The cholinergic system and cancer

Seminars in Cancer Biology

Volumn 18, Issue 3, 2008, Pages 211-217

  Paleari, Laura ^a   Grozio, Alessia ^a   Cesario, Alfredo ^b,c   Russo, Patrizia ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Cell growth; Lung cancer; Neurotoxin; Non neuronal cholinergic system

Indexed keywords

ATROPINE; CARBACHOL; DEXETIMIDE; FORSKOLIN; LEVETIMIDE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINIC RECEPTOR; PIRENZEPINE; QUINUCLIDINYL BENZILATE;

ABSORPTION; AUTOCRINE EFFECT; CELL ACTIVITY; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL SECRETION; CELL TYPE; CHOLINERGIC SYSTEM; CILIARY MOTILITY; CYTOSKELETON; HUMAN; LUNG SMALL CELL CANCER; NONHUMAN; REVIEW; WATER ABSORPTION;

ANIMALS; EXOCYTOSIS; HUMANS; NEOPLASMS; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC;

EID: 42649126369     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2007.12.009     Document Type: Review

References (32)

1. Falugi C., Balza E., and Zardi L. Localization of acetylcholinesterase in normal human fibroblasts and in a human fibrosarcoma cell line. Basic Appl Histochem 27 (1983) 205-210
2. Falugi C., Castellani P., Raffanti S., Borsi L., and Zardi L. Acetylcholinesterase in normal and malignant human cells. Basic Appl Histochem 30 (1986) 433-446
3. Wessler I., Kilbinger H., Bittinger F., and Kirkpatrik C.J. The non-neuronal cholinergic system in humans: expression, function and pathophysiology. Life Sci 72 (2003) 2055-2061
4. Wessler I., Kirkpatrik C.J., and Racke K. Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol Ther 77 (1998) 59-79
5. Wessler I., Kirkpatrik C.J., and Racke K. The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol 26 (1999) 198-205
6. Wessler I., Kilbinger H., Bittinger F., and Kirkpatrik C.J. The biological role of non-neuronal acetylcholine in plants and humans. Jpn J Pharmacol 85 (2001) 2-10
7. Pfeil U., Lips K.S., Eberling L., Grau V., Haberberger R.V., and Kummer W. Expression of the high-affinity choline transporter, CHT1, in the rat trachea. Am J Respir Cell Mol Biol 28 (2003) 473-477
8. Pfeil U., Haberberger R.V., Lips K.S., Ederling L., Grau V., and Kummer W. Expression of the high-affinity choline transporter CHT1 in epithelia. Life Sci 72 (2003) 2087-2090
9. Maneckjee R., and Minna J.D. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci USA 8 (1990) 3294-3298
10. Cavallotti C., Tonnarini G., D'Andrea V., and Cavallotti D. Cholinergic staining of bronchus-associated lymphoid tissue. Neuroimmunomodulation 12 (2005) 141-145
11. Martínez-Moreno P., Nieto-Cerón S., Torres-Lanzas J., Ruiz-Espejo F., Tovar-Zapata I., Martínez-Hernández P., et al. Cholinesterase activity of human lung tumours varies according to their histological classification. Carcinogenesis 27 (2006) 429-436
12. Sargent P.B. The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16 (1993) 403-443
13. Lukas R.J., Changeux J.P., Le Novere N., Albuquerque E.X., Balfour D.J., Berg D.K., et al. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51 (1999) 397-401
14. Corringer P.J., Le Novere N., and Changeux J.P. Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol 40 (2000) 431-458
15. Hogg R.C., Buisson B., and Bertrand D. Allosteric modulation of ligand-gated ion channels. Biochem Pharmacol 1 70 (2005) 1267-1276
16. Bockaert J., and Pin J.P. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J 18 (1999) 1723-1729
17. Hamm H.E. The many faces of G protein signaling. J Biol Chem 273 (1998) 669-672
18. Caulfield M.P., and Birdsall N.J. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50 (1998) 279-290
19. Caulfield M.P. Muscarinic receptors-characterization, coupling and function. Pharmacol Ther 58 (1993) 319-379
20. Grozio A., Catassi A., Cavalieri Z., Paleari L., Cesario A., and Russo P. Nicotine, lung and cancer. Anticancer Agents Med Chem 7 (2007) 461-466
21. Russo P., Catassi A., Cesario A., and Servent D. Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system. Curr Med Chem 13 (2006) 3493-3512
22. Trombino S., Bisio A., Catassi A., Cesario A., Falugi C., and Russo P. Role of the non-neuronal human cholinergic system in lung cancer and mesothelioma: possibility of new therapeutic strategies. Curr Med Chem Anticancer Agents 4 (2004) 535-542
23. Accurso F.J. Update in cystic fibrosis 2005. Am J Respir Crit Care Med 173 (2006) 944-947
24. Andre C., Marullo S., Convents A., Lu B.Z., Guillet J.G., Hoebeke J., et al. A human embryonic lung fibroblast with a high density of muscarinic acetylcholine receptors. Eur J Biochem 171 (1988) 401-407
25. Haddad E.B., Rousell J., Mak J.C., and Barnes P.J. Long-term carbachol treatment-induced down-regulation of muscarinic M2-receptors but not m2 receptor mRNA in a human lung cell line. Br J Pharmacol 116 (1995) 2027-2032
26. Cunningham J.M., Lennon V.A., Lambert E.H., and Scheithauer B. Acetylcholine receptors in small cell carcinomas. J Neurochem 45 (1985) 159-167
27. Williams C.L., and Lennon V.A. Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. Cell Regul 2 (1991) 373-381
28. Williams C.L., Hayes V.Y., Hummel A.M., Tarara J.E., and Halsey T.J. Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma. J Cell Biol 121 (1993) 643-654
29. Williams C.L. Muscarinic signaling in carcinoma cells. Life Sci 72 (2003) 2173-2182
30. Ibanez-Tallon I., Miwa J.M., Wang H.L., Adams N.C., Crabtree G.W., Sine S.M., et al. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 33 (2002) 893-903
31. Calmette A., Sena A., and Costil L.C. Du venin de cobra sur les greffes canceréuses et sur le cancer spontané (adéno-carcinome) de la souris. R Acad Sci 197 (1933) 205
32. Song P., Sekhon H.S., Lu A., Arredondo J., Sauer D., Gravett C., et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res 67 (2007) 3936-3944