Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells

Archives of Histology and Cytology

Volumn 70, Issue 5, 2007, Pages 303-312

  Hida, Tatsuhiro ^a   Ikeda, Hiroko ^b   Kametaka, Satoshi ^b   Akazawa, Chihiro ^c,d   Kohsaka, Shinichi ^c   Ebisu, Shigeyuki ^a   Uchiyama, Yasuo ^a   Waguri, Satoshi ^b  

^a OSAKA UNIVERSITY   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CATHEPSIN D; GOLGI LOCALIZED GAMMA EAR CONTAINING ADP RIBOSYLATION FACTOR 1; GOLGI LOCALIZED GAMMA EAR CONTAINING ADP RIBOSYLATION FACTOR 2; GOLGI LOCALIZED GAMMA EAR CONTAINING ADP RIBOSYLATION FACTOR 3; LYSOSOME ENZYME; SOMATOMEDIN B RECEPTOR;

ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME RELEASE; HELA CELL; HUMAN; HUMAN CELL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANS GOLGI NETWORK;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADP-RIBOSYLATION FACTORS; AMINO ACID MOTIFS; CATHEPSIN D; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; RECEPTOR, IGF TYPE 2; RNA INTERFERENCE;

EID: 42649130044     PISSN: 09149465     EISSN: 13491717     Source Type: Journal    
DOI: 10.1679/aohc.70.303     Document Type: Article

References (28)

1. Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O: ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization. Mol Biol Cell 13: 3078-3095 (2002).
2. Bonifacino JS: The GGA proteins: adaptors on the move. Nat Rev Mol Cell Biol 5: 23-32 (2004).
3. Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS: GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol 149: 81-94 (2000).
4. Doray B, Bruns K, Ghosh P, Kornfeld SA: Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc Natl Acad Sci USA 99: 8072-8077 (2002a).
5. Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S: Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science 297: 1700-1703 (2002b).
6. Ghosh P, Kornfeld S: Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem 278: 14543-14549 (2003).
7. Ghosh P, Kornfeld S: The GGA proteins: key players in protein sorting at the trans-Golgi network. Eur J Cell Biol 83: 257-262 (2004).
8. Ghosh P, Griffith J, Geuze HJ, Kornfeld S: Mammalian GGAs act together to sort mannose 6-phosphate receptors. J Cell Biol 163: 755-766 (2003).
9. Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS: A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. J Cell Biol 149: 67-80 (2000).
10. Kametaka S, Mattera R, Bonifacino JS: Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes. Mol Cell Biol 25: 7988-8000 (2005).
11. Lui WW, Collins BM, Hirst J, Motley A, Millar C, Schu P, Owen DJ, Robinson MS: Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Mol Biol Cell 14: 2385-2398 (2003).
12. Mardones GA, Burgos PV, Brooks DA, Parkinson-Lawrence E, Mattera R, Bonifacino JS: The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting. Mol Biol Cell 18: 3486-3501 (2007).
13. Mattera R, Aright CN, Lodge R, Zerial M, Bonifacino JS: Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. EMBO J 22: 78-88 (2003).
14. Meyer C, Eskelinen EL, Guruprasad MR, von Figura K, Schu P: Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate. J Cell Sci 114: 4469-4476 (2001).
15. Meyer C, Zizioli D, Lausmann S, Eskelinen EL, Hamann J, Saftig P, von Figura K, Schu P: mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J 19: 2193-2203 (2000).
16. Muno D, Ishidoh K, Ueno T, Kominami E: Processing and transport of the precursor of cathepsin C during its transfer into lysosomes. Arch Biochem Biophys 306: 103-110 (1993).
17. Puertollano R, Bonifacino JS: Interactions of GGA3 with the ubiquitin sorting machinery. Nat Cell Biol 6: 244-251 (2004).
18. Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS: Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science 292: 1712-1716 (2001).
19. Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS: The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell 105: 93-102 (2001).
20. Scott PM, Bilodeau PS, Zhdankina O, Winistorfer SC, Hauglund MJ, Allaman MM, Kearney WR, Robertson AD, Boman AL, Piper RC: GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network. Nat Cell Biol 6: 252-259 (2004).
21. Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K: GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination. J Biol Chem 279: 7105-7111 (2004).
22. Takatsu H, Katoh Y, Shiba Y, Nakayama K: Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. J Biol Chem 276: 28541-28545 (2001).
23. Takatsu H, Yoshino K, Nakayama K: Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. Biochem Biophys Res Commun 271: 719-725 (2000).
24. Takatsu H, Yoshino K, Toda K, Nakayama K: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. Biochem J 365: 369-378 (2002).
25. Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y: Predominant expression of the short form of GGA3 in human cell lines and tissues. Biochem Biophys Res Commun 306: 687-692 (2003).
26. Yogosawa S, Kawasaki M, Wakatsuki S, Kominami E, Shiba Y, Nakayama K, Kohsaka S, Akazawa C: Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. Biochem Biophys Res Commun 350: 82-90 (2006).
27. Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC: Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. FEBS Lett 537: 171-176 (2003).
28. Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S: Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. Science 292: 1716-1718 (2001).