Hyperosmolarity-induced relaxation and prostaglandin release in guinea pig trachea in vitro

European Journal of Pharmacology

Volumn 398, Issue 2, 2000, Pages 303-307

  Hjoberg, Josephine ^a   Folkerts, Gert ^b   Van Gessel, Sandra B E ^b   Högman, Marieann ^a   Hedenstierna, Göran ^a   Nijkamp, Frans P ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Guinea pig; Hyperosmolarity; Nitric oxide (NO); Prostaglandin; Tracheal perfusion; Vasoactive intestinal peptide (VIP)

Indexed keywords

INDOMETACIN; ISOPRENALINE; MEPACRINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; SODIUM CHLORIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST;

ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOSPASM; CONTROLLED STUDY; EXERCISE; GUINEA PIG; HYPEROSMOLARITY; MALE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS INHIBITION; SMOOTH MUSCLE RELAXATION; TRACHEA; TRACHEA MUCOSA;

ANIMALS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GUINEA PIGS; INDOMETHACIN; MALE; MUSCLE RELAXATION; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; OSMOLAR CONCENTRATION; PROSTAGLANDINS; QUINACRINE; SODIUM CHLORIDE; TRACHEA;

EID: 0034674661     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00289-2     Document Type: Article

References (25)

1. Anderson S.D. Asthma provoked by exercise, hyperventilation and the inhalation of non-isotonic aerosols. Barnes P.J., Rodger I.W., Thomson N.C. Asthma. Basic mechanisms and clinical management. 1998;569-587 Academic Press, San Diego, CA, USA.
2. Anderson S.D., Schoeffel R.E., Finney M. Evaluation of ultrasonically nebulised solutions for provocation testing in patients with asthma. Thorax. 38:1983;284-291.
3. Barnes P.J. NANC nerves and neuropeptides. Barnes P.J., Rodger I.W., Thomson N.C. Asthma. Basic mechanisms and clinical management. 1998;424-457 Academic Press, San Diego, CA, USA.
4. Belcher N.G., Rees P.J., Clark T.J., Lee T.H. A comparison of the refractory periods induced by hypertonic airway challenge and exercise in bronchial asthma. Am. Rev. Respir. Dis. 135:1987;822-825.
5. Boucher R.C. Human airway ion transport. Part two. Am. J. Respir. Crit. Care Med. 150:1994;581-593.
6. Churchill L., Chilton F.H., Resau J.H., Bascom R., Hubbard W.C., Proud D. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am. Rev. Respir. Dis. 140:1989;449-459.
7. 2 by bovine cultured airway smooth muscle cells and its inhibition by cyclooxygenase inhibitors. Br. J. Pharmacol. 111:1994;983-988.
8. Fedan J.S., Nutt M.E., Frazer D.G. Reactivity of guinea-pig isolated trachea to methacholine, histamine and isoproterenol applied serosally versus mucosally. Eur. J. Pharmacol. 190:1990;337-345.
9. Fedan J.S., Yuan L.X., Chang V.C., Viola J.O., Cutler D., Pettit L.L. Osmotic regulation of airway reactivity by epithelium. J. Pharmacol. Exp. Ther. 289:1999;901-910.
10. Folkerts G., Nijkamp F.P. Airway epithelium: more than just a barrier! Trends Pharmacol. Sci. 19:1998;334-341.
11. Folkerts G., van der Linde H., Verheyen A.K., Nijkamp F.P. Endogenous nitric oxide modulation of potassium-induced changes in guinea-pig airway tone. Br. J. Pharmacol. 115:1995;1194-1198.
12. Hawksworth R.J., O'Hickey S.P., Lee T.H. The effects of indomethacin on the refractory period to hypertonic saline-induced bronchoconstriction. Eur. Respir. J. 5:1992;963-966.
13. 2 alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes. Am. J. Respir. Crit. Care Med. 158:1998;1374-1378.
14. Margolskee D.J., Bigby B.G., Boushey H.A. Indomethacin blocks airway tolerance to repetitive exercise but not to eucapnic hyperpnea in asthmatic subjects. Am. Rev. Respir. Dis. 137:1988;842-846.
15. Menon N.K., Patricza J., Binder T., Bing R.J. Reduction of biological effluents in purge and trap micro reaction vessels and detection of endothelium-derived nitric oxide (edno) by chemiluminescence. J. Mol. Cell. Cardiol. 23:1991;389-393.
16. Munakata M., Mitzner W., Menkes H.A. Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea. J. Appl. Physiol. 64:1988;466-471.
17. Munakata M., Huang I., Mitzner W., Menkes H. Protective role of epithelium in the guinea pig airway. J. Appl. Physiol. 66:1989;1547-1552.
18. Munakata M., Masaki Y., Sakuma I., Ukita H., Otsuka Y., Homma Y., Kawakami Y. Pharmacological differentiation of epithelium-derived relaxing factor from nitric oxide. J. Appl. Physiol. 69:1990;665-670.
19. Noah T.L., Paradiso A.M., Madden M.C., McKinnon K.P., Devlin R.B. The response of a human bronchial epithelial cell line to histamine: intracellular calcium changes and extracellular release of inflammatory mediators. Am. J. Respir. Cell Mol. Biol. 5:1991;484-492.
20. Nogami H., Umeno E., Kano S., Hirose T., Nishima S. Effect of nitric oxide synthase inhibitor on allergen- and hyperventilation-induced bronchoconstriction in guinea-pigs. Eur. Respir. J. 12:1998;1318-1321.
21. O'Byrne P.M. Prostaglandins and thromboxane. Barnes P.J., Rodger I.W., Thomson N.C. Asthma. Basic mechanisms and clinical management. 1998;269-280 Academic Press, San Diego, CA, USA.
22. O'Byrne P.M., Jones G.L. The effect of indomethacin on exercise-induced bronchoconstriction and refractoriness after exercise. Am. Rev. Respir. Dis. 134:1986;69-72.
23. Pavlovic D., Fournier M., Aubier M., Pariente R. Epithelial vs. serosal stimulation of tracheal muscle: role of epithelium. J. Appl. Physiol. 67:1989;2522-2526.
24. 2) by cultured human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 1:1989;245-250.
25. Willumsen N.J., Davis C.W., Boucher R.C. Selective response of human airway epithelia to luminal but not serosal solution hypertonicity. Possible role for proximal airway epithelia as an osmolality transducer. J. Clin. Invest. 94:1994;779-787.