Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus

Virology

Volumn 374, Issue 2, 2008, Pages 249-255

  Růžek, Daniel ^a,b   Gritsun, Tamara S ^b,c   Forrester, Naomi L ^b,d   Gould, Ernest A ^b,e   Kopecký, Jan ^a,b   Golovchenko, Maryna ^a,b   Rudenko, Nataliia ^a,b   Grubhoffer, Libor ^a,b  

^a INSTITUTE OF PARASITOLOGY   (Czech Republic)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^c UNIVERSITY OF READING   (United Kingdom)

^d University of Texas Medical Branch School of Medicine   (United States)

^e CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

Author keywords

Neuroinvasiveness; Tick borne encephalitis virus; Viral protease

Indexed keywords

AMINO ACID; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PROTEINASE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; FEMALE; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; GENOME ANALYSIS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TEMPERATURE; TICK BORNE ENCEPHALITIS FLAVIVIRUS; UNINDEXED SEQUENCE; VIRUS ATTACHMENT; VIRUS CULTURE; VIRUS GENOME; VIRUS ISOLATION; VIRUS PARTICLE; VIRUS PLAQUE; VIRUS RESISTANCE; VIRUS STRAIN; VIRUS VIRULENCE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, SUCKLING; BASE SEQUENCE; BRAIN; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; EUROPE; FEMALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; MUTATION; RNA HELICASES; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; SERIAL PASSAGE; SERINE ENDOPEPTIDASES; TICKS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE;

IXODIDA; MAMMALIA; MUS; TICK-BORNE ENCEPHALITIS VIRUS;

EID: 42649113388     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.01.010     Document Type: Article

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