Hyperosmolarity attenuates the contraction of rat trachea through the inhibition of phosphatidylinositol response

Acta Medica Nagasakiensia

Volumn 52, Issue 4, 2007, Pages 107-110

  Saito, Masataka ^a   Shibata, Osamu ^a   Matsunaga, Shoji ^a   Tsuda, Atsushi ^a   Makita, Tetsuji ^a   Sumikawa, Koji ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Contractile and phosphatidylinositol (PI) responses; Hyperosmolarity; Rat trachea

Indexed keywords

ALUMINUM FLUORIDE; CARBACHOL; G PROTEIN COUPLED PHOSPHOLIPASE C INHIBITOR; GLUCOSE; HYPERTONIC SOLUTION; KREBS HENSELEIT SOLUTION; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL INHIBITOR; PHOSPHOLIPASE C INHIBITOR; PROSTAGLANDIN E2;

AIRWAY CONSTRICTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DOSE RESPONSE; HYPEROSMOLARITY; IN VITRO STUDY; MALE; MUSCLE CONTRACTILITY; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; RAT; TRACHEA MUSCLE;

EID: 42649119411     PISSN: 00016055     EISSN: 00016055     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Caplin I. Diabetes mellitus and insulin in an aspirin-sensitive asthmatic. Ann Allergy 36: 193-202, 1976
2. Douglas NJ, Campbell TW, Ewing DJ et al. Reduced airway vagal tone in diabetic subjects with autonomic neuropathy. Cli Sci 61: 581-584, 1981
3. Heaton RW. Diminished bronchial reactivity to cold air in diabetic patients with autonomic neuropathy Br Med J 289: 149, 1984
4. 2 muscarinic receptor in diabetic rat lung. Br J Pharmacol 121: 1287-1294, 1997
5. Jongejan RC, De Jongste JC, Raatgeep RC, et al. Effects of change in osmolarity on isolated human airways. J Appl Phisiol 64: 1568-1575, 1990
6. Meurs H, Roffel AF, Postema JB, Timmermans A. Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists. Eur J Pharmacol 156: 271-274, 1988
7. Sternweis PC, Gilman AG. Aluminium: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natla Acad Sci 79:4888-4891, 1982
8. Wood SF, Szuts EZ, Fein A. Inositol trisphosphate production in squid photoreceptor. Activation by light, aluminum fluoride, and guanine nucleotides. J Bio Chem 264: 12970-12976, 1989
9. Boucher RC. Human airway ion transport. Part two. Am J Respir Crit Care Med 150: 581-593, 1994
10. Morrison KJ, Gao Y, Vanhoutte PM. Epithelial modulation of airway smooth muscle. Am J Physiol 258: 254-262, 1990
11. Rocha G, Bucher B, Tschopl M, et al. Hyperosmolarity enhances smooth muscle contractile responses to phenylephrine and partially impairs nitric oxide production in the rat tail artery. J Vasc Res 32: 58-65, 1995
12. Munakata M, Mitzner W, Menkes HA et al. Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea. J Appl Physiol 64: 466-471, 1988
13. Munakata M, Masaki Y, Sakura I et al. Pharmacological differentiation of epithelium-derived relaxing factor from nitric oxide. J Appl Physiol 69: 665-670, 1990
14. Hjoberg J, Folkerts G, van Gessel SBE et al. Hyperosmolarity-induced relaxation and prostaglandin release in guinea pig trachea in vitro. Eur J Pharmacol 398: 303-307, 2000