ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology. 30 (2005) 1598-1609
29. Walf A.A., and Frye C.A. A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior. Neuropsychopharmacology. 31 (2006) 1097-1111
30. Walf A.A., Ciriza I., Garcia-Segura L.M., and Frye C.A. Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol's modulation of affective and sexual behavior, respectively. Neuropsychopharmacology (2007) 10.1038/sj.npp.1301416
31. Wolfer D.P., Muller U., Stagliar M., and Lipp H.P. Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified beta-amyloid precursor protein gene. Brain Res. 771 (1997) 1-13
32. Zörner B., Wolfer D.P., Brandis D., Kretz O., Zacher C., Madani R., Grunwald I., Lipp H.P., Klein R., Henn F.A., and Gass P. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than depressive. Biol. Psychiatry. 54 (2003) 972-982
33. Zueger M., Urani A., Chourbaji S., Zacher C., Roche M., Harkin A., and Gass P. Olfactory bulbectomy in mice induces alterations in exploratory behavior. Neurosci. Lett. 374 (2005) 142-146